We assessed evidence for the benefits and harms of oral Astragalus used alone to prevent frequent episodes of acute respiratory infections (ARTIs) in children aged up to 14 years, compared to a dummy treatment. ARTIs include colds, sore throats, laryngitis, influenza, bronchitis and pneumonia.
Many therapies are used to prevent ARTIs, especially in children. Astragalus, is a widely used and available herbal therapy that has been used for thousands of years in China to help prevent ARTIs. It is thought to boost immunity. Almost one in five children experience frequent ARTIs and treatment accounts for up to 75% of all prescribed antibiotics for children. Because most ARTIs are caused by viruses, antibiotics are not effective in treating these illnesses.
We searched the literature up to 31 December 2015.
We identified 6080 potentially relevant records. After removing duplicate records, and those that did not meet our inclusion criteria, we obtained 120 full-text studies. We carefully assessed these studies for possible inclusion. We excluded most studies because: they presented unclear diagnosis criteria; Astragalus preparation was used with other agents; or Astragalus was not compared with a dummy treatment. No studies met our inclusion criteria and so we were unable to analyse any results.
Study funding sources
We could not assess study funding sources.
We did not find any studies that compared use of oral Astragalus alone with a dummy treatment to prevent frequent episodes of ARTI in children aged up to 14 years. Well-designed, conducted and reported studies investigating this issue are needed to enable assessment in the future.
Quality of the evidence
We could not assess evidence quality.
We found insufficient evidence to enable assessment of the effectiveness and safety of oral Astragalus as a sole intervention to prevent frequent ARTIs in children aged up to 14 years.
Acute respiratory tract infections (ARTIs) are common in children and can involve both upper and lower airways. Many children experience frequent ARTI episodes or recurrent respiratory tract infections (RRTIs) in early life, which creates challenges for paediatricians, primary care physicians, parents and carers of children.
In China, Astragalus (Huang qi), alone or in combination with other herbs, is used by Traditional Chinese Medicine (TCM) practitioners in the form of a water extract, to reduce the risk of ARTIs; it is believed to stimulate the immune system. Better understanding of the therapeutic mechanisms of Astragalus may provide insights into ARTI prevention, and consequently reduced antibiotic use.
To assess the effectiveness and safety of oral Astragalus for preventing frequent episodes of acute respiratory tract infections (ARTIs) in children in community settings.
We searched the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 12, 2015), MEDLINE (Ovid) (1946 to 31 December 2015), Embase (Elsevier) (1974 to 31 December 2015), AMED (Ovid) (1985 to 31 December 2015), Chinese National Knowledge Infrastructure (CNKI) (1979 to 31 December 2015) and Chinese Scientific Journals full text database (CQVIP) (1989 to 31 December 2015), China Biology Medicine disc (CBM 1976 to 31 December 2015) and Wanfang Data Knowledge Service Platform (WanFang) (1998 to 31 December 2015).
We included randomised controlled trials (RCTs) comparing oral Astragalus as a sole Chinese herbal preparation with placebo to prevent frequent episodes of ARTIs in children.
We used standard Cochrane methodological procedures for this review. We assessed search results to identify relevant studies. We planned to extract data using standardised forms. Disagreements were to be resolved through discussion. Risk of bias was to be assessed using the Cochrane 'Risk of bias' tool. We planned to use mean difference (MD) or standardised mean difference (SMD) for continuous data and risk ratio (RR) or odds ratio (OR) to analyse dichotomous data, both with 95% confidence intervals (CIs).
We identified 6080 records: 3352 from English language databases, 2724 from Chinese databases, and four from other sources. Following initial screening and deduplication, we obtained 120 full-text papers for assessment. Of these, 21 were not RCTs; 55 did not meet the inclusion criteria because: participants were aged over 14 years; definition was not included for recurrent or frequent episodes; Astragalus preparation was not an intervention; Astragalus preparation was in the formula but was not the sole agent; the Astragalus preparation was not administered orally; or Astragalus was used for treatment rather than prevention of ARTI. A further 44 studies were excluded because they were not placebo-controlled, although other inclusion criteria were fulfilled.
No RCTs met our inclusion criteria.