Are oral antibiotics as effective as a combination of injected and oral antibiotics for kidney infections in children?
Are oral homeopathic medicinal products effective and safe to prevent and treat acute respiratory tract infections in children?
Are particular types of colloid solution safer for replacing blood fluids than others?
Are physiotherapy or ergonomic workplace adjustments helpful in participants with work-related arm, neck or shoulder complaints?
Are psychological therapies effective in treating depression that did not get better with previous treatment?
Are school-based programmes aimed at children who are considered at risk of aggressive behaviour, effective in reducing violence?
Are shorter courses of systemic steroids as effective as conventional longer courses in the treatment of patients with flare-ups of COPD?
Are stage-based interventions more effective than non-stage-based ones in helping smokers to quit?
Are substances that inhibit the growth of new blood vessels (angiogenesis inhibitors), alone or in combination with conventional chemotherapy, likely to improve outcomes for women with ovarian cancer?
Are telephone or internet check-ups a safe alternative to being seen face-to-face?
Are there any differences in survival between people with low grade glioma having early compared with delayed radiotherapy at the time of progression?
Are there any effective interventions to help individuals with depression to quit smoking?
Are there any effective interventions to help individuals with schizophrenia to quit or to reduce smoking?
Are there any smoking cessation programmes that can help adolescents to stop smoking?
Are there effective methods to improve the process of referring patients to specialised care?
Are there ways in which workplace bullying can be prevented?
Are tiotropium plus combination inhalers better than tiotropium or combination inhalers alone for the treatment of COPD?
Area-wide traffic calming (such as introducing road/speed humps) may reduce death and injury from road traffic crashes but more research is needed
Aripiprazole alone or in combination with other drugs for treating the acute mania phase of bipolar disorder
Aripiprazole dose for schizophrenia
Aripiprazole for autism spectrum disorders (ASD)
Aripiprazole for neuroleptic induced hyperprolactinaemia
Aripiprazole for people with schizophrenia whose illness has been partially responsive to clozapine
Aripiprazole for schizophrenia
Aripiprazole versus chlorpromazine for people with schizophrenia and schizophrenia-like psychoses
Aripiprazole versus haloperidol for people with schizophrenia and schizophrenia-like psychoses
Aripiprazole versus other atypical antipsychotics
Aripiprazole versus perphenazine for people with schizophrenia and schizophrenia-like psychoses
Aripiprazole versus placebo for schizophrenia
Aripiprazole versus sulpiride for people with schizophrenia and schizophrenia-like psychoses
Aripiprazole versus typical antipsychotic drugs for schizophrenia
Aripiprazole versus ziprasidone for schizophrenia
Arm basis training and arm ability training: two impairment-oriented exercise training techniques for improving arm function after stroke
Arm exercise training for COPD
Aromatase inhibitors for ovulation induction
Aromatase inhibitors for short stature in male children and adolescents
Aromatase inhibitors for subfertility treatment in women with polycystic ovary syndrome
Aromatase Inhibitors for the adjuvant treatment of breast cancer in postmenopausal women
Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women
Aromatase inhibitors for women with uterine fibroids
Aromatherapy and massage for symptom relief in people with cancer
Aromatherapy and massage to relieve symptoms in patients with cancer
Aromatherapy for pain management in labour
Aromatherapy for promotion of relaxation and sleep, relief of pain, and reduction of depressive symptoms in dementia
Aromatherapy for treating postoperative nausea and vomiting
Arsenic trioxide for the treatment of acute promyelocytic leukaemia
Art therapy for people with dementia
Art therapy for schizophrenia or schizophrenia-like illnesses
Artemether injection for treating people with severe malaria
Artemether-lumefantrine (four-dose regimen) for treating uncomplicated malaria
Artemether-lumefantrine (six-dose regimen) for treating uncomplicated malaria
Artemether-lumefantrine for treating uncomplicated falciparum malaria
Artemisinin derivatives for treating severe malaria
Artemisinin drugs for treating uncomplicated malaria are better used in combination therapy
Artemisinin-based combination therapy (ACT) for treating non-severe malaria due to Plasmodium vivax
Artemisinin-based combination therapy for uncomplicated malaria in children with HIV
Artemisinin-based combination treatments for uncomplicated malaria
Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria
Artesunate plus mefloquine in areas with low malaria transmission performed better than mefloquine alone for uncomplicated P. falciparum malaria
Artesunate plus pyronaridine for treating uncomplicated Plasmodium falciparum malaria
Artesunate reduces death from severe malaria
Arthrocentesis and lavage for treating temporomandibular joint disorders
Arthrographic distension for adhesive capsulitis (frozen shoulder)
Arthroplasty versus fusion for single-level cervical degenerative disc disease
Arthroscopic debridement for osteoarthritis of the knee
Arthroscopy for temporomandibular disorders
Artichoke leaf extract for treating high cholesterol levels
Artificial corneal devices versus human donor corneas for people undergoing repeat corneal transplantation
Artificial limb rehabilitation for older people with a leg amputated at or above the knee because of blood circulation problems
Artificial opening of the cervix during a planned caesarean section before the start of labour for reducing postoperative problems
Artificial tube feeding methods for use with patients with head and neck cancer who are receiving treatment with radiotherapy, chemotherapy or both
Artificial, blue-light filtering lenses in the eye for protecting the macula (back of the eye) after cataract surgery
As required versus fixed schedule analgesic administration schedules for treating postoperative pain in children and adults
Asenapine versus other atypical antipsychotics for schizophrenia
Asenapine versus placebo for schizophrenia
Asenapine versus typical antipsychotics for schizophrenia
Asking men to pass a catheter into their own urethra to try to stop a urethral stricture from coming back
Aspiration and sclerotherapy versus hydrocoelectomy for treating hydrocoeles
Aspiration of the elbow joint for treating radial head fractures
Aspirin (single dose) for relief of perineal pain after childbirth
Aspirin and anti-inflammatory drugs for the prevention of dementia
Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia
Aspirin as an additional treatment for giant cell arteritis
Aspirin desensitisation therapy for aspirin-intolerant chronic rhinosinusitis
Aspirin dosage for the prevention of graft occlusion in people undergoing coronary surgery
Aspirin for acute episodic tension-type headache in adults
Aspirin for primary prevention of coronary heart disease
Aspirin for women undergoing assisted reproductive technology (ART).
Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss
Aspirin to prevent stroke in people with an irregular and rapid heart beat (atrial fibrillation) without rheumatic heart disease and a history of stroke or transient ischaemic attacks (TIA)
Aspirin with or without an antiemetic for acute migraine headaches in adults
Aspirin, steroid and non-steroidal anti-inflammatory drugs use for treating Alzheimer's disease
Assertive community treatment for people with severe mental disorders
Assessing the effects of solid versus liquid dosage forms of oral medications on adherence and acceptability in children
Assessment and support during early labour for improving birth outcomes
Assessment of changes in memory and everyday function in older people using a structured questionnaire, the IQCODE
Assessment of techniques to ascertain correct placement of a breathing tube in neonates
Assisted hatching of fertilised eggs to improve the chances of pregnancy in assisted conception (IVF and ICSI)
Assisted reproductive technology: an overview of Cochrane Reviews
Assisted standing for Duchenne muscular dystrophy
Assistive technology (electronic aids) for children and young people with low vision
Assistive technology for memory support in dementia
Assistive technology for rheumatoid arthritis
Assistive technology, including orthotic devices, for the management of contractures in adult stroke patients
Asthma education for school staff
Asthma reliever inhalers (beta2-agonists) used for exercise-induced asthma and exercise-induced bronchoconstriction
Asthma self management education with either regular healthcare professional review or written action plans or both in adults
Astragalus (a traditional Chinese medicine) for treating chronic kidney disease
At this time, benzodiazepines cannot be recommended for the treatment of non-alcohol related delirium
Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis
Atherectomy for peripheral arterial disease
Atomoxetine for Attention Deficit Hyperactivity Disorder (ADHD) in children and adolescents
Atomoxetine for schizophrenia
Atovaquone-proguanil appears to be more effective than individual drugs for treating uncomplicated malaria, but there are few data comparing atovaquone-proguanil to other combination therapies
Atraumatic restorative treatment (hand instruments only) compared with conventional treatment for managing tooth decay
Atrial fibrillation surgery for patients undergoing heart surgery
Atrial natriuretic peptide for preventing and treating acute kidney injury
Atropine therapy versus no atropine therapy for the prevention of adverse events in paediatric patients undergoing intubation
Attachment to the jejunum versus stomach for the reconstruction of pancreatic stump following pancreaticoduodenectomy ('Whipple' operation)
Attention-based interventions for the management of pain and distress in young children (3-12 years) with burn injuries
Atypical antipsychotic drugs for disruptive behaviour disorders in children and youths
Atypical antipsychotic medications for adolescents with psychosis
Atypical antipsychotics benefit people with dementia but the risks of adverse events may outweigh the benefits, particularly with long term treatment
Atypical antipsychotics for people with both schizophrenia and depression
Atypical Antipsychotics for Tourette's Syndrome
Audio recordings of consultations with doctors for parents of critically sick babies
Audio recordings or written summaries of key consultations for adults with cancer
Audio-visual presentation of information used in the informed consent process for people considering entering clinical trials
Audit and feedback: effects on professional practice and patient outcomes
Audit filters for improving trauma care
Auditory integration therapy for autism spectrum disorders
Auditory-verbal therapy for promoting spoken language development in children with permanent hearing impairments
Aural toilet (ear cleaning) for chronic suppurative otitis media
Auranofin for the treatment of rheumatoid arthritis
Auricular acupuncture for cocaine dependence
Auricular acupuncture for opiate dependence in substance misuse treatment programmes
Australian guideline developers join forces to advance Living Evidence
Autoinflation for hearing loss associated with otitis media with effusion (glue ear)
Autologous blood and platelet rich plasma injection therapy for lateral elbow pain
Autologous bone marrow-derived and blood-derived biological therapies (including cellular therapies and platelet-rich plasma) for bone healing in adults
Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee
Autologous fat grafting for breast reconstruction
Autologous platelet concentrates for treatment of periodontal defects
Autologous platelet-rich plasma (PRP) for chronic wounds
Autologous platelet-rich plasma for treating surgical wounds
Autologous versus prosthetic arteriovenous fistulae for vascular access
Autolytic debridement for pressure ulcers
Automated monitoring for the early detection of sepsis in patients receiving care in intensive care units
Automated telephone communication systems for preventing disease and managing long-term conditions
Automated training devices for improving walking after stroke
Avatar therapy for schizophrenia or related disorders
Avoidance of bottles during the establishment of breast feeds in preterm infants
Awake language mapping for cerebral glioma surgery
Ayurveda interventions for rheumatoid arthritis
Ayurvedic herbal preparations for hypercholesterolaemia
Ayurvedic medicine for schizophrenia
Ayurvedic treatments for diabetes mellitus:
Azapirones for generalized anxiety disorder (GAD)
Azapirones versus placebo for panic disorder in adults
Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis
Azathioprine and 6-mercaptopurine for the maintenance of surgically-induced remission in Crohn’s disease
Azathioprine as an oral corticosteroid sparing agent for asthma
Azathioprine for treating rheumatoid arthritis
Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease
Azathioprine or 6-mercaptopurine for the treatment of active Crohn's disease
Azithromycin for acute lower respiratory tract infections
Azithromycin for treating uncomplicated typhoid and paratyphoid fever (enteric fever)
Azithromycin for treatment of bronchiolitis obliterans syndrome in adult lung transplant recipients
Azithromycin is not useful as monotherapy for uncomplicated malaria. In combinations with other antimalarials, it may need to be used at high doses, potentially affecting tolerability.
Azithromycin versus penicillin G benzathine for early syphilis
B-type natriuretic peptide-guided treatment for heart failure patients
Bacille Calmette-Guerin (BCG) vaccine for induction of remission in Crohn's disease
Back School for the treatment of chronic low back pain
Back schools for acute and subacute non-specific low-back pain
Back schools for non-specific low-back pain
Baclofen for alcohol use disorder
Baclofen for alcohol withdrawal syndrome
Balance training (proprioceptive training) for rheumatoid arthritis.
Balloon angioplasty versus medical therapy for patients with renal artery obstruction and high blood pressure
Balloon dilation of sinus openings for chronic rhinosinusitis
Balloon versus bougie for dilatation of benign oesophageal strictures
Balneotherapy (or spa therapy) for rheumatoid arthritis
Balneotherapy for chronic venous insufficiency
Balneotherapy or spa-therapy for Osteoarthritis
Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults
Banding ligation versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children
Banding ligation versus no intervention for primary prevention in adults with oesophageal varices
Banding ligation versus sclerotherapy for primary prophylaxis of oesophageal varices in children
Banding ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children
Banked preterm versus banked term human milk to promote growth and development in very low birth weight infants
Barbiturate drugs for people with traumatic brain injury
Bariatric surgery for non-alcoholic steatohepatitis in obese patients
Barrier agents for adhesion prevention after gynaecological surgery
Barriers and facilitators to the implementation of doctor-nurse substitution strategies in primary care: qualitative evidence synthesis
Base administration or fluid bolus for preventing morbidity and mortality in preterm infants with metabolic acidosis
Baseline scores of Mini-Mental State examination (MMSE) for early prediction of developing dementia in people with mild cognitive impairments (MCI)
BBC Radio 4 cites new Cochrane evidence
Beclomethasone at different doses for chronic asthma
Become a Cochrane citizen scientist!
Bed rest during pregnancy for preventing miscarriage
Bed rest for acute low-back pain and sciatica
Bed rest for acute uncomplicated myocardial infarction
Bed rest for treating pressure ulcers (bed sores) among wheelchair users
Bed rest in hospital for suspected impaired fetal growth
Bed rest in singleton pregnancies for preventing preterm birth
Bed rest with and without hospitalisation for women who are pregnant with twins or triplets for improving outcomes
Bed rest with or without hospitalisation for hypertension during pregnancy
Bed sharing versus no bed sharing for healthy term neonates
Bedside examination tests to detect beforehand adults who are likely to be difficult to intubate
Beginning reading interventions for children and adolescents with intellectual disability
Behavioral interventions can reduce unprotected sex among men who have sex with men (MSM).
Behavioral interventions to promote condom use among women living with HIV
Behavioral interventions to reduce HIV incidence and HIV/STI prevalence among female sex workers in low- and middle-income countries
Behavioral interventions to reduce HIV transmission among sex workers and their clients in high-income countries
Behaviour changes for dietary and physical exercise modification in overweight and obese adults
Behavioural and cognitive behavioural training interventions for assisting foster carers in the management of difficult behaviour
Behavioural and cognitive-behavioural therapies for treating aggressive behaviour in people with intellectual disabilities
Behavioural and cognitive-behavioural therapy based self-help versus treatment as usual for depression in adults and adolescents
Behavioural and cognitive-behavioural therapy for obsessive-compulsive disorder (OCD) in children and adolescents
Behavioural interventions for dysmenorrhoea
Behavioural interventions for preventing HIV infection in homeless or unstably-housed adults
Behavioural interventions for reducing weight gain in schizophrenia
Behavioural interventions for the treatment of faecal incontinence in children
Behavioural therapies versus other psychological therapies for depression
Behavioural therapies versus treatment as usual for depression
Behavioural treatment for chronic low-back pain
Beirut - the new home of Global Evidence Synthesis Initiative
Belatacept for kidney transplant recipients
Belimumab for systemic lupus erythematosus
Bendamustine for patients with slow-growing lymphoma
Benefits and harms of ablation for people with non-paroxysmal atrial fibrillation
Benefits and harms of celecoxib for treating people with rheumatoid arthritis
Benefits and harms of celecoxib to treat people with osteoarthritis
Benefits and harms of drug-eluting versus bare-metal stents in people with acute coronary syndrome
Benefits and harms of high- versus low-intensity exercise programs for hip or knee osteoarthritis
Benefits and harms of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
Benefits and harms of planned hospital birth compared with planned home birth for low-risk pregnant women
Benefits and harms of sugammadex versus neostigmine in reversing induced paralysis
Benefits of antihypertensive drugs for mild hypertension are unclear
Benefits of patient-reported measures of health and well-being versus traditional follow-up after treatment of gynaecological cancer
Benperidol for schizophrenia
Benzodiazepines alone or in combination with antipsychotic drugs for acute psychosis
Benzodiazepines and related drugs for insomnia in palliative care
Benzodiazepines and related drugs for older depressed people
Benzodiazepines for alcohol withdrawal
Benzodiazepines for antipsychotic-induced tardive dyskinesia
Benzodiazepines for extreme movement problems (catatonia) in people with schizophrenia and other serious mental illnesses.
Benzodiazepines for generalised anxiety disorder (GAD)
Benzodiazepines for neuroleptic-induced acute akathisia
Benzodiazepines for restless legs syndrome