Does preconception lifestyle advice help people with infertility to have a baby?
Does prophylactic mesh placement around a stoma prevent the development of future hernia and general patient discomfort?
Does quarantine, alone or in combination with other public health measures, control coronavirus (COVID-19)?
Does quit-smoking support delivered by community pharmacy staff help people to stop smoking?
Does random drug and alcohol testing prevent injuries in workers?
Does reducing the amount of salt in a diet improve asthma symptoms?
Does reduction of dialysate temperature affect blood pressure during haemodialysis?
Does reminding people to have vaccinations increase the number of people who receive vaccinations?
Does repair of torn rotator cuff tendons work?
Does silver acetate help people stop smoking
Does smoking in a way that is unpleasant help smokers to quit
Does special assessment of older people getting surgery improve their recovery after surgery?
Does statin therapy improve survival or reduce risk of heart disease in people on dialysis?
Does stopping smoking improve mental health?
Does subfascial endoscopic perforator surgery (leg-vein surgery) help heal venous leg ulcers?
Does supplementation of human milk with calcium and phosphorus improve growth and development in preterm infants?
Does support and intervention from nurses help people to stop smoking?
Does surgical removal of fibroids improve fertility outcomes?
Does surgical removal of the lower leg (amputation) through the knee offer patients improved surgical recovery and better rehabilitation than amputation above the knee?
Does taking a supplement of myo-inositol work as an effective treatment for women who develop diabetes during pregnancy?
Does taking inhaled steorids either before or after being intubated (having a tube down the throat to help you breathe) prevent the painful swelling that can result?
Does taxation of unprocessed sugar or foods with added sugar reduce their consumption and prevent obesity or other adverse health outcomes?
Does telephone counselling help people stop smoking?
Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?
Does the administration of nalbuphine provide effective and safe postoperative pain treatment in children?
Does the design of replacement lenses used in cataract surgery help to stop clouding of the new lens once inside the eye?
Does the measles, mumps, rubella and varicella (MMRV) vaccine protect children, and does it cause harmful effects?
Does the perioperative administration of tramadol provide effective and safe postoperative analgesia in children?
Does the prescription of low-calorie (hypocaloric) nutrition support improve the recovery of critically-ill adult patients?
Does the speed of injection make a difference in the amount of pain and bruising in people receiving heparin injections?
Does the timing and route of nutritional support have an effect on survival and disability in head-injured patients?
Does the use of antimicrobial mouthwash or nasal spray by people who are not actively suspected of having COVID-19 - or by their healthcare workers - protect their healthcare workers when they undertake 'aerosol-generating procedures' on them?
Does tobacco advertising and promotion make it more likely that adolescents will start to smoke
Does tranexamic acid given before an operation reduce blood loss for women with advanced ovarian cancer?
Does treating obstructive sleep apnoea in children who also have chronic cough improve their cough?
Does treating Streptococcal throat infection help improve psoriasis?
Does treatment for gum disease help people with diabetes control blood sugar levels?
Does use of an electronic health record improve the delivery of stop smoking treatment to patients?
Does using a thin sheet of rubber (rubber dam) to isolate teeth from the rest of the mouth during a dental procedure improve the success of tooth repairs?
Does using medication to block the hormone oxytocin help women who are undergoing embryo transfer for fertility treatment increase their chance of having a baby?
Does using the Xpert MTB/RIF diagnostic test instead of smear microscopy when evaluating people for tuberculosis reduce death and successful treatment completion?
Does weekly dosing of paclitaxel improve survival, compared with tri-weekly dosing of paclitaxel in the initial treatment of ovarian cancer?
Does written information reduce antibiotic use for upper airway infections among people treated in primary care settings?
Domestic violence screening and intervention programmes for adults with dental or facial injury
Domiciliary oxygen for chronic obstructive pulmonary disease
Domiciliary oxygen for interstitial lung disease
Dominican Republic will now have free access to Cochrane Reviews
Donepezil for dementia in people with Down Syndrome
Donepezil for people with dementia due to Alzheimer's disease
Donor organ preservation techniques for kidney transplantation
Donor versus no donor comparison of hematopoietic cell transplantation for adult acute lymphoblastic leukemia in first complete remission
Dopamine agents for hepatic encephalopathy
Dopamine agonist therapy in early Parkinson's disease
Dopamine agonists for idiopathic hyperprolactinaemia and prolactinoma in adults
Dopamine agonists for preventing future miscarriage in women with high prolactin levels and a history of recurrent miscarriage
Dopamine agonists for restless legs syndrome
Dopamine agonists for the treatment of people who misuse cocaine
Dopamine agonists for traumatic brain injury
Dopamine for prevention of morbidity and mortality in term newborn infants with suspected perinatal asphyxia
Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies
Dopamine versus dobutamine for hypotensive preterm infants
Dopamine versus no treatment to prevent renal dysfunction in indomethacin-treated preterm newborn infants
Dopaminergic agents versus control for enhancing stroke recovery and rehabilitation
Dopaminergic antagonists for alcohol dependence
Doppler trans-thoracic echocardiography for detection of pulmonary hypertension in adults
Doppler ultrasound for fetal assessment in high risk pregnancies
Doppler ultrasound of blood vessels in the placenta and uterus of pregnant women as a way of improving outcome for babies and their mothers
Doppler ultrasound of fetal blood vessels in normal pregnancies
Doppler ultrasound of fetal vessels in pregnancies at increased risk of complications
Doppler ultrasound, CT angiography, MR angiography, and contrast-enhanced MR angiography versus intra-arterial angiography for moderate and severe carotid stenosis in symptomatic patients
Dornase alfa, an inhaled drug, for treating lung disease in cystic fibrosis
Dosage intervals of amoxicillin for the treatment of acute middle ear infection
Dose reduction and discontinuation of disease-modifying anti-rheumatic drugs (DMARDs) for juvenile idiopathic arthritis
Dose-escalated radiotherapy for clinically localised and locally advanced prostate cancer
Double gloving to reduce surgical cross-infection
Double versus single intrauterine insemination for subfertile couples
Double wall versus single wall incubator for reducing heat loss in very low birth weight infants in incubators
Double-bundle versus single-bundle reconstruction for anterior cruciate ligament rupture in adults
Double-stapled anastomosis versus mucosectomy and handsewn anastomosis in ileal pouch-anal anastomosis for ulcerative colitis or familial adenomatous polyposis
Doubtful effect of lecithin as a treatment for dementia
Doxapram for the prevention and treatment of apnea in preterm infants
Doxapram for ventilatory failure due to exacerbations of chronic obstructive pulmonary disease
Doxapram treatment for apnea in preterm infants
Doxapram versus methylxanthine for apnea in preterm infants
Doxazosin for benign prostatic obstruction
Doxorubicin after initial treatment for sarcoma reduces risk of recurrence
Doxycycline plus ivermectin for preventing and treating river blindness (onchocerciasis)
Doxycycline for osteoarthritis
Dr Matthew Page on winning the 2018 Bill Silverman Prize
Dr. Christian Osadnik wins Monash University 2018 Faculty Early Career Research prize for Cochrane Review
Dr. David Tovey awarded Emeritus Editor-in-Chief
Drain use after an appendectomy for complicated appendicitis
Drain use after pancreatic surgery
Drainage tube placement after lymph gland removal from the armpit for breast cancer
Drains are often used after thyroid operations.
Drains for leg artery surgery
Drains increase the harms to patients undergoing open cholecystectomy
Drains versus no drains after pelvic lymphadenectomy to prevent lymphocyst formation in women with gynaecological cancer
Drama therapy for schizophrenia or schizophrenia-like illnesses
Dressings and securement devices to prevent complications for peripheral arterial catheters
Dressings and securement for central venous catheters (CVCs)
Dressings and topical agents (creams or lotions) for preventing pressure ulcers
Dressings and topical agents (gels, ointments and creams) for treating venous leg ulcers
Dressings and topical agents containing hyaluronic acid for chronic wound healing
Dressings and topical agents for arterial leg ulcers
Dressings and topical agents for donor sites of split-thickness skin grafts
Dressings and topical agents to help surgical wounds heal by secondary intention
Dressings for healing venous leg ulcers
Dressings for the prevention of surgical site infection
Dressings for treating superficial and partial thickness burns
Dressings that use negative pressure for closed surgical wounds
Dressings to treat foot ulcers in people with diabetes
Drinking extra water or other non-caloric beverages for promoting weight loss or preventing weight gain
Driving assessment for maintaining mobility and safety in drivers with dementia
Driving rehabilitation for stroke
Droperidol for psychosis-induced aggression or agitation
Droperidol for the treatment of nausea and vomiting (sickness) in people with advanced disease
Drug and nutritional treatment for McArdle disease
Drug combinations for chronic neuropathic pain in adults
Drug delivery technique using electrical current for the treatment of non-muscle invasive bladder cancer
Drug interventions for deliberately altering blood pressure in acute stroke
Drug interventions for the treatment of obesity in children and adolescents
Drug interventions versus placebo for the treatment of Raynaud’s phenomenon: generic protocol
Drug management for acute tonic-clonic convulsions (fits), including convulsive status epilepticus in children
Drug or psychological interventions for preventing depression in people with long-term physical conditions
Drug therapy for chronic idiopathic axonal polyneuropathy
Drug therapy for delirium in terminally ill adults
Drug therapy for Mycetoma
Drug therapy for obstructive sleep apnoea in adults
Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease
Drug therapy for treating idiopathic thrombocytopenic purpura during pregnancy
Drug therapy for treating systemic intravascular activation of coagulation in patients with leukemia
Drug therapy to treat high levels of uric acid in people with high blood pressure
Drug treatment for borderline personality disorder
Drug treatment for children with bedwetting (nocturnal enuresis) but not including the drug types desmopressin or tricyclics
Drug treatment for depression in multiple sclerosis
Drug treatment for faecal incontinence in adults
Drug treatment for familial amyloid polyneuropathy
Drug treatment for lower urinary tract symptoms in women with voiding dysfunction
Drug treatment for myotonia (delayed muscle relaxation after contraction) in muscle diseases such as myotonic dystrophy and myotonia congenita
Drug treatment for pain in Guillain-Barré syndrome
Drug treatment for respiratory syncytial virus lung infections
Drug treatment for small abdominal aortic aneurysms
Drug treatment for spinal muscular atrophy type I
Drug treatment of recurrent abdominal pain in children
Drug treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for acute Guillain Barré syndrome
Drug treatments and electronic cigarettes for stopping smoking in pregnancy
Drug treatments for apathy in Alzheimer's disease
Drug treatments for chronic cognitive impairment in traumatic brain injury
Drug treatments for chronic hair-pulling (trichotillomania)
Drug treatments for constipation caused by antipsychotic medications
Drug treatments for dysthymia
Drug treatments for managing cystic fibrosis-related diabetes
Drug treatments for pain in children and young people with life-limiting conditions
Drug treatments for pain relief in hysterosalpingography
Drug treatments for sexual offenders or those at risk of offending
Drug treatments that specifically target ammonia for adults with cirrhosis and hepatic encephalopathy
Drug treatments to ease breathlessness in cystic fibrosis
Drug-based and non-drug-based interventions to improve the bone mineral density in patients living with HIV
Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for stenosis of stents in lower limb arteries
Drug-eluting bead transarterial chemoembolisation for unresectable hepatocellular carcinoma
Drug-eluting stents versus bare metal stents for angina or acute coronary syndromes
Drug-eluting stents versus bare-metal stents for non-acute ischaemic heart disease
Drug-free management of young children's pain during medical procedures
Drugs (with the exception of botulinum toxin) to treat spasticity after stroke
Drugs against parasites for prevention of Chagas heart disease
Drugs and natural products for self-harm in adults
Drugs and natural products for self-harm in adults
Drugs and pacemakers for transient loss of consciousness
Drugs as treatment for self-injurious behaviour in adults with intellectual disabilities
Drugs commonly-used for preventing high altitude illness
Drugs for cancer-related fatigue
Drugs for discoid lupus erythematosus
Drugs for general anaesthesia for caesarean section
Drugs for itching in adult palliative care patients
Drugs for motor complications in people with Parkinson´s disease who are already taking levodopa
Drugs for nocturia in adults
Drugs for perineal pain in the early postpartum period: generic protocol
Drugs for preventing blood clot dissolution (antifibrinolytic therapy) to reduce the occurrence of rebleeding in aneurysmal subarachnoid haemorrhage
Drugs for preventing dry mouth and problems with saliva after radiotherapy
Drugs for preventing graft versus host disease
Drugs for preventing headache after a lumbar puncture
Drugs for preventing hepatitis B recurrence after liver transplantation
Drugs for preventing kidney disease in people with diabetes
Drugs for preventing lung cancer in healthy people
Drugs for preventing major morbidity and mortality related to blood pressure and heart rate changes associated with tracheal intubation
Drugs for preventing migraine headaches in children
Drugs for preventing nausea and vomiting after surgery
Drugs for reducing iron in people with acute stroke
Drugs for reducing stomach acid for people with cystic fibrosis
Drugs for the acute treatment of migraine in children and adolescents
Drugs for the prevention and treatment of pruritus in patients receiving neuraxial opioids
Drugs for the prevention of postoperative urinary retention in adults
Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease)
Drugs for treating giardiasis
Drugs for treating giardiasis
Drugs for treating headache after a lumbar puncture
Drugs for treating people with sleepiness during shift work and sleep problems after shift work
Drugs for treating Schistosoma mansoni infection
Drugs for treating urinary schistosomiasis
Drugs for treatment of urinary retention after surgery in adults
Drugs for treatment of very high blood pressure during pregnancy
Drugs given to pregnant women and their babies to keep them still during fetal surgery and other invasive procedures on the baby
Drugs improving insulin resistance for non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis
Drugs in overactive bladder syndrome
Drugs other than those used for epilepsy for treating trigeminal neuralgia
Drugs targeting PI3K/AKT/mTOR pathway for locally-advanced, metastatic or recurrent endometrial cancer
Drugs that aim to prevent the loss of protein or albumin through urine in people with sickle cell disease
Drugs that aim to reduce the loss of water from red blood cells in people with sickle cell disease
Drugs that aim to relieve clinical symptoms of tuberous sclerosis complex
Drugs that increase alertness (psychostimulants) for excessive daytime sleepiness (hypersomnia) in myotonic dystrophy
Drugs that prevent oral bleeding in people using oral anticoagulants undergoing minor oral surgery or dental extractions
Drugs that prevent oral bleeding in people with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions
Drugs that suppress or modify the immune system for dermatomyositis and polymyositis
Drugs that target abnormal growth protein in high-grade, aggressive brain tumours
Drugs that target blood vessels in malignant brain tumours
Drugs to break down blood clots for people with sudden onset peripheral arterial occlusion
Drugs to control the movement of salt in the lungs of people with cystic fibrosis
Drugs to dissolve pulmonary embolism (blood clot in the lungs)
Drugs to help end amphetamine dependence are not very helpful, and more research is needed.
Drugs to help reduce anxiety in people nearing the end of life due to illness
Drugs to improve blood flow for people who have poor blood circulation in the veins of their legs
Drugs to prevent clots after bleeding in the brain
Drugs to prevent heart damage in cancer patients receiving anthracyclines
Drugs to prevent malaria in HIV-positive pregnant women.
Drugs to prevent nausea and vomiting in children and young people undergoing chemotherapy
Drugs to prevent the re-occurrence of narrowing of blood vessels in peripheral arterial disease after the blood vessels have been surgically widened
Drugs to reduce bleeding and transfusion in adults undergoing cardiac surgery: a systematic review and network meta-analysis
Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-analysis
Drugs to suppress the immune system after lung transplantation in people with cystic fibrosis
Drugs to treat acute respiratory distress syndrome in adults
Drugs to treat fibroids
Drugs to treat phantom limb pain in people with missing limbs
Drugs used as add-on therapy to heart procedure following heart attack
Drugs used to lower blood pressure do not reduce sudden death
Drugs used to treat the symptoms of patellofemoral syndrome have little evidence base
Dual antibiotics for bronchiectasis
Dual task training for improving balance and gait in people with stroke
Duloxetine can improve the quality of life of patients with stress urinary incontinence, long-term effects of the treatment are unclear.
Duloxetine for generalised anxiety disorder (GAD)
Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia
Duloxetine versus other antidepressive agents for depression
Duodenum-preserving pancreatic resection versus pancreaticoduodenectomy for chronic pancreatitis
Duplex ultrasound for surveillance of lower limb revascularisation
Duplex ultrasound for the detection of stenosis after peripheral arterial bypass grafting using autologous vein
Duplex ultrasound for the diagnosis of symptomatic deep vein thrombosis in the lower limb
Duration of 5FU based chemotherapy in adjuvant setting for colorectal cancer should not exceed 6 months.
Duration of antibacterial treatment for uncomplicated urinary tract infection in women
Duration of antibiotic treatment for foot osteomyelitis in people with diabetes