| Hypomethylating agents for patients with myelodysplastic syndrome |
| Hypothermia (body temperature cooling) for people with an injury to the brain |
| Hysterectomy versus hysterectomy plus ovary removal for premenopausal women |
| Hysterectomy with medical management for cervical cancer that has spread to nearby tissues only |
| Hysteroscopy for treating suspected abnormalities of the cavity of the womb in women having difficulty becoming pregnant |
| Iberogast (STW5) for functional dyspepsia |
| Ibuprofen for pain relief after surgical removal of lower wisdom teeth |
| Ibuprofen for prevention of patent ductus arteriosus in preterm and/or low birth weight infants |
| Ibuprofen for the treatment of patent ductus arteriosus in preterm or low-birth-weight (or both) infants |
| Ibuprofen versus paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth |
| Ibuprofen with or without an antiemetic for acute migraine headaches in adults |
| Ibuprofen-like painkillers given before cutting the skin in surgery compared with given after cutting the skin in adults undergoing all types of surgery |
| Idarubicin for treatment of newly diagnosed acute myeloid leukaemia |
| Ideal length of treatment for Helicobacter pylori (H. pylori) eradication |
| Idebenone for the treatment of Duchenne muscular dystrophy |
| Identification (through screening) of children in the first four years of life for early treatment for otitis media with effusion (OME) |
| Identification of nerves using an electrode compared with visual nerve identification for adults undergoing thyroid surgery |
| Identifying carrier status for thalassaemia, sickle cell disease, cystic fibrosis, or Tay-Sachs disease in non-pregnant women and their partners |
| Identifying the most clinically effective exercise prescription for people with intermittent claudication (MAXIMISE): a component network meta-analysis with concurrent cost-effectiveness analysis |
| Idiotype vaccination for Non-Hodgkin lymphoma |
| Ileostomy or colostomy for temporary decompression of colorectal anastomosis |
| Illness management and recovery programme for people with severe mental illness |
| Illustrating Cochrane evidence in a more gentle way: Interview with Jen Ma |
| Iloperidone versus placebo for schizophrenia |
| Iloprost and cisaprost for Raynaud's phenomenon in progressive systemic sclerosis |
| Image-guided percutaneous renal core biopsy of small renal masses to diagnose renal cancer |
| Image-guided surgery for brain tumours |
| Image-guided surgery for brain tumours |
| Image-guided versus blind glucocorticoid injection for shoulder pain |
| Imaging guided surgery for brain tumours |
| Imaging techniques for antenatal detection of morbidly adherent placenta |
| Imaging tests for the non-invasive diagnosis of endometriosis |
| Imaging with positron emission tomography (PET) during chemotherapy to predict outcome in adults with Hodgkin lymphoma |
| Imaging-adapted therapy for individuals with Hodgkin lymphoma |
| Imatinib for treating patients with chronic myelogeneous leukemia |
| Imatinib mesylate for gastrointestinal stromal tumours (GISTs) |
| Imipramine for neuropathic pain in adults |
| Imiquimod for anogenital warts in non-immunocompromised adults |
| Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure |
| Immediate closure or delayed closure for treating traumatic wounds in the first 24 hours following injury |
| Immediate or delayed birth for a preterm fetus with suspected compromise |
| Immediate start of hormonal birth control |
| Immediate versus delayed reconstruction following surgery for breast cancer |
| Immersion in water in labour and birth |
| Immobilisation and functional treatment for acute lateral ankle ligament injuries in adults |
| Immobilisation versus early ankle movement for treating acute lateral ankle ligament injuries in adults |
| Immune checkpoint blockade for glioma |
| Immune checkpoint inhibitors (anti PD-1 or anti PD-L1) plus platinum-etoposide versus platinum-etoposide alone for first-line treatment of extensive small cell lung cancer |
| Immune checkpoint inhibitors (anti PD-1 or anti PD-L1) versus chemotherapy for second- or third-line treatment of metastatic non-small cell lung cancer |
| Immune checkpoint inhibitors and chemotherapy versus chemotherapy for early triple-negative breast cancer |
| Immune checkpoint inhibitors for advanced pancreatic cancer |
| Immune checkpoint inhibitors for unresectable hepatocellular carcinoma |
| Immune checkpoint inhibitors plus chemotherapy versus chemotherapy or immune checkpoint inhibitors for first- or second-line treatment of advanced gastric and gastro-esophageal junction cancer |
| Immune checkpoint inhibitors plus chemotherapy versus chemotherapy or immunotherapy for first-line treatment of advanced non-small cell lung cancer: a generic protocol |
| Immune system treatments other than corticosteroids, immunoglobulin and plasma exchange for CIDP |
| Immune therapies for women with history of failed implantation undergoing IVF treatment |
| Immune therapy for lumbosacral plexopathy (a condition that affects the network of nerves at the base of the spine) of unknown cause |
| Immune tolerance induction to destroy inhibitors in people with haemophilia A or B |
| Immune treatments for peripheral neuropathy caused by an IgM paraprotein antibody, which may bind to MAG, a protein on the myelin sheath of nerves |
| Immunity in vulnerable groups after COVID-19 vaccination |
| Immunoglobulin for alloimmune hemolytic disease in newborns |
| Immunoglobulin for myasthenia gravis |
| Immunoglobulin replacement to prevent infections in people with haematological malignancies and haematopoietic stem cell transplantation |
| Immunoglobulin treatment for Kawasaki disease |
| Immunoglobulins (human serum immune gamma globulins) seem effective for prevention of hepatitis A |
| Immunomodulators and immunosuppressants for progressive multiple sclerosis: a network meta-analysis |
| Immunomodulatory interventions (treatments that target the immune system) for focal epilepsy |
| Immunomodulatory treatment for amyotrophic lateral sclerosis/motor neuron disease |
| Immunonutrition as an adjuvant therapy for burns |
| Immunonutrition for acute respiratory distress syndrome (ARDS) in adults |
| Immunonutrition for patients undergoing surgery for head and neck cancer |
| Immunostimulants to prevent acute respiratory tract infections in children |
| Immunostimulating agents for the prevention of acute otitis media |
| Immunosuppressants to prevent corneal graft rejection after penetrating keratoplasty |
| Immunosuppressive agents for treating IgA nephropathy |
| Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis |
| Immunosuppressive and immunomodulatory therapies for idiopathic inflammatory myopathies |
| Immunosuppressive T cell antibody induction therapy for liver transplant recipients |
| Immunosuppressive therapy for IgA nephropathy in children |
| Immunosuppressive treatment for adults with idiopathic membranous nephropathy |
| Immunosuppressive treatment for focal segmental glomerulosclerosis in adults |
| Immunosuppressive treatment for people with proliferative lupus nephritis |
| Immunotherapy by allergen injections for seasonal allergic rhinitis ('hay fever') |
| Immunotherapy for advanced kidney cancer |
| Immunotherapy for advanced kidney cancer |
| Immunotherapy for intracranial metastatic melanoma |
| Immunotherapy for non-small cell lung cancer in the elderly population: a generic protocol |
| Immunotherapy for preventing allergic reactions to insect stings |
| Immunotherapy for recurrent miscarriage |
| Immunotherapy versus chemotherapy for people with advanced non-small cell lung cancer who have not been not previously been treated |
| Immunotherapy versus chemotherapy for treating inoperable or metastatic bladder cancer |
| Impact of computed tomography (CT) on lung cancer screening |
| Impact of diagnostic strategies for tuberculosis using lateral flow urine lipoarabinomannan test in people living with HIV |
| Impact of entertainment media smoking on adolescent smoking behaviours |
| Impact of epithelial ovarian cancer screening on patient-relevant outcomes in average-risk postmenopausal women |
| Impact of exposure to alcohol marketing and subsequent drinking patterns among youth and young adults |
| Impact of food fortification with multiple micronutrients on health |
| Impact of food fortified with vitamin D and Calcium on health outcomes |
| Impact of long-term opioid use for chronic non-cancer pain on misuse, abuse or addiction, overdose, falls and fractures |
| Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain |
| Impact of offering incentives in exchange for attending prenatal care visits on maternal and neonatal health outcomes |
| Impact of ovarian preservation on survival for women with endometrial carcinoma |
| Impact of shared scientific or ethical review of multicentre clinical research on the quality of clinical research and the clinical research process |
| Implantable cardiac monitors compared with conventional methods for the detection of atrial high-rate episodes in individuals with embolic stroke of undetermined source |
| Implantable cardioverter defibrillators versus medical therapy for people with inherited heart rhythm abnormalities |
| Implantable device monitoring versus usual care for managing individuals with heart failure |
| Implantable loop recorder versus conventional diagnostic assessment for people with unexplained recurrent fainting |
| Implantable miniature telescope for vision loss due to end-stage age-related macular degeneration |
| Implants in knee replacement surgery for patients with osteoarthritis and rheumatoid arthritis |
| Implants versus autologous tissue flaps for breast reconstruction following mastectomy |
| Implementation of treatment guidelines in mental health care |
| Implementation strategies for health systems in low-income countries |
| Important Cochrane Links |
| Important Update: Colloquium Cancelled |
| Improved learning with Cochrane Training website |
| Improving access to food in low- and middle-income countries |
| Improving adverse drug event reporting by health care professionals |
| Improving birth control use with programs based on theory |
| Improving healthcare workers' use of Standard Precautions to decrease infection in healthcare settings |
| Improving how antibiotics are prescribed by physicians working in the community. |
| Improving how physicians working in hospital settings prescribe antibiotics |
| Improving maternal, newborn and women's reproductive health in crisis settings |
| Improving outcomes for people with multiple chronic conditions |
| Improving palliative care for older people in care homes |
| Improving return to work in adults suffering from symptoms of distress |
| Improving surgical practice - a systematic review of effective education strategies to improve surgical technical skills in operative procedures |
| Improving the implementation of health-promoting policies and practices in workplaces |
| Improving the implementation of healthy eating, physical activity and obesity prevention policies, practices or programmes in childcare services |
| Improving the implementation of school-based policies and practices to improve student health |
| Improving the outcome of people with primary brain tumours and their carers using early palliative interventions |
| Improving vaccination uptake among adolescents |
| In adults, does oxygen therapy during the non-breathing period before intubation prevent complications? |
| In areas where malaria is common, malaria drug prophylaxis benefits people with sickle cell disease |
| In boys having circumcision the need for additional (rescue) analgesia is similar whether caudal or penile block is used |
| In children or grown-ups who have not been previously exposed to hepatitis B infection or whose exposure status is not known, hepatitis B vaccination as compared with no hepatitis B vaccination has an unclear effect on the risk of developing hepatitis B i |
| In children with liver disease, who have enlarged veins in the oesophagus (food pipe), does placing an elastic ring around the vein prevent it from bleeding? |
| In IVF, does transferring the embryo in media containing high concentrations of hyaluronic acid result in more live births? |
| In people undergoing emergency surgery to the chest or abdomen, how effective is transfusing a person's own blood compared with donor blood |
| In people who have had a heart attack because of blocked heart arteries insertion of thin metal tubes (stents) were better than using small balloons to open the arteries up again |
| In people with a bleeding ulcer in the stomach or duodenum there is no evidence of a difference in the risk of death if they are treated with a proton pump inhibitor, or an H2-receptor antagonist, or if they are given no specific drug treatment. However, |
| In people with asthma are single inhalers that contain both formoterol and budesonide better than current best practice? |
| In people with bone marrow disorders, a comparison of giving platelet transfusions only when bleeding occurs to also giving them to prevent bleeding |
| In preterm infants, how accurate are the blood tests BNP and NT-proBNP in identifying PDAs (patent ductus arteriosus) that require further treatment? |
| In stable COPD, should inhaled corticosteroids be used with combination long-acting beta2-agonist/long-acting muscarinic antagonist inhalers? |
| In the later stages of Parkinson's disease, side effects occur because of the use of levodopa in its treatment. These consist of involuntary writhing movements (dyskinesia), painful cramps in the legs and a shortened response to each dose referred to as ' |
| In the later stages of Parkinson's disease, side effects occur because of the use of levodopa in its treatment. These consist of involuntary writhing movements (dyskinesia), painful cramps in the legs and a shortened response to each dose referred to as ' |
| In vitro fertilisation compared to other options for unexplained subfertility |
| In vitro fertilisation versus tubal reanastomosis (sterilisation reversal) for subfertility after tubal sterilisation |
| In vitro maturation in subfertile women with polycystic ovarian syndrome who are undergoing assisted reproduction |
| In-bag manual versus uncontained power morcellation for laparoscopic myomectomy |
| In-hospital care pathways for stroke |
| In-service training for health professionals to improve care of seriously ill newborns and children in low-income countries |
| Inaugural Editor in Chief of Cochrane Clinical Answers announced |
| Incentive spirometry for prevention of postoperative pulmonary complications after upper abdominal surgery |
| Incentive-based and non-incentive-based interventions for increasing blood donation |
| Incentive-based interventions for increasing physical activity and fitness |
| Incentives and disincentives to participation by clinicians in randomised controlled trials |
| Incentives and enablers for improving patient adherence to tuberculosis diagnosis, prophylaxis, and treatment |
| Incentives for lay health workers to improve recruitment, retention in service and performance |
| Including chemotherapy in the treatment of high-grade glioma improves survival |
| Inconclusive evidence of the effectiveness of health and/or social interventions designed to help support the carers of people with Alzheimer's-type dementias. |
| Inconclusive findings on the effects of art therapy for people with dementia |
| Inconclusive, but promising evidence for the efficacy of functional analysis interventions for challenging behaviour in dementia |
| Increased energy intake for preterm infants with (or developing) bronchopulmonary dysplasia/ chronic lung disease |
| Increased fruit and vegetable intake to prevent cardiovascular disease |
| Increased police patrols for preventing alcohol-impaired driving |
| Increased salt in solution to maintain fluid during surgery |
| Increased water intake for preventing urinary stones |
| Increasing antipsychotic dose versus switching to a different antipsychotic for people with schizophrenia who do not respond to initial treatment |
| Increasing male involvement to improve women’s uptake of interventions to reduce the mother to child transmission of HIV |
| Increasing motorcycle and rider conspicuity for preventing death and injury in motorcyclists |
| Increasing pedestrian and cyclist visibility to prevent deaths and injuries |
| Increasing the dose of inhaled steroids or continuing the usual dose to treat asthma attacks in adults and children |
| Increasing the provision of physical activity advice by healthcare professionals |
| Increasing versus maintaining the dose of antipsychotic medication for people with schizophrenia who do not respond to treatment |
| Incremental versus standard dialysis for people with kidney failure |
| Indacaterol for the treatment of people with stable COPD |
| Independent living programmes for improving outcomes for young people leaving the care system |
| Indigenous healthcare worker involvement for indigenous adults and children with asthma |
| Individual or group antenatal education for childbirth or parenthood, or both |
| Individual Patient Education for low-back pain |
| Individual patient education for people with type 2 diabetes mellitus |
| Individual psychodynamic psychotherapy and psychoanalysis for schizophrenia and severe mental illness |
| Individual therapy for people diagnosed with cancer |
| Individual-, family-, and school-level interventions for preventing multiple risk behaviours relating to alcohol, tobacco and drug use in individuals aged 8 to 25 years |
| Individualized versus standard diet fortification for growth and development in very low birth weight infants receiving human milk |
| Indocyanine green angiography versus clinical evaluation in preventing postoperative complications following breast reconstruction after mastectomy |
| Indometacin in use as a single dose for treating acute postoperative pain |
| Indomethacin for asymptomatic patent ductus arteriosus in preterm infants |
| Indomethacin for controlling internal skull pressure in adults with severe traumatic brain injury |
| Indomethacin for treatment of symptomatic patent ductus arteriosus (PDA) in preterm infants |
| Indoor air modification interventions for prolonged non-specific cough in children |
| Indoor bathing in salt water followed by exposure to artificial ultraviolet B light for chronic plaque psoriasis |
| Indoor residual spraying for preventing malaria |
| Indoor residual spraying for preventing malaria |
| Induced hypertension for preventing complications of delayed cerebral ischaemia in aneurysmal subarachnoid haemorrhage |
| Induced hypotension with propofol under anaesthesia during endoscopic sinus surgery |
| Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy with or without adjuvant chemotherapy for locally advanced nasopharyngeal carcinoma |
| Induction methods for women who have had a prior caesarean birth |
| Induction of labour at or near the end of pregnancy for babies suspected of being very large (macrosomia) |
| Induction of labour in women with normal pregnancies at or beyond 37 weeks |
| Industry sponsorship and research outcome |
| Infant pacifiers for reduction in risk of sudden infant death syndrome |
| Infection control strategies for preventing the spread of meticillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people |
| Infection risk after surgery in patients using medications for inflammatory bowel disease |
| Infliximab for rheumatoid arthritis |
| Infliximab for the maintenance of successful treatment in Crohn's Disease |
| Infliximab for the treatment of active Crohn's disease |
| Influence of beta-blockers on perioperative adverse events |
| Influenza (flu) vaccination for preventing influenza in adults with cancer |
| Influenza is an acute infection of the airways and the whole body, caused by a virus |
| Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions |
| Influenza vaccination in children being treated with chemotherapy for cancer |
| Influenza vaccine for children and adults with bronchiectasis |
| Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) |
| Influenza vaccine for people with HIV/AIDS |
| Influenza vaccine for preventing acute otitis media (middle ear infection) |
| Information and communication technologies (ICT) for promoting sexual and reproductive health (SRH) and preventing HIV infection in adolescents and young adults |
| Information and communication technology-based cognitive remediation for supporting treatment compliance for people with serious mental illness |
| Information and promotional strategies by pharmaceutical companies for clinicians |
| Information for adult intensive care unit patients and their carers |
| Information for Journalists |
| Information provision to help people with multiple sclerosis make informed decisions |
| Information to encourage pregnant women to attempt vaginal birth has not been shown to change caesarean birth rates |
| Informing consumers about how well birth control works |
| Infraorbital nerve block for pain after cleft lip surgery in children |
| Infusion techniques for peripheral arterial thrombolysis |
| Inhaled analgesia for relieving pain during labour |
| Inhaled beclomethasone compared with placebo for chronic asthma |
| Inhaled beta2-agonists for asthma in mechanically ventilated patients |
| Inhaled beta2-agonists for non-specific chronic cough in children |
| Inhaled corticosteroid effects on bone metabolism in asthma and mild chronic obstructive pulmonary disease |
| Inhaled corticosteroids compared to placebo for prevention of exercise induced bronchoconstriction |
| Inhaled corticosteroids compared with placebo for stable chronic obstructive pulmonary disease (COPD) |
| Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing |
| Inhaled corticosteroids for acute asthma following emergency department discharge |
| Inhaled corticosteroids for adults with cough lasting over three weeks |
| Inhaled corticosteroids for cystic fibrosis |
| Inhaled corticosteroids for subacute cough in children |
| Inhaled corticosteroids for treating non-specific chronic cough in children |
| Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma |
| Inhaled cromones for prolonged non-specific cough in children |
| Inhaled drugs for opening up the airways in cases of acute chest syndrome in people with sickle cell disease |
| Inhaled drugs to open up the airways of people with cystic fibrosis |
| Inhaled fluticasone versus 'extrafine' HFA-beclomethasone dipropionate for chronic asthma in adults and children |
| Inhaled hyperosmolar agents for bronchiectasis |
| INHALED INSTEAD OF INJECTED SHORT-ACTING INSULIN APPEARS NO MORE EFFECTIVE FOR GLYCAEMIC CONTROL BUT MAY BE PREFERRED BY PEOPLE WITH DIABETES |
| Inhaled moist air for croup probably provides no benefit in emergency settings |
| Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease |
| Inhaled nitric oxide for respiratory failure in preterm infants |
