| Antiplatelet therapy for preventing stroke and other vascular events after carotid endarterectomy |
| Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks |
| Antiplatelet therapy for preventing stroke in people with atrial fibrillation |
| Antiplatelet versus anticoagulation treatment for patients with heart failure in sinus rhythm |
| Antiproteases for acute pancreatitis |
| Antipsychotic drugs for anorexia nervosa |
| Antipsychotic drugs for elderly people with late-onset schizophrenia |
| Antipsychotic drugs for non-affective psychosis during pregnancy and postpartum |
| Antipsychotic medication for challenging behaviour in people with learning disability |
| Antipsychotic medication for childhood-onset schizophrenia |
| Antipsychotic medication for early episode schizophrenia |
| Antipsychotic medication for elderly people with schizophrenia |
| Antipsychotic medication versus placebo for people with both schizophrenia and learning disability |
| Antipsychotic medications for cocaine dependence |
| Antipsychotic-reduction and/or cessation and antipsychotics as specific treatments for tardive dyskinesia |
| Antipsychotics for antipsychotic-naïve people with psychosis |
| Antipsychotics for fibromyalgia symptoms in adults |
| Antipsychotics for people with epilepsy and psychosis |
| Antipsychotics for people with persistent negative symptoms of schizophrenia |
| Antipsychotics for the treatment of neuropathic pain in adults |
| Antipsychotics to treat delirium in hospitalised patients, not including those in intensive care units |
| Antipyretic measures for treating fever in malaria |
| Antiresorptive agents for the prevention of fractures after spinal cord injury |
| Antiretroviral post-exposure prophylaxis (PEP) for occupational HIV exposure |
| Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals |
| Antiretroviral regimens for patients with HIV who fail first-line antiretroviral therapy |
| Antiretroviral resistance testing in people living with HIV |
| Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples |
| Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection |
| Antiseptic prevents deaths in newborns |
| Antiseptic treatment (chlorhexidine) to prevent tooth decay in children and young people |
| Antiseptics and disinfectants for the treatment of vaginal discharge in non-pregnant women |
| Antiseptics for Burns |
| Antispasmodics for labour |
| Antistaphylococcal immunoglobulins to prevent staphylococcal infection in very low birth weight infants |
| Antithrombin for respiratory distress syndrome in preterm infants |
| Antithrombin III for critically ill patients |
| Antithrombotic drugs for carotid artery dissection |
| Antithrombotic drugs to prevent further blood vessel blockage after bypass surgery using vein grafts obtained from the same person (autologous) or artificial grafts in the legs |
| Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction |
| Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia |
| Antithrombotic treatment following coronary artery bypass surgery: a network meta-analysis |
| Antithrombotics after infra-inguinal bypass grafting |
| Antithrombotics after infra-inguinal peripheral endovascular treatment |
| Antithyroid drug regimen for treating Graves' hyperthyroidism |
| Antitumour antibiotic containing regimens for metastatic breast cancer |
| Antivenom for snake venom-induced neuromuscular paralysis |
| Antiviral agents for hepatitis B virus-related cirrhosis |
| Antiviral agents for treating CMV infection of the nervous system in people with HIV |
| Antiviral agents for treatment of herpes simplex virus infection in neonates |
| Antiviral drugs amantadine and rimantadine for preventing and treating the symptoms of influenza A in adults |
| Antiviral drugs can prevent cytomegalovirus (CMV) infection and disease after an organ transplant. |
| Antiviral drugs for prevention of hepatitis B virus mother-to-child transmission in pregnant women living with both human immunodeficiency virus and hepatitis B virus |
| Antiviral drugs for sudden hearing loss (without known cause) |
| Antiviral drugs used as protective and preventive therapy reduce CMV disease and CMV-associated deaths in solid organ transplant recipients |
| Antiviral medication for the treatment of infectious mononucleosis (glandular fever) |
| Antiviral medicines, interferon, and corneal surface removal in the treatment of herpes simplex virus infection of the eye |
| Antiviral prophylaxis for varicella zoster in immunocompromised patients (excluding haematological malignancies) |
| Antiviral therapy for congenital cytomegalovirus infection in neonates and infants up to 12 months of age |
| Antiviral therapy for genital herpes for prevention of HIV transmission |
| Antiviral therapy for recurrent liver graft infection with hepatitis C virus |
| Antiviral therapy to prevent the recurrence of chronic hepatitis C infection in patients undergoing liver transplantation |
| Antiviral treatment for Bell's palsy |
| Antiviral treatment for chronic hepatitis C in patients with HIV infection |
| Antiviral treatment for influenza infection in people with cystic fibrosis |
| Antiviral treatment for preventing nerve pain after shingles (postherpetic neuralgia) |
| Antiviral treatment for the prevention of mother to child transmission of hepatitis B virus infection |
| Antiviral treatments for lamivudine-resistant chronic hepatitis B adult patients |
| Antivirals for recurrent respiratory papillomatosis |
| Antivirals may provide limited help for the common cold but they are not a cure and none are licensed |
| Apomorphine for the treatment of erectile dysfunction |
| Appendectomy versus antibiotic treatment for acute appendicitis |
| Appendectomy versus antibiotic treatment for acute appendicitis |
| Appetite stimulants for people with cystic fibrosis |
| Apply for the Cochrane-REWARD prize for reducing waste in research |
| Applying negative pressure rapidly or in steps for vacuum extraction assisted vaginal delivery |
| Applying positive pressure at the end of each breath during anaesthesia for prevention of mortality and postoperative pulmonary complications |
| Appointment of a new Editor in Chief for the Cochrane Library |
| Appointment of lead to independent advisory group |
| Appointment of new Interim Chief Executive Officer for Cochrane |
| Approaches for helping children and adolescents with cystic fibrosis to take part in decisions about their healthcare |
| Approaches to guiding oxygen therapy in adult intensive care patients with acute respiratory distress syndrome |
| Approaches to help people with COPD who have one or more long-term conditions |
| Aptrotinin and tranexamic acid may show promise in decreasing blood loss and blood transfusion requirements |
| Aquablation for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia |
| Aquatic exercise for people with osteoarthritis in the knee or hip |
| Aquatic exercise training for fibromyalgia |
| Aquatic therapy exercise for treating rheumatoid arthritis |
| Aqueous shunt surgery and mitomycin C |
| Aqueous shunts for glaucoma |
| Arbidol for preventing and treating influenza in adults and children |
| Are angiotensin receptor blockers (ARBs) an effective treatment for heart failure? |
| Are anti-blood clotting drugs beneficial for people with chronic kidney disease? |
| Are anti-seizure medications effective and safe treatments for Lennox-Gastaut syndrome? |
| Are antibiotics a safe and effective additional treatment for asthma exacerbations? |
| Are antibiotics an effective treatment for COVID-19 and do they cause unwanted effects? |
| Are antibiotics an effective treatment for COVID‐19 and do they cause unwanted effects? |
| Are antibiotics an effective way to prevent infection following tooth removal? |
| Are antibiotics beneficial for flare-ups of chronic obstructive pulmonary disease? |
| Are antibiotics more effective when given continuously or intermittently to people with bronchiectasis? |
| Are antibodies from people who have recovered from respiratory syncytial virus an effective treatment for very young children with respiratory syncytial virus? |
| Are antiplatelets an effective treatment for people with COVID-19? |
| Are antipsychotic medicines safe and effective for treating people who have schizophrenia spectrum disorders with catatonic symptoms? |
| Are any effective treatment options available for the management of granulosa cell tumour of the ovary? |
| Are asthma self-management interventions effective when delivered in schools for children, and how should they be delivered? |
| Are braces effective for treating crossbite (top back teeth biting down inside the bottom back teeth)? |
| Are cardioselective beta-blockers a safe and effective treatment in patients with chronic obstructive pulmonary disease? |
| Are changes to diet effective to manage mineral and bone abnormalities in people with chronic kidney disease? |
| Are circumcision devices safer or faster when compared to standard surgical circumcisions for males older than 10 years? |
| Are combined aclidinium and long-acting beta2-agonist inhalers effective and safe for people with stable COPD? |
| Are communication interventions effective for minimally verbal children with autism spectrum disorder? |
| Are concentrated antibodies from people who have recovered from COVID-19 or animals an effective treatment for people with COVID-19? |
| Are corticosteroids (anti-inflammatory medicines) given orally or by injection an effective treatment for people with COVID-19? |
| Are corticosteroids given orally or by injection an effective treatment for people with COVID-19? |
| Are cyclical progestogens an effective and safe treatment for heavy menstrual bleeding compared to other medical treatments? |
| Are digital contact tracing technologies effective during infectious disease outbreaks? |
| Are direct oral anticoagulants (a type of 'blood thinner') better than conventional anticoagulation for treating people with a blood clot in a deep vein? |
| Are direct oral anticoagulants (a type of 'blood thinner') better than traditional anticoagulants for treating a pulmonary embolism (a blood clot in the lung)? |
| Are diuretics effective for treating people with nephrotic oedema? |
| Are exercises for strengthening breathing muscles effective for people with chronic obstructive pulmonary disease? |
| Are higher or lower salt (sodium) supplements better for premature babies to prevent illness and improve growth and development? |
| Are hypoxia-inducible factor stabilisers effective for management of anaemia among people with chronic kidney disease? |
| Are inflatable sleeves and medication effective to prevent deep vein thrombosis and pulmonary embolism after surgery? |
| Are inhaled anticholinergics added to β2-agonists beneficial in children hospitalised with acute asthma? |
| Are inhaled corticosteroids an effective treatment for people with mild COVID-19? |
| Are inhalers containing umeclidinium bromide effective and safe for people with COPD? |
| Are interventions for fatigue effective among people with kidney failure requiring dialysis? |
| Are interventions for fatigue effective among people with kidney failure requiring dialysis? |
| Are interventions that are implemented in alcohol server settings (e.g. bars and pubs) effective for preventing injuries? |
| Are interventions to improve clinical incidence reporting effective? |
| Are interventions to keep people sleeping on their side the best way to treat obstructive sleep apnoea? |
| Are laboratory-made COVID-19-specific monoclonal antibodies effective to prevent COVID-19 in adults? |
| Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19? |
| Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19? |
| Are local anaesthetics effective for pain management for first trimester surgical abortion? |
| Are local opinion leaders effective in promoting best practice of healthcare professionals and improving patient outcomes? |
| Are medical methods for early termination of pregnancy effective and do they cause unwanted effects? |
| Are medicines that aim to reduce blood loss during surgery effective in surgeries for trauma of the pelvis, hip, or long bones and do they cause unwanted effects? |
| Are medicines that block interleukin-1 effective treatments for COVID-19 and do they cause unwanted effects? |
| Are medicines that block interleukin‐1 (a protein involved in immune responses) effective treatments for COVID‐19 and do they cause unwanted effects? |
| Are medicines that block interleukin‐6 (a protein involved when the body’s immune system overreacts) effective treatments for COVID‐19 and do they cause unwanted effects? |
| Are medicines that delay the start of labour (tocolytics) effective for delaying preterm birth? |
| Are midwife continuity of care models versus other models of care for childbearing women better for women and their babies? |
| Are mixed-speciality (multidisciplinary) teams the best way to help older people recover from hip fracture? |
| Are mobile health technologies useful for improving walking distance in people with intermittent claudication? |
| Are newer methods for destroying the lining of the uterus (endometrial ablation) more effective and safer compared to established methods? |
| Are non-absorbable disaccharides associated with beneficial or harmful effects in people with cirrhosis and hepatic encephalopathy? |
| Are non-steroidal anti-inflammatory drugs safe and effective for treating heavy menstrual bleeding? |
| Are non-steroidal anti-inflammatory medicines known as leukotriene receptor antagonists helpful and safe for eczema? |
| Are opioids the best choice for managing pain in babies after surgery? |
| Are oral antibiotics as effective as a combination of injected and oral antibiotics for kidney infections in children? |
| Are oral blood thinners safe and effective for people being treated for cancer? |
| Are particular types of colloid solution safer for replacing blood fluids than others? |
| Are patient outcomes superior after endovascular or open surgical repair of thoracoabdominal aortic aneurysms? |
| Are physiotherapy or ergonomic workplace adjustments helpful in participants with work-related arm, neck or shoulder complaints? |
| Are population-based interventions (those aimed at entire communities rather than individuals) helpful in preventing falls and fall-related injuries in older people? |
| Are population-based interventions (those aimed at entire communities rather than individuals) helpful in preventing falls and fall-related injuries in older people? |
| Are potassium treatments effective for reduce the excess of potassium among people with chronic kidney disease? |
| Are progestogen treatments effective in preventing miscarriage? |
| Are psychological therapies effective in reducing depression in older adults living in long-term care? |
| Are psychological therapies effective in treating depression in patients with COPD? |
| Are psychological therapies effective in treating depression that did not get better with previous treatment? |
| Are psychosocial interventions effective for treating depression among people on dialysis? |
| Are rotavirus vaccines safe and effective in preventing rotavirus diarrhoea in infants and children? |
| Are school-based programmes aimed at children who are considered at risk of aggressive behaviour, effective in reducing violence? |
| Are shorter courses of systemic steroids as effective as conventional longer courses in the treatment of patients with flare-ups of COPD? |
| Are smoking cessation interventions effective for quitting smoking and reducing disease activity in people with chronic inflammatory joint disease? |
| Are stage-based interventions more effective than non-stage-based ones in helping smokers to quit? |
| Are systemic Janus kinase inhibitors an effective treatment for people with COVID-19? |
| Are telephone or internet check-ups a safe alternative to being seen face-to-face? |
| Are there any differences in survival between people with low-grade glioma having early compared with delayed radiotherapy at the time of progression? |
| Are there any drugs which help reduce bleeding after surgery on blood vessels? |
| Are there any effective interventions to help individuals with depression to quit smoking? |
| Are there any effective interventions to help individuals with schizophrenia to quit or to reduce smoking? |
| Are there any smoking cessation programmes that can help adolescents to stop smoking? |
| Are there effective medications for treating depression that does not improve with the first medication used? |
| Are there effective methods to improve the process of referring patients to specialised care? |
| Are there good ways to find out if people living with HIV are taking their medicines every day? |
| Are there ways in which workplace bullying can be prevented? |
| Are there ways to improve stop-smoking treatment in primary care to help more people to quit smoking? |
| Are tiotropium plus combination inhalers better than tiotropium or combination inhalers alone for the treatment of COPD? |
| Are topical and device-based treatments effective in people with fungal infections of the toenails? |
| Area-wide traffic calming (such as introducing road/speed humps) may reduce death and injury from road traffic crashes but more research is needed |
| Aripiprazole alone or in combination with other drugs for treating the acute mania phase of bipolar disorder |
| Aripiprazole dose for schizophrenia |
| Aripiprazole for autism spectrum disorders (ASD) |
| Aripiprazole for neuroleptic induced hyperprolactinaemia |
| Aripiprazole for people with schizophrenia whose illness has been partially responsive to clozapine |
| Aripiprazole for schizophrenia |
| Aripiprazole versus brexpiprazole for people with schizophrenia |
| Aripiprazole versus chlorpromazine for people with schizophrenia and schizophrenia-like psychoses |
| Aripiprazole versus haloperidol for people with schizophrenia and schizophrenia-like psychoses |
| Aripiprazole versus other atypical antipsychotics |
| Aripiprazole versus perphenazine for people with schizophrenia and schizophrenia-like psychoses |
| Aripiprazole versus placebo for schizophrenia |
| Aripiprazole versus sulpiride for people with schizophrenia and schizophrenia-like psychoses |
| Aripiprazole versus typical antipsychotic drugs for schizophrenia |
| Aripiprazole versus ziprasidone for schizophrenia |
| Arm basis training and arm ability training: two impairment-oriented exercise training techniques for improving arm function after stroke |
| Arm exercise training for COPD |
| Aromatase inhibitors for infertility treatment in women with polycystic ovary syndrome |
| Aromatase inhibitors for infertility treatment in women with polycystic ovary syndrome |
| Aromatase inhibitors for ovulation induction |
| Aromatase inhibitors for short stature in male children and adolescents |
| Aromatase Inhibitors for the adjuvant treatment of breast cancer in postmenopausal women |
| Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women |
| Aromatase inhibitors for women with uterine fibroids |
| Aromatherapy and massage for symptom relief in people with cancer |
| Aromatherapy and massage to relieve symptoms in patients with cancer |
| Aromatherapy for dementia |
| Aromatherapy for pain management in labour |
| Aromatherapy for treating postoperative nausea and vomiting |
| Arsenic trioxide for the treatment of acute promyelocytic leukaemia |
| Art therapy for schizophrenia or schizophrenia-like illnesses |
| Artemether injection for treating people with severe malaria |
| Artemether-lumefantrine (four-dose regimen) for treating uncomplicated malaria |
| Artemether-lumefantrine (six-dose regimen) for treating uncomplicated malaria |
| Artemether-lumefantrine for treating uncomplicated falciparum malaria |
| Artemisinin derivatives for treating severe malaria |
| Artemisinin drugs for treating uncomplicated malaria are better used in combination therapy |
| Artemisinin-based combination therapy (ACT) for treating non-severe malaria due to Plasmodium vivax |
| Artemisinin-based combination therapy for uncomplicated malaria in children with HIV |
| Artemisinin-based combination treatments for uncomplicated malaria |
| Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria |
| Artesunate plus mefloquine in areas with low malaria transmission performed better than mefloquine alone for uncomplicated P. falciparum malaria |
| Artesunate reduces death from severe malaria |
| Arthrocentesis and lavage for treating temporomandibular joint disorders |
| Arthrographic distension for adhesive capsulitis (frozen shoulder) |
| Arthroplasty versus fusion for single-level cervical degenerative disc disease |
| Arthroscopic debridement for osteoarthritis of the knee |
| Arthroscopic surgery for degenerative knee disease |
| Arthroscopy for temporomandibular disorders |
| Artichoke leaf extract for treating high cholesterol levels |
| Artificial corneal devices versus human donor corneas for people undergoing repeat corneal transplantation |
| Artificial intelligence for diagnosing exudative age-related macular degeneration |
| Artificial limb rehabilitation for older people with a leg amputated at or above the knee because of blood circulation problems |
| Artificial opening of the cervix during a planned caesarean section before the start of labour for reducing postoperative problems |
| Artificial tube feeding methods for use with patients with head and neck cancer who are receiving treatment with radiotherapy, chemotherapy or both |
| Artificial, blue-light filtering lenses in the eye for protecting the macula (back of the eye) after cataract surgery |
| As required versus fixed schedule analgesic administration schedules for treating postoperative pain in children and adults |
| Asenapine versus other atypical antipsychotics for schizophrenia |
| Asenapine versus placebo for schizophrenia |
| Asenapine versus typical antipsychotics for schizophrenia |
| Asking men to pass a catheter into their own urethra to try to stop a urethral stricture from coming back |
| Aspiration and sclerotherapy versus hydrocoelectomy for treating hydrocoeles |
| Aspiration of the elbow joint for treating radial head fractures |
| Aspirin (single dose) for relief of perineal pain after childbirth |
| Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia |
| Aspirin and similar drugs for the treatment of deep vein thrombosis (DVT) |
| Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia |
