| Do any treatments help people who have successfully quit smoking to avoid starting smoking again? |
| Do automated mandatory boluses of epidural medications provide superior labour pain relief than basal infusion? |
| Do azole medicines taken as a cream or drops work for treating otomycosis (a fungal ear infection)? |
| Do bans on smoking and intensive educational campaigns reduce smoking in public places |
| Do beds, mattresses and mattress toppers that apply constant pressure to the skin and are not air-filled or made of foam prevent pressure ulcers? |
| Do beds, mattresses and mattress toppers with air-filled surfaces that apply constant pressure to the skin prevent pressure ulcers? |
| Do beds, mattresses and mattress toppers with air-filled surfaces that regularly redistribute pressure under the body prevent pressure ulcers? |
| Do blood thinner injections given after abdominal surgery further reduce blood clots if continued after discharge from the hospital? |
| Do blood thinners prevent blood clots in children who are treated using central lines? |
| Do blood thinners prevent people who are hospitalised with COVID-19 from developing blood clots? |
| Do blood thinners prevent people who are hospitalised with COVID‐19 from developing blood clots? |
| Do braces correct or improve 'underbite' (prominent lower front teeth) in children and teens? |
| Do burns patients who receive early (within 24 hours) nutritional support have better outcomes than those whose nutritional support is delayed (after 24 hours)? |
| Do cancer vaccines help people with advanced non-small cell lung cancer? |
| Do combined inhalers (steroid plus bronchodilator) offer additional benefits or harms in people with COPD compared with the bronchodilator alone? |
| Do competitions help smokers to quit in the medium to long term? |
| Do courses aimed at improving the way healthcare professionals communicate with people who have cancer impact on their physical and mental health? |
| Do diet and physical activity strategies help prevent obesity in children (aged 0 to 18 years)? |
| Do different settings and techniques for measuring blood pressure during pregnancy help to improve outcomes for women and babies? |
| Do digital technologies help people with cystic fibrosis stick to their inhaled treatments? |
| Do early intervention programmes improve physical and mental development in babies born too early? |
| Do education and training programs reduce aggressive behavior toward healthcare workers? |
| Do electronic or robotic gait-training devices help people walk better after a stroke? |
| Do epidermal growth factor receptor (EGFR) inhibitors, alone or with chemotherapy, improve outcomes for women with epithelial ovarian cancer (EOC)? |
| Do group-based smoking cessation programmes help people to stop smoking? |
| Do H1 antihistamine tablets or liquids help improve eczema symptoms in people who are already using creams or ointments for their eczema? |
| Do health education interventions lead to early treatment for women with symptoms of endometrial (womb) cancer |
| Do health promotion programmes in the workplace increase people's physical activity if they include a pedometer? |
| Do heated tobacco products help people to quit smoking, are they safe for this purpose, and have they led to falls in smoking rates? |
| Do incentives help keep young people from starting to smoke in the medium to long term? |
| Do inhaled corticosteroids reduce growth in children with persistent asthma? |
| Do inhaled steroids increase the risk of pneumonia in people with chronic obstructive pulmonary disease (COPD)? |
| Do injectable pneumococcal vaccines prevent pneumonia in people with COPD? |
| Do interventions in families prevent children and adolescents from starting to smoke |
| Do interventions that reduce the cost of smoking cessation treatment increase quit rates, quit attempts or use of treatments? |
| Do interventions to enhance one-to-one support provided by partners, family members, or 'buddies' help smokers quit? |
| Do interventions to stop children and adolescents from using electronic cigarettes work? |
| Do invitations, lay health worker interventions and educational interventions increase the uptake of cervical screening? |
| Do local anaesthetic nerve blocks provide effective pain relief for adults with a hip fracture? |
| Do low glycaemic index or low glycaemic load diets help people with overweight or obesity to lose weight? |
| Do magnesium sulfate infusions reduce the need for hospital admission in adults with acute asthma? |
| Do magnesium sulfate infusions reduce the need for hospital admission in children with acute asthma? |
| Do mattresses and mattress toppers made of foam prevent pressure ulcers? |
| Do measures that aim to reduce aerosol production during dental procedures prevent the transmission of infectious diseases? |
| Do media campaigns prevent young people from using illicit drugs? |
| Do medicinal interventions reduce radiation-related bone fractures and risk of avascular necrosis in adults undergoing pelvic radiotherapy? |
| Do medicines for depression help people to quit smoking? |
| Do medicines for weight loss affect blood pressure, and reduce the effects of high blood pressure (hypertension)? |
| Do medicines that restrict new blood vessel growth (angiogenesis inhibitors) help women with epithelial ovarian cancer? |
| Do mobility strategies improve and restore mobility after hip fracture surgery in adults? |
| Do mobility strategies improve and restore mobility after hip fracture surgery in adults? |
| Do nasal decongestants used alone relieve cold symptoms? |
| Do newer laser treatments work better than standard laser treatments for proliferative diabetic retinopathy? |
| Do nonsteroidal anti-inflammatory drugs (NSAIDs) increase the risk of bleeding in children having their tonsils out? |
| Do nutritional interventions reduce gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy? |
| Do opioid antagonists such as naltrexone help people to stop smoking? |
| Do organizational changes to support people quitting smoking improve services and help more people to quit? |
| Do painkillers rubbed on the skin really work? |
| Do PARP inhibitors improve survival in women with ovarian cancer, and what are the side effects? |
| Do patients manage their health care better if they can access their electronic health records? |
| Do people recover from exacerbations of chronic obstructive pulmonary disease (COPD) better in their own home than in the hospital emergency room? |
| Do people with asthma have fewer serious adverse events when taking formoterol and inhaled corticosteroids compared to salmeterol and inhaled corticosteroids? |
| Do people with type 1 diabetes mellitus benefit from using a different type of insulin as their basal insulin? |
| Do pharmacological and non-pharmacological strategies reduce weight in obese women with subfertility? |
| Do pharmacotherapies which reduce anxiety help smokers to quit |
| Do physical activity interventions in outside-school hours care services help increase children's overall daily physical activity? |
| Do physical measures such as hand-washing or wearing masks stop or slow down the spread of respiratory viruses? |
| Do pressure redistributing static chairs help to prevent pressure ulcers? |
| Do printed self-help materials help people to quit smoking? |
| Do probiotics help to treat acute infectious diarrhoea? |
| Do psychological and social interventions prevent mental health disorders in low- and middle-income countries affected by humanitarian crises? |
| Do psychological interventions work for people with both depression and substance use disorders? |
| Do psychological therapies help diabetic foot ulcers to heal and prevent their recurrence? |
| Do psychosocial interventions help parents reduce how often they drink heavily or use drugs? |
| Do psychosocial treatments help people with stimulant use disorder? |
| Do school tobacco policies prevent uptake of smoking? |
| Do school-based physical activity interventions increase moderate to vigorous physical activity and improve physical fitness among children and adolescents? |
| Do school-based physical activity interventions increase moderate to vigorous physical activity and improve physical fitness among children and adolescents? |
| Do services to support the education of children and teenagers with chronic health conditions help to engage them more in school activities and improve learning outcomes? |
| Do short periods of artificially blocking blood flow to the limbs in people undergoing vascular surgery reduce death and organ injury? |
| Do smoking bans at an institutional level help to stop people smoking? |
| Do social support interventions help people with heart disease? |
| Do speed cameras reduce road traffic crashes, injuries and deaths? |
| Do statins prevent kidney failure in adults after surgery where cardiac bypass is used? |
| Do supportive, educational and behavioural interventions improve usage of continuous positive airway pressure in adults with obstructive sleep apnoea? |
| Do synbiotics prevent necrotising enterocolitis in very preterm or very low birth weight infants? |
| Do systemic corticosteroids improve treatment outcomes in flare-ups of chronic obstructive pulmonary disease? |
| Do tobacco cessation interventions provided during substance abuse treatment or recovery help tobacco users to quit? |
| Do treatment effects in randomised trials differ when using active placebo compared to standard placebo? |
| Do upper limb exercise programs work for arteriovenous fistula maturation in people with kidney failure? |
| Do vaginal packing, tranexamic acid, interventional radiology or other interventions control vaginal bleeding in women with advanced cervical cancer? |
| Do ventilators that manage the reduction of ventilator support (weaning) reduce the duration of weaning compared to strategies managed by clinicians? |
| Do video-assisted instruments for inserting breathing tubes in adults work better than direct-view instruments and do they cause unwanted effects? |
| Do video-assisted instruments for inserting breathing tubes in adults work better than direct-view instruments and do they cause unwanted effects? |
| Do weight loss programs have beneficial effects on asthma outcomes in people with asthma? |
| Do weight-loss diets affect blood pressure, and reduce the effects of high blood pressure (hypertension)? |
| Doctors and patients making decisions together could reduce the number of antibiotics prescribed for acute respiratory infections |
| Does 5-ASA prevent the recurrence of diverticulitis? |
| Does a combination of stop smoking medication and behavioural support help smokers to stop? |
| Does a group of drugs known as calcium channel blockers reduce mortality and unfavourable complications in patients with traumatic brain injury? |
| Does a local anaesthetic injection in children and young people having dental treatment under general anaesthetic reduce pain after treatment? |
| Does a tax on the fat content of foods reduce obesity and help people to eat less fat and less saturated fat? |
| Does adding a long-acting muscarinic antagonist (LAMA) to an inhaled steroid help people with uncontrolled asthma more than an inhaled steroid alone? |
| Does adding antileukotriene agents to usual care when people are suffering an asthma attack in the emergency department help? |
| Does adding iron to wheat flour reduce anaemia and increase iron levels in the general population? |
| Does adding rapid diagnostic tests to community-based malaria programmes improve the treatment of people with malaria or fever? |
| Does adding tiotropium, a long-acting muscarinic antagonist (LAMA), to combination therapy (LABA/ICS) help to control asthma? |
| Does administering colony-stimulating factors plus antibiotics in people with fever and low white cell count reduce hospitalization? |
| Does advice from doctors encourage people who smoke to quit |
| Does altering the dose of inhaled corticosteroids make a difference in growth among children with asthma? |
| Does an aminophylline injection in addition to bronchodilators for an asthma attack improve lung function and other outcomes or cause harm? |
| Does banning or restricting advertising for alcohol result in less drinking of alcohol? |
| Does behavioural support help people to stop smoking? |
| Does breastfeeding reduce vaccination pain in babies aged 1 to 12 months? |
| Does chewing gum after a caesarean section lead to quicker recovery of bowel function? |
| Does chromoscopy (dye-spraying) improve rates of polyp detection when compared to conventional colonoscopy? |
| Does cleaning hands with ash stop or reduce the spread of viral and bacterial infections compared with soap or other materials? |
| Does cleaning venous leg ulcers help them to heal? |
| Does clonidine help smokers to quit |
| Does collective leadership improve healthcare professionals' actions, patient health care and staff well-being? |
| Does communicating DNA-based risk estimates motivate people to change their behaviour? |
| Does controlling exposure to house dust mites improve asthma? |
| Does Daikenchuto reduce postoperative ileus in persons undergoing elective abdominal surgery? |
| Does daily sedation interruption reduce the time critically ill adults spend on breathing machines compared to other sedation strategies? |
| Does daily treatment with formoterol result in more serious adverse events compared to placebo or daily salbutamol? |
| Does daily treatment with salmeterol result in more serious adverse events compared with placebo or a salbutamol? |
| Does deep muscle relaxation during laparoscopic surgery improve outcomes? |
| Does delaying cord clamping or using cord milking at birth improve the health of babies born too early? |
| Does delivery of home care by outreach nurses improve outcomes for people with chronic obstructive pulmonary disease? |
| Does denser compared to normal bupivacaine, given as a lower back injection, give more effective and safer anaesthesia during caesarean section |
| Does dermoscopy improve the accuracy of diagnosing basal cell or squamous cell skin cancer (BCC or cSCC) compared to using the naked eye alone? |
| Does dietary fibre prevent the recurrence of colorectal adenomas and carcinomas? |
| Does electromagnetic field stimulation help heal fractures that are failing or have failed to heal? |
| Does encouraging people to wash their hands stop them having diarrhoea? |
| Does enhanced external counterpulsation reduce symptoms of chronic and refractory angina pectoris? |
| Does etidronate prevent fractures caused by osteoporosis in postmenopausal women? |
| Does extended-field radiotherapy reduce death from locally advanced cervical cancer and what are the side effects? |
| Does follow-up with ultrasound after lower limb arterial vascular surgery improve limb salvage rate and maintenance of the open artery? |
| Does giving chemotherapy before surgery improve survival or quality of life for women with advanced ovarian epithelial cancer? |
| Does giving chemotherapy straight away or waiting for symptoms prolong life for persons who have incurable colorectal cancer without symptoms? |
| Does giving chemotherapy, radiotherapy or both improve survival in people with rare (anaplastic oligodendrogliomas and oligoastrocytomas) brain tumours? |
| Does giving daily small, steadily increasing amounts of egg protein help people with egg allergy? |
| Does giving money to people, in low- and middle-income countries, without conditions attached lead to better health and other life improvements? |
| Does giving patients carbohydrate supplements before planned surgery lead to improved recovery? |
| Does giving people feedback on the effects of smoking on their body help them quit smoking? |
| Does group therapy improve well-being in people living with HIV? |
| Does haemodialysis membrane type influence outcomes in people with kidney disease? |
| Does hair removal before surgery prevent infections after surgery? |
| Does heparin locking prevent blocking of central venous catheters in adults when compared to locking with normal saline? |
| Does hormone therapy help transgender women undergoing gender reassignment to transition? |
| Does hormone therapy improve sexual function in women going through or after menopause? |
| Does HPV vaccination prevent the development of cervical cancer? Are there harms associated with being vaccinated? |
| Does hyperbaric oxygen therapy improve outcome after heart attack? |
| Does hyperbaric oxygen therapy improve the survival and quality of life in patients with traumatic brain injury? |
| Does hypnotherapy help people who are trying to stop smoking? |
| Does individually-delivered counselling help people to stop smoking? |
| Does legislation to ban smoking reduce exposure to secondhand smoke and smoking behaviour? |
| Does limiting the times you eat (intermittent fasting) prevent cardiovascular disease? |
| Does mecamylamine help people to stop smoking |
| Does meditation help prevent people from developing cardiovascular disease or from worsening cardiovascular disease? |
| Does meditation help prevent people from developing cardiovascular disease or from worsening cardiovascular disease? |
| Does moisturising baby skin prevent eczema or food allergies? |
| Does monitoring oxygen level with a pulse oximeter during and after surgery improve patient outcomes? |
| Does more support increase success amongst people using medications to quit smoking? |
| Does motivational interviewing help people reduce their use of alcohol, drugs, or both? |
| Does motivational interviewing help people reduce their use of alcohol, drugs, or both? |
| Does motivational interviewing help people to quit smoking? |
| Does Nicobrevin help people to stop smoking |
| Does oestrogen therapy help to treat pelvic organ prolapse in postmenopausal women? |
| Does perioperative blood transfusion affect the recurrence rate of potentially curable operations for colorectal cancer? |
| Does personalised advice via computer or mobile devices reduce heavy drinking? |
| Does physical exercise have beneficial or harmful effects in cirrhosis? |
| Does physiotherapy improve pain and disability in adults with complex regional pain syndrome? |
| Does pioglitazone prevent or delay type 2 diabetes and its complications in people at risk of developing type 2 diabetes mellitus? |
| Does placing a tiny tube (microstent) under the surface of the eye relieve long-lasting high pressure inside the eye (glaucoma)? |
| Does platelet-rich plasmapheresis (PRP) reduce the need for donor blood |
| Does pre-transfusion washing of red blood cells for preterm babies improve their health outcomes? |
| Does preconception lifestyle advice help people with infertility to have a baby? |
| Does prophylactic mesh placement around a stoma prevent the development of future hernia and general patient discomfort? |
| Does quarantine, alone or in combination with other public health measures, control coronavirus (COVID-19)? |
| Does quit-smoking support delivered by community pharmacy staff help people to stop smoking? |
| Does random drug and alcohol testing prevent injuries in workers? |
| Does reducing the amount of salt in a diet improve asthma symptoms? |
| Does reducing your salt intake help to prevent and treat chronic kidney disease in people with diabetes? |
| Does reduction of dialysate temperature affect blood pressure during haemodialysis? |
| Does releasing Wolbachia-carrying mosquitoes prevent dengue infection? |
| Does reminding people to have vaccinations increase the number of people who receive vaccinations? |
| Does repair of torn rotator cuff tendons work? |
| Does routine monitoring of stomach aspirates (partially digested milk and gut hormones withdrawn from the feeding tube) avoid necrotising enterocolitis in premature babies? |
| Does silver acetate help people stop smoking |
| Does smoking in a way that is unpleasant help smokers to quit |
| Does special assessment of older people getting surgery improve their recovery after surgery? |
| Does statin therapy improve survival or reduce risk of heart disease in people on dialysis? |
| Does stopping smoking improve mental health? |
| Does stopping smoking make people with heart disease less likely to have another heart attack? |
| Does subfascial endoscopic perforator surgery (leg-vein surgery) help heal venous leg ulcers? |
| Does supplementation of human milk with calcium and phosphorus improve growth and development in preterm infants? |
| Does support and intervention from nurses help people to stop smoking? |
| Does surgical glue prevent postoperative pancreatic fistula (leaking of fluid from the pancreas) and promote healing after surgery? |
| Does surgical removal of fibroids improve fertility outcomes? |
| Does surgical removal of the lower leg (amputation) through the knee offer patients improved surgical recovery and better rehabilitation than amputation above the knee? |
| Does taking a supplement of myo-inositol work as an effective treatment for women who develop diabetes during pregnancy? |
| Does taking inhaled steorids either before or after being intubated (having a tube down the throat to help you breathe) prevent the painful swelling that can result? |
| Does taxation of unprocessed sugar or foods with added sugar reduce their consumption and prevent obesity or other adverse health outcomes? |
| Does telephone counselling help people stop smoking? |
| Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness? |
| Does testosterone work in men who have problems with erections? |
| Does the administration of nalbuphine provide effective and safe postoperative pain treatment in children? |
| Does the design of replacement lenses used in cataract surgery help to stop clouding of the new lens once inside the eye? |
| Does the measles, mumps, rubella and varicella (MMRV) vaccine protect children, and does it cause harmful effects? |
| Does the number of doses of PEG-asparaginase affect survival and risk of toxicities? |
| Does the perioperative administration of tramadol provide effective and safe postoperative analgesia in children? |
| Does the placement of a breathing tube using video assistance (videolaryngoscopy) increase the success and safety of the procedure in newborn babies? |
| Does the placement of a breathing tube using video assistance (videolaryngoscopy) increase the success and safety of the procedure in newborn babies? |
| Does the prescription of low-calorie (hypocaloric) nutrition support improve the recovery of critically-ill adult patients? |
| Does the separation or grouping, or both of newborn infants in the newborn unit decrease spread of infections? |
| Does the speed of injection make a difference in the amount of pain and bruising in people receiving heparin injections? |
| Does the timing and route of nutritional support have an effect on survival and disability in head-injured patients? |
| Does the type of anaesthesia for recanalisation therapies for acute ischaemic stroke affect patient outcomes? |
| Does the use of antibiotics prevent leptospirosis? |
| Does the use of antimicrobial mouthwash or nasal spray by people who are not actively suspected of having COVID-19 - or by their healthcare workers - protect their healthcare workers when they undertake 'aerosol-generating procedures' on them? |
| Does tobacco advertising and promotion make it more likely that adolescents will start to smoke |
| Does tranexamic acid (a medicine used to improve blood clotting) reduce bleeding during endoscopic surgery for chronic rhinosinusitis? |
| Does tranexamic acid given before an operation reduce blood loss for women with advanced ovarian cancer? |
| Does treating obstructive sleep apnoea in children who also have chronic cough improve their cough? |
| Does treating reduced blood flow to the legs using cells taken from the bone marrow help improve symptoms? |
| Does treating Streptococcal throat infection help improve psoriasis? |
| Does treatment for gum disease help people with diabetes control blood sugar levels? |
| Does use of an electronic health record improve the delivery of stop smoking treatment to patients? |
| Does use of mouth rinse before a dental procedure reduce the risk of infection transmission from patient to health professional? |
| Does using a thin sheet of rubber (rubber dam) to isolate teeth from the rest of the mouth during a dental procedure improve the success of tooth repairs? |
| Does using low-sodium salt substitutes (LSSS) instead of regular salt reduce blood pressure and heart disease risks, and is it safe? |
| Does using medication to block the hormone oxytocin help women who are undergoing embryo transfer for fertility treatment increase their chance of having a baby? |
| Does using the Xpert MTB/RIF diagnostic test instead of smear microscopy when evaluating people for tuberculosis reduce death and successful treatment completion? |
| Does vitamin D reduce risk of severe asthma attacks or improve control of asthma symptoms? |
| Does weekly dosing of paclitaxel improve survival, compared with tri-weekly dosing of paclitaxel in the initial treatment of ovarian cancer? |
| Does written information reduce antibiotic use for upper airway infections among people treated in primary care settings? |
| Domestic violence screening and intervention programmes for adults with dental or facial injury |
| Domiciliary oxygen for chronic obstructive pulmonary disease |
| Domiciliary oxygen for interstitial lung disease |
| Dominican Republic will now have free access to Cochrane Reviews |
| Donate |
| Donepezil for dementia in people with Down Syndrome |
| Donepezil for people with dementia due to Alzheimer's disease |
| Donor organ preservation techniques for kidney transplantation |
| Donor versus no donor comparison of hematopoietic cell transplantation for adult acute lymphoblastic leukemia in first complete remission |
| Dopamine agents for hepatic encephalopathy |
| Dopamine agonist therapy in early Parkinson's disease |
| Dopamine agonists for idiopathic hyperprolactinaemia and prolactinoma in adults |
| Dopamine agonists for preventing future miscarriage in women with high prolactin levels and a history of recurrent miscarriage |
