Currently there is no evidence available from randomised control trials to determine whether Single Incision Laparoscopic Surgery provides any better effect than Conventional Multi-incision Laparoscopic Surgery for appendicectomy.
Currently there is no evidence to support the routine use of corticosteroids alone in the management of idiopathic pulmonary fibrosis.
Currently there is not enough evidence to conclude that psychosocial treatments alone are adequate to treat people with opiate abuse and dependence.
Custom-made foot orthoses for the treatment of foot pain 
Customised versus population-based growth charts as a screening tool for detecting small for gestational age infants in low-risk pregnant women
Cutaneous antisepsis for prevention of intravascular catheter–associated infection in newborn infants
Cutting back on sugar-sweetened beverages: What works?
Cutting down or changing the fat we eat may reduce our risk of heart disease
Cyanoacrylate microbial sealants for skin preparation prior to surgery
Cycle regimens for frozen-thawed embryo transfer
Cycled light in the intensive care unit for preterm and low birth weight infants
Cyclin-dependent kinase (CDK) inhibitors for hormone receptor-positive advanced breast cancer
Cycling infrastructure (changes to the road environment) for reducing cycling injuries in cyclists
Cyclo-oxygenase (COX) inhibitors for preventing labour before full-term pregnancy
Cyclo-oxygenase (COX) inhibitors for threatened miscarriage
Cyclo-oxygenase (COX) inhibitors for treating preterm labour
Cyclobenzaprine drug treatment for myofascial pain in adults
Cyclofenil is a drug that has been studied in the treatment for Raynaud's phenomenon and associated conditions. It is not used for RP and is an anabolic steroid. See also Cochrane review on Stanazol which is also an anabolic steroid.
Cyclophosphamide compared to ifosfamide for the treatment of sarcoma in children and young adults
Cyclophosphamide for interstitial lung disease associated with connective tissue disease
Cyclophosphamide for treating rheumatoid arthritis
Cyclophosphamide versus methylprednisolone for lupus
Cyclosporin (the drug for preventing organ rejection after transplant) as an oral corticosteroid sparing agent in stable asthma
Cyclosporin A was without significant effects on mortality, liver transplantation, or progression of primary biliary cirrhosis, and patients given cyclosporin A experienced more adverse events
Cyclosporine A eye drops for the treatment of dry eye
Cyclosporine A for induction of remission in severe ulcerative colitis
Cyclosporine for maintenance of remission in Crohn's disease
Cyclosporine for treating rheumatoid arthritis
Cyclosporine for treatment of active Crohn's disease
Cyproterone acetate appears to be as effective as other medications for hirsutism in women caused by excessive androgen production by the ovaries
Cysteine, cystine or N-acetylcysteine supplementation in parenterally fed neonates
Cytology for the diagnosis of endometrial cancer in symptomatic women
Cytoreductive nephrectomy in metastatic renal cell carcinoma
Cytoreductive surgery alone or combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases in patients with colorectal cancer
Czech Republic to host Global Evidence Summit 2021
D-dimer for excluding pulmonary embolism in hospital outpatient and accident and emergency populations
D-Dimer tests for the diagnosis of deep venous thrombosis in symptomatic hospital outpatients with a clinical prediction rule
D-mannose for preventing and treating urinary tract infections
D-penicillamine did not reduce the risk of mortality of patients with primary biliary cirrhosis but increased the occurrences of adverse events
D-Penicillamine for preventing retinopathy of prematurity in preterm infants
Daclizumab, an antibody, as possible alternative therapy to interferon beta in people with relapsing remitting multiple sclerosis
Daily intake of 1 gr dietary calcium may have moderate protective effect on development of colorectal adenomatous polyps
Daily iron supplementation for prevention or treatment of iron deficiency anaemia in infants, children, and adolescents
Dan Shen agents for acute ischaemic stroke
Danazol for pelvic pain associated with endometriosis
Danazol for treating subfertility
Danazol for treatment of women with symptoms caused by uterine fibroids
Danazol is an effective treatment for the reduction of heavy menstrual bleeding, but the adverse effects may be unacceptable to women
Dance therapy for schizophrenia
Dance/movement therapy for cancer patients
Danshen (Chinese medicinal herb) preparations for acute myocardial infarction
Dapagliflozin for adults with type 2 diabetes mellitus
Dapsone as an oral corticosteroid sparing agent for asthma
Daratumumab and antineoplastic therapy versus antineoplastic therapy only for people with newly diagnosed multiple myeloma ineligible for transplant
Darbepoetin alfa to treat anaemia in people with chronic kidney disease
David Sackett Prize awarded to Sir Iain Chalmers
Day 5 versus day 3 embryo biopsy for preimplantation genetic testing for monogenic/single gene defects
Day care for pre-school children
Day centres for severe mental illness
Day hospital versus admission for acute psychiatric disorders
Day hospital versus outpatient care for people with schizophrenia
Day three versus day two embryo transfer following in vitro fertilisation or intracytoplasmic sperm injection
Day-surgery versus overnight stay surgery for laparoscopic cholecystectomy
De-escalation of dual antiplatelet therapy for patients with acute coronary syndrome after percutaneous coronary intervention: a network meta-analysis of randomised controlled trials
De-escalation techniques for psychosis-induced aggression or agitation
Deadline extended for expressions of interest to host Global Evidence Summit, 2021
Deadline extended: the 2021 Cochrane-REWARD prize for reducing waste in research
Debridement for surgical wounds
Debridement for venous leg ulcers
Debridement of the nasal and sinus cavities in the postoperative care of patients who have had endoscopic sinus surgery for rhinosinusitis
Debriefing interventions for the prevention of psychological trauma in women following childbirth
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage IB2/II cervical cancer
Decentralised versus centralised governance of health services
Decision aids for people deciding about taking part in clinical trials
Decision aids for the management of menopausal symptoms
Decision aids to help people who are facing health treatment or screening decisions
Decision coaching for people making healthcare decisions
Decompressive surgery for treating nerve damage in leprosy
Decongestants, antihistamines and nasal irrigation for acute sinusitis in children
Decontamination of environmental surfaces in hospitals to reduce hospital acquired infections
Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus
Deep brain stimulation for people with involuntary posturing, or dystonia
Deep neuromuscular blockade in adults undergoing an abdominal laparoscopic procedure
Deep transverse friction massage for the treatment of lateral elbow or lateral knee tendinitis
Deep versus shallow suction of endotracheal tubes in ventilated neonates and young infants
Deferasirox for managing iron overload in people with myelodysplastic syndrome
Deferasirox for managing iron overload in people with thalassaemia
Deferasirox for managing transfusional iron overload in people with sickle cell disease
Defining Cochrane’s success
Definitions and reporting of hypoglycaemia in trials of long-acting insulin analogues in people with type 1 diabetes mellitus
Deflation of gastric band balloon in pregnancy for improving outcomes
Degarelix for newly diagnosed advanced prostate cancer
Dehumidifiers in the home for asthma
Dehydroepiandrosterone (DHEA) for lupus erythematosus
Dehydroepiandrosterone for women in the peri- or postmenopausal phase
Delayed antibiotic prescriptions for respiratory tract infections
Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants
Deliberate hypotension for orthopaedic surgery
Delivering clot-busting therapy before reaching hospital or in hospital to help people who are having heart attacks
Delivering the placenta in the third stage of labour
Delivery of intravenous anti-cancer therapy at home versus in hospital or community settings for adults with cancer
Delivery of nutrition (food) to critically ill adults other than by the person eating and swallowing the food/nutrition
Dementia Awareness Week
Dengzhanhua preparations for acute cerebral infarction
Denosumab for the treatment and prevention of postmenopausal osteoporosis
Dental cavity liners under tooth-colored resin fillings placed into permanent teeth in the back of the mouth
Dental extractions prior to radiotherapy to the jaws for reducing post-radiotherapy dental complications
Dental filling materials for managing carious lesions in the primary dentition
Dental fillings for the treatment of caries in the primary dentition
Dental hygiene in addition to drug treatment for Helicobacter pylori eradication
Dental imaging methods for the detection of early tooth decay
Dental treatments for preventing damage to the jawbones in people with cancer receiving radiotherapy to the head and neck
Depot bromperidol decanoate for schizophrenia
Depot flupenthixol decanoate for schizophrenia or other similar mental illnesses
Depot fluphenazine decanoate and enanthate for schizophrenia
Depot fluspirilene for schizophrenia
Depot haloperidol decanoate for schizophrenia
Depot perphenazine decanoate and enanthate for schizophrenia
Depot pipotiazine palmitate and undecylenate for schizophrenia
Deprescribing of chronic benzodiazepine receptor agonists for insomnia in adults
Depression rating scales for detection of major depression in people with dementia
Desferrioxamine mesylate (desferrioxamine) for managing excess iron levels in the blood of people with thalassaemia who depend on blood transfusions
Design-based methods to influence the completeness of response to self-administered questionnaires
Desipramine for neuropathic pain in adults
Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders
Desmopressin acetate (DDAVP) for preventing and treating bleeding in people with mild or moderate haemophilia A
Desmopressin for bedwetting in children
Desmopressin for treating nocturia in men with lower urinary tract symptoms
Desmopressin use for reducing the need for blood transfusion for people having an operation
Despite their widespread use, the value of antibiotics in exacerbations of chronic obstructive pulmonary disease (COPD) remains controversial
Detecting recurrent colorectal cancer by testing for blood carcino-embryonic antigen (CEA).
Determining the optimal method of securely closing the base of the appendix during keyhole surgery after removal of the inflamed appendix
Detoxification treatments for opiate dependent adolescents
Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia ('prediabetes')
Developmental care for promoting development and preventing morbidity in preterm infants
Device-modified trabeculectomy for glaucoma
Devices and pressure sources for administration of nasal continuous positive airway pressure (NCPAP) in preterm neonates
Devices that drain on to the surface of the eye beneath the surface layer to reduce eye pressure in people with or at risk of glaucoma
Devices to continuously monitor sugar (glucose) levels in the blood in newborns born preterm
Devices with safety features for preventing percutaneous exposure injuries in healthcare staff
Deworming school children in low- and middle-income countries
Dexamethasone and peripheral nerve block
Dexmedetomidine and clonidine for long-term sedation during mechanical ventilation in critically ill patients
Dexmedetomidine for analgesia and sedation in newborn infants receiving mechanical ventilation
Dexmedetomidine for prevention of acute pain after abdominal surgery in adults
Dexmedetomidine for procedural sedation in children
Dextropropoxyphene in a single dose taken on its own and also with paracetamol to treat postoperative pain
Diabetes drugs for preventing stroke and other blood vessel disease in people who have had a previous stroke or transient ischaemic attack
Diabetes management in primary care, outpatient and community settings can be improved by interventions targeting health professionals, and organisational interventions that increase continuity of care
Diabetes self-management education and support delivered by mobile health (m-health) interventions for adults with type 2 diabetes mellitus
Diacerein for osteoarthritis
Diagnosis of SARS-CoV-2 infection and COVID-19: accuracy of signs and symptoms; molecular, antigen, and antibody tests; and routine laboratory markers
Diagnostic accuracy of different scans following a CT scan for assessing whether pancreatic and periampullary cancer is resectable
Diagnostic accuracy of total serum bile acids or individual bile acids for intrahepatic cholestasis of pregnancy in woman claiming pruritus
Diagnostic accuracy of ultrasound screening for fetal structural abnormalities during the first and second trimester of pregnancy in low-risk and unselected populations
Diagnostic instruments for autism spectrum disorder (ASD)
Diagnostic test accuracy of self-administered cognitive assessment questionnaires for dementia
Diagnostic tests for assessing rotator cuff tears in people with shoulder pain for whom surgery is being considered
Diagnostic tests for pregnancy-related deep vein thrombosis
Dialysate sodium levels for chronic haemodialysis
Dialysate temperature reduction for intradialytic hypotension for people with chronic kidney disease requiring haemodialysis
Dialyser reuse for people with end-stage kidney disease requiring haemodialysis
DianaHealth portal to improve clinical appropriateness of recommendations
Diaphragm compared to diaphragm with spermicide for birth control
Diaphragm pacing systems for amyotrophic lateral sclerosis / motor neuron disease
Diaphragm-triggered non-invasive respiratory support for preventing respiratory failure in preterm infants
Diaries for recovery from critical illness
Diazepam for treating tetanus
Diazepam monotherapy for epilepsy
Diclofenac for acute postoperative pain in children
Diclofenac for pain relief in children
Diclofenac with or without an antiemetic for acute migraine headaches in adults
Diet and exercise interventions for preventing excessive weight gain during pregnancy
Diet changes for infant colic
Diet or exercise, or both, for weight reduction in women carrying excess weight after childbirth
Diet, physical activity and behavioural interventions for the treatment of overweight or obese adolescents aged 12 to 17 years
Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years
Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk
Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool children up to the age of 6 years
Dietary advice by dietitians to lower blood cholesterol can be more effective than advice by doctors, but may not be more effective than self-help resources.
Dietary advice during pregnancy to prevent gestational diabetes
Dietary advice for people with schizophrenia
Dietary advice for reducing cardiovascular risk
Dietary advice for the prevention of type 2 diabetes mellitus in adults
Dietary advice for treatment of type 2 diabetes mellitus in adults
Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases
Dietary changes in the treatment of Ménière's disease or syndrome
Dietary exclusions for improving established atopic eczema in adults and children
Dietary fibre to prevent cardiovascular disease
Dietary flavonoid for preventing colorectal neoplasms
Dietary intake in people living beyond cancer
Dietary interventions for lowering cholesterol in dialysis patients
Dietary interventions for maintaining cognitive function in cognitively healthy people in late life
Dietary interventions for maintaining cognitive function in cognitively healthy people in mid life
Dietary interventions for multiple sclerosis-related outcomes
Dietary interventions for preventing complications in idiopathic hypercalciuria
Dietary interventions for prevention of dementia in people with mild cognitive impairment
Dietary interventions for recurrent abdominal pain in children
Dietary interventions for stomach ache with no identifiable cause in children
Dietary marine fatty acids (fish oil) for asthma in adults and children
Dietary modifications for managing familial hypercholesterolaemia
Dietary patterns for adults with chronic kidney disease
Dietary regulation for 'gestational diabetes'
Dietary supplementation for preventing and treating pressure ulcers
Dietary supplements for chronic gout
Dietary supplements for established atopic eczema in adults and children
Dietary supplements for pain during menstruation
Dietary supplements for preventing postnatal depression
Dietary supplements for treating foot ulcers in people with diabetes
Dieting to lose weight may lower blood pressure in overweight people with hypertension, but effects are modest and so dieting may not be effective alone.
Diets for inducing and maintaining remission in inflammatory bowel disease (IBD)
Diets for primary prevention of gallbladder stones in adults
Differences in effectiveness and adverse effects between different types of progestogens combined with ethinyl oestradiol (combined contraceptive pill)
Different anthracycline derivates for reducing cardiotoxicity in cancer patients
Different antibiotic regimens for treating pregnant women with bacteria in their urine and without symptoms of urinary tract infection
Different antibiotics for community-acquired pneumonia in otherwise healthy children younger than 18 years of age in hospital and outpatient settings
Different antibiotics for group A streptococcal pharyngitis
Different combinations of inhaled steroids and long-acting beta-agonists for chronic asthma (fluticasone/salmeterol versus budesonide/formoterol)
Different communication strategies for disclosing a diagnosis of schizophrenia and related disorders
Different communication strategies for disclosing results of diagnostic prenatal testing
Different devices for airway management in obese patients during general anaesthesia
Different dosage schedules for reducing damage to the heart in people with cancer receiving anthracycline chemotherapy
Different doses and durations of oral steroids for asthma attacks
Different doses of platelet transfusion for preventing bleeding in people with low platelet counts due to treatment-induced bone marrow failure
Different dressings used to protect the central venous catheter site with the aim of reducing the chance of developing a catheter-related infection
Different fluid therapy strategies for sepsis and septic shock
Different follow-up strategies for women after breast cancer treatment
Different formats and timing of educational interventions for surgical patients
Different functional treatment strategies for acute lateral ankle ligament injuries in adults
Different gases for insufflation of the abdominal cavity during keyhole abdominal surgery
Different implants used to fix certain types of hip fractures
Different infusion durations for preventing platinum-induced hearing loss in children with cancer
Different insulin regimens for type 2 diabetes mellitus
Different localization techniques during surgery of non-palpable breast lumps
Different magnesium sulphate regimens given to mothers to prevent preterm labour
Different magnesium sulphate regimens given to women at risk of preterm birth to help protect the baby’s brain and improve long-term outcomes
Different methods and settings for glucose monitoring for women with gestational diabetes during pregnancy
Different methods of cystic duct occlusion in patients undergoing laparoscopic cholecystectomy
Different methods of external fixation for treating distal radial fractures in adults
Different methods of manipulation for reducing pulled elbow in young children
Different methods of providing automatic external defibrillators to out-of-hospital cardiac arrests to prevent sudden cardiac death
Different methods of treating fractures of the shaft of the thigh bone in children and adolescents
Different methods of ventilation (controlling pressure vs volume) for people with acute respiratory failure due to lung injury
Different rate-controlling agents for the management of atrial fibrillation with rapid ventricular rate in the emergency department: a network meta-analysis
Different regimens of intravenous sedatives or hypnotics for electroconvulsive therapy (ECT) in adult patients with depression
Different regimens of penicillin antibiotics given to women routinely for preventing infection after caesarean section
Different stent graft types to repair thoracic aortic aneurysms
Different stent grafts for repair of abdominal aortic aneurysms
Different strains of probiotics for preventing morbidity and mortality in preterm infants: a network meta-analysis