Can brief interventions delivered in schools reduce substance use among adolescents?
Can cannabinoid type 1 receptor antagonists help smokers to quit, and could they also reduce the amount of weight gained during the quitting process?
Can changing antipsychotic medication improve side effects like increases in weight, blood sugar and cholesterol?
Can cognitive behavioural therapy reduce harmful sexual behaviour in adolescents?
Can cognitive stimulation benefit people with dementia?
Can community interventions deter young people from starting to smoke?
Can community interventions reduce smoking among adults
Can community pharmacy interventions help improve pharmacy workers' skills and pharmacy users' health outcomes through health promotion?
Can cytokines and growth factors help prevent mouth soreness and ulcers (oral mucositis) in patients being treated for cancer?
Can day care programs for children under 6 years of age in low- to middle-income countries reduce their risk of drowning?
Can dental professionals help people to stop smoking or using tobacco products?
Can dihydrocodeine reduce illegal opiate use in adolescents and adults?
Can dopamine agonists prevent ovarian hyperstimulation syndrome in women undergoing fertility treatment with IVF or ICSI?
Can electronic cigarettes help people stop smoking, and do they have any unwanted effects when used for this purpose?
Can ethical case interventions improve healthcare?
Can exenatide, a diabetes drug, be used to treat Parkinson's disease?
Can exercise give better results after spinal surgery for spinal stenosis?
Can exercise help people quit smoking?
Can exercise interventions enhance health-related quality of life among cancer survivors?
Can exercise interventions enhance health-related quality of life among people with cancer undergoing active treatment?
Can exercise, for women with gestational diabetes, improve outcomes for mother and her baby?
Can exercising before vaccination reduce numbers of adults who get flu or develop complications?
Can exhaled nitric oxide be used to adjust asthma medications in children with asthma?
Can health care providers who are not doctors perform abortions as well as doctors?
Can illegal cigarette sales to underage youth be prevented, and does it change their smoking behaviour
Can individual caseworker-assigned discharge plans reduce readmissions for acute exacerbations in children with chronic respiratory disease?
Can inserting a cervical stitch prevent early births of single babies?
Can international travel-related control measures contain the spread of the COVID-19 pandemic?
Can Internet-based interventions help people to stop smoking? 
Can interventions for parents and people caring for children reduce children's exposure to tobacco smoke?
Can interventions to improve professional adherence to guidelines prevent device-related infections?
Can keeping the mouth cold during cancer treatment help to prevent mouth soreness and ulcers in children and adults?
Can lobeline help people to quit smoking
Can mass media campaigns (television, radio, newspapers, billboards and booklets) deter young people from starting to smoke?
Can medicines that block interleukin-6 (a protein involved in immune responses) treat COVID-19?
Can medicines that block interleukin-6 (a protein involved in immune responses) treat COVID-19?
Can mefloquine prevent malaria during travel to areas where the disease is widespread?
Can mindfulness help people to stop smoking?
Can mouthwashes or nasal sprays protect healthcare workers and patients from COVID-19 infection?
Can music interventions benefit people with cancer?
Can music interventions replace sedatives for reduction of preoperative anxiety?
Can nicotine receptor partial agonists, including cytisine and varenicline, help people to stop smoking?
Can nicotine replacement therapy (NRT) help people quit smoking?
Can nicotine vaccines help people stop smoking or help stop recent quitters from relapsing?
Can non-medicinal measures prevent or reduce SARS-CoV-2 infections in long term care facilities?
Can non-pharmacological measures prevent or reduce Covid-19 (SARS-CoV-2) infections in long term care facilities?
Can ocular antibiotics treatment prevent eye infection following a corneal abrasion?
Can oral Astragalus (Huang qi) prevent frequent acute respiratory tract infections in children?
Can organisational infrastructures be effective in promoting evidence-based nursing practice?
Can people be helped to stop smoking before they have surgery?
Can people stop smoking by cutting down the amount they smoke first?
Can percussion, diuresis, and inversion therapy improve outcomes for people with lower pole kidney stones following shock wave lithotripsy?
Can physical exercise improve blood flow through the veins?
Can pressure ulcers be prevented by using different support surfaces?
Can programmes delivered by mobile phones help people to stop smoking?
Can programmes delivered in school prevent young people from starting to smoke?
Can programmes on social media help people to improve their health?
Can psychological therapies help people who self-harm?
Can recruitment strategies make smokers more likely to enter programmes to help them quit smoking?
Can rewards help smokers to quit in the long term?
Can services delivered by pharmacists improve patient health?
Can shared decision-making between the patient and the healthcare professional help people with asthma?
Can smartphone apps improve access to asthma self management?
Can smokers be helped to reduce the harm caused by cigarette smoking by smoking fewer cigarettes or using different tobacco products?
Can smoking cessation interventions among adults with pulmonary tuberculosis improve their tuberculosis treatment outcomes?
Can strategies intended to improve how care is organised or delivered to people with overweight or obesity lead to greater weight reduction?
Can taking inhaled corticosteroids when needed for symptoms help people with mild asthma from becoming more unwell?
Can tests to identify the main draining lymph nodes in women with endometrial cancer accurately diagnose if the cancer has spread to the lymph nodes?
Can tests used to identify the main groin lymph node/s in women with vulval cancer accurately predict whether the cancer has spread to the groin/s?
Can the glucose-lowering drugs insulin secretagogues prevent or delay type 2 diabetes mellitus and its associated complications in persons at increased risk of this disease?
Can the public release of performance data in health care influence the behaviour of consumers, healthcare providers, and organisations?
Can the use of standardised packaging for tobacco products reduce the use of tobacco?
Can third-party inspections of whether healthcare organisations are fulfilling mandatory standards improve healthcare outcomes?
Can tobacco control programmes that include a mass media campaign help to reduce levels of smoking among adults?
Can training health professionals to ask people if they smoke increase offers of advice and help patients quit?
Can ultrasound therapy help to heal venous (varicose) leg ulcers and/or improve symptoms?
Can users of waterpipes be helped to quit through smoking cessation interventions?
Can virtual reality training for cataract surgery supplement or replace other training methods for ophthalmology trainees?
Can we help smokers to increase their use of stop-smoking medicines?
Can xylitol used in products like sweets, candy, chewing gum and toothpaste help prevent tooth decay in children and adults?
Canadian C-spine rule and the National Emergency X-Radiography Utilization Study (NEXUS) for detecting clinically important cervical spine injury following blunt trauma
Cancer genetic risk assessment for individuals at risk of familial breast cancer
Cancer patients with fever and suspected infection can be treated with a single 'new-generation' beta-lactam antibiotic
Cannabinoids for epilepsy
Cannabinoids for the treatment of dementia
Cannabinoids for Tourette syndrome
Cannabis and cannabinoids for people with multiple sclerosis
Cannabis and cannabis oil for the treatment of Crohn's disease
Cannabis and cannabis oil for the treatment of ulcerative colitis
Cannabis for schizophrenia
Cannabis products for adults with chronic neuropathic pain
Cannabis products for people with fibromyalgia
Cannabis-based medicine for nausea and vomiting in people treated with chemotherapy for cancer
Cannabis-based medicines and medical cannabis for adults with cancer pain
Cannabis-based medicines for prevention of postoperative nausea and vomiting in adults
Capsaicin applied to the skin for chronic neuropathic pain in adults
Capsaicin for allergic rhinitis
Capsaicin for non-allergic rhinitis
Capsule endoscopy for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis
CAR T-cell therapy for people with diffuse large B-cell lymphoma which returns after treatment or no longer responds to treatment
Carbamazepine and oxcarbazepine for the treatment of behavioural and psychological symptoms of dementia (BPSD)
Carbamazepine does not appear to be effective in reducing cocaine dependence, with high dropout rates and adverse effects
Carbamazepine for chronic neuropathic pain and fibromyalgia in adults
Carbamazepine for schizophrenia
Carbamazepine versus phenobarbitone monotherapy (single drug treatment) for epilepsy
Carbamazepine versus phenytoin (given as a single drug treatment) for epilepsy
Carbamazepine versus valproate monotherapy for epilepsy
Carbetocin for preventing postpartum haemorrhage
Carbohydrate or fat-restricted diets for obesity
Carbohydrate supplementation of human milk to promote growth in preterm infants
Carbon dioxide detection for diagnosis of inadvertent respiratory tract placement of enterogastric tubes in children
Carbon dioxide detection for testing nasogastric tube placement in adults
Carbonic anhydrase inhibitors for hypercapnic ventilatory failure in chronic obstructive pulmonary disease
Cardiac resynchronization therapy for dilated cardiomyopathy
Cardiac testing for coronary artery disease in potential kidney transplant recipients
Cardioselective beta-blockers for reversible airway disease
Cardiotocography (a form of electronic fetal monitoring) for assessing a baby's well-being in the womb during pregnancy
Cardiotocography for antepartum fetal assessment
Cardiovascular safety of phosphodiesterase inhibitors for treating erectile dysfunction in elderly men
Care co-ordination interventions to improve outcomes during pregnancy and early childhood (up to 5 years)
Care delivery and self management strategies for adults with epilepsy
Care delivery and self-management strategies for children with epilepsy
Care for pregnant women who have experienced genital cutting
Care planning or case management for frequent emergency department attendance in adults
Care prior to the next pregnancy for women diagnosed with gestational diabetes
Caregiver-mediated exercises for improving outcomes after stroke
Cariprazine versus placebo for schizophrenia
Carisbamate add-on therapy for drug-resistant focal epilepsy
Carnitine for fatigue in patients with multiple sclerosis (MS)
Carnitine supplementation for preterm infants with recurrent apnoea
Carnitine supplementation of parenterally fed neonates
Carnitine supplements for people with chronic kidney disease requiring dialysis
Carnitine supplements for treating people with inborn errors of metabolism
Carotid endarterectomy for asymptomatic carotid stenosis
Carotid endarterectomy for carotid stenosis in patients selected for coronary artery bypass graft surgery
Carotid surgery in people who have symptoms with narrowing of the carotid artery
Case management approaches to home support for people with dementia
Case management for integrated care of frail older people in community settings
Case management for people with severe mental disorders
Case management: effects on professional practice and health care outcomes
Case mangement for persons with substance use disorders.
Castor oil, bath and/or enema for cervical priming and induction of labour
Cataract surgery in people with age-related macular degeneration
Catherine Marshall appointed Co-Chair of the Governing Board
Catherine Marshall re-appointed Co-Chair of the Governing Board
Catherine Spencer to join Cochrane as new Chief Executive Officer
Catheter ablation for atrial fibrillation
Catheter ablation versus escalation of antiarrhythmic medications for management of ventricular tachycardia in patients with ischaemic heart disease
Catheter ablation versus pharmacological treatment for patients with Wolff-Parkinson-White syndrome
Catheter ablation would be an alternative to inhibit recurrence of paroxysmal or persistent atrial fibrillation
Catheter insertion techniques for improving catheter function and clinical outcomes in peritoneal dialysis patients
Catheter lock treatments for catheter-related infections in children with cancer
Catheter policies for management of long-term voiding problems in adults with nerve damage affecting the bladder
Catheter type, placement and insertion techniques for preventing peritonitis in peritoneal dialysis patients
Catheter-directed therapies for the treatment of massive and submassive acute pulmonary embolism
Cefepime versus other beta-lactam antibiotics for the treatment of infections in non-neutropenic patients
Celebrating 20 years of Cochrane in Spain
Celebrating Anne Anderson and Cochrane diversity with new designs: interview with artist Heather Tubwon
Celebrating the 20th Anniversary of Cochrane Brazil
Celebrating the UN International Day of Older Persons 2021
Celebrating three-years of Cochrane Russia at the Cochrane Russia Symposium
Celecoxib for RA
Celecoxib for Schizophrenia
Celiac plexus block (CPB) in patients with unresectable pancreatic cancer-related pain
Cell salvage (collecting a patient's own blood during surgery) for reducing transfusions with donated blood
Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND)
Cell-based therapy using different sources and different treatment regimens for 'no-option' CLI patients
Celsior solution versus University of Wisconsin solution in liver preservation for transplantation
Cemented versus cementless surgical approach for total hip arthroplasty revision
Cemented versus cementless total hip arthroplasty for osteoarthrosis and other non-traumatic diseases
Cenobamate add-on therapy for drug-resistant focal epilepsy
Central action beta-blockers versus placebo for neuroleptic-induced acute akathisia
Central venous access sites to prevent venous blood clots, blood vessel narrowing, and infection
Central venous catheter coating with antiseptics or antibiotics for reducing catheter-related infections in adults
Central venous catheter removal for adults and children suffering from bloodstream infections caused by Candida species
Centralisation of care may prolong survival in women with ovarian cancer, and possibly more generally, gynaecological cancer
Centre-based day care for children younger than five years of age in high-income countries
Centre-based day care for children younger than five years of age in low- and middle-income countries
Centre-based early education interventions for improving school readiness
Cephalic version by moxibustion for breech presentation
Cephalic version by postural management for breech presentation
CERA treatment for anaemia in people with chronic kidney disease
Ceramic inlays for restoring posterior teeth
Cerebral near-infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults
Cerebral near-infrared spectroscopy monitoring for prevention of brain injury in very preterm infants
Cerebrolysin for acute ischaemic stroke
Cerebrolysin for Alzheimer's disease
Cerebrolysin for vascular dementia
Cerebrospinal fluid drainage for thoracic and thoracic abdominal aortic aneurysm surgery
Cerivastatin for lowering lipids
Cernilton, an extract from rye grass pollen, may help to relieve some urinary symptoms caused by an enlarged prostate gland, but more research is needed.
Certolizumab pegol for maintenance of remission in Crohn’s disease
Certolizumab pegol for the treatment of active Crohn’s disease
Certolizumab pegol for treating adults with rheumatoid arthritis
Cervical assessment by ultrasound for preventing preterm delivery
Cervical cap versus diaphragm for birth control
Cervical ripening before first trimester surgical evacuation for non-viable pregnancy
Cervical stitch (cerclage) for preventing pregnancy loss in women
Cervical stitch (cerclage) in combination with other treatments for preventing premature or early birth of single babies
Cervical stitch for preventing preterm birth in women with a multiple pregnancy
Cervico-thoracic or lumbar sympathectomy for neuropathic pain
Cessation of medication for people with schizophrenia already stable on chlorpromazine
Cetuximab: a new treatment for advanced non-small cell lung cancer
CFTR correctors, a therapy for cystic fibrosis targeted at specific variants (most commonly F508del)
Changes at the workplace for preventing disability in workers on sick leave
Changes in occupational health and safety service arrangements for increasing the uptake of preventive services in small companies
Changes in out-of-pocket payments on utilisation of health care services
Changing atrial fibrillation to a regular heart rhythm using specific drugs has no advantage over controlling the heart rate in elderly people
Changing the length of time a worker is allowed to take time off work because of illness without a physician's certificate
Characteristics of randomised trials in ophthalmology using a single eye per person design
Checklists and specialist teams to recognise and manage sick people in hospital
Checkpoint inhibitors for stage I to III non-small cell lung cancer treated with surgery or radiotherapy with curative intent: a generic protocol
Chelation for autism spectrum disorder (ASD)
Chelation therapy for atherosclerotic cardiovascular (heart and circulation) disease
Chemicals for sticking the outer lung surface to surrounding membranes compared to surgery to stop air persistently collecting in the chest
Chemo-mechanical treatment of tooth decay
Chemo-radiotherapy versus surgery-based treatment for Stage IIIA non-small cell lung cancer: a systematic review and network meta-analysis
Chemoimmunotherapy versus chemotherapy for metastatic malignant melanoma
Chemoprevention agents for prostate cancer
Chemoradiation in locally advanced vulval cancer
Chemoradiotherapy for cervical cancer:  results of a meta-analysis
Chemotherapy (anticancer drugs) for patients with advanced small cell lung cancer
Chemotherapy (drug treatment) for inoperable thymic cancer in adults
Chemotherapy after surgery for early stage non-small cell lung cancer
Chemotherapy after surgery for stage III and IV endometrial cancer
Chemotherapy after surgery versus surgery alone for stomach cancer
Chemotherapy alone versus endocrine therapy alone for metastatic breast cancer
Chemotherapy and radiotherapy may improve survival and quality of life in people with advanced pancreatic cancer
Chemotherapy and supportive care versus supportive care alone for advanced non-small cell lung cancer
Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma
Chemotherapy before surgery for patients with surgically removable cancer of the esophagus
Chemotherapy before surgery in patients with adenocarcinoma of the esophagus, the gastroesophageal junction, and the stomach
Chemotherapy before surgery or radiotherapy or both for women with cervical cancer that has spread beyond the cervix to the tissues close by
Chemotherapy can improve survival rates for non-small cell lung cancer
Chemotherapy delivered via the hepatic artery following surgical resection of liver metastases arising from colorectal cancer does not improve survival.
Chemotherapy for adult women diagnosed with a rare type of ovarian cancer of all stages (malignant germ cell cancer of the ovary)
Chemotherapy for advanced gastric cancer
Chemotherapy for children with medulloblastoma
Chemotherapy for downsizing unresectable liver metastases from colorectal cancer
Chemotherapy for gallbladder cancer
Chemotherapy for men with prostate cancer who have not responded to hormone therapy
Chemotherapy for mouth and throat cancer
Chemotherapy for newly diagnosed inoperable brain metastases from non-small cell lung cancer
Chemotherapy for relapsed epithelial ovarian cancer
Chemotherapy for treating high-grade osteosarcoma in children and young adults
Chemotherapy given before surgery, compared with surgery alone for women with cervical cancer
Chemotherapy improves the survival of people with advanced colorectal cancer, but the adverse effects and impact on quality of life are not yet known.
Chemotherapy of second-stage Human African trypanosomiasis
Chemotherapy primarily aimed at improving length of life while maintaining quality of life for incurable cervical cancer
Chemotherapy versus surgery with or without adjuvant chemotherapy and radiotherapy for localised primary gastric diffuse large B-cell lymphoma