| Is a 'quick diagnosis' test on an ovarian mass during surgery accurate? |
| Is a procedure to induce tolerance for aspirin an effective treatment for adults with a hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs)? |
| Is adding an anti-leukotriene to an inhaled corticosteroid better than using an inhaled corticosteroid alone for persistent asthma? |
| Is adding an anti-leukotriene to an inhaled corticosteroid better than using an inhaled corticosteroid alone in children with persistent asthma? |
| Is adding focused radiation (radiosurgery) to whole brain radiation therapy beneficial to people with brain metastases? |
| Is alpha-lipoic acid (a natural antioxidant) better than no treatment or dummy treatment for nerve damage in people with diabetes? |
| Is alpha-lipoic acid (a natural antioxidant) better than no treatment or dummy treatment for nerve damage in people with diabetes? |
| Is antibiotic prophylaxis effective or safe for women undergoing operative vaginal delivery? |
| Is artificial intelligence (AI) better than humans for diagnosing the eye condition 'exudative age-related macular degeneration'? |
| Is artificial intelligence (AI) better than humans for diagnosing the eye condition 'exudative age-related macular degeneration'? |
| Is attachment of the excretory duct of the pancreas to the second part of the small intestine better than other reconstruction methods to reduce leakage of juice from the pancreas to the abdominal tissues? |
| Is automated peritoneal dialysis better than continuous ambulatory peritoneal dialysis for people with kidney failure? |
| Is bed sharing an effective and safe method in the care of healthy term neonates? |
| Is breathing retraining useful in the treatment of children with dysfunctional breathing/hyperventilation syndrome? |
| Is carvedilol more effective or safer than traditional, non-selective beta-blockers for people with cirrhosis and gastroesophageal varices? |
| Is changing dietary fat intake beneficial or harmful for people with gallstones? |
| Is chemotherapy beneficial to patients with brain metastases from small cell lung cancer? |
| Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus? |
| Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus? |
| Is Cognitive behavioural therapy as effective as other psychosocial treatments for people with schizophrenia |
| Is Cognitive behavioural therapy as effective as standard care for people with schizophrenia |
| Is colchicine an effective treatment for people with COVID-19? |
| Is continuing chronic blood thinners better than stopping them near or during surgical heart rhythm device implantation? |
| Is continuous positive airway pressure (CPAP) during the postoperative period useful? |
| Is continuous renal replacement therapy beneficial for people with rhabdomyolysis? |
| Is Cyclamen europaeum extract effective for people with acute sinusitis? |
| Is D-cycloserine effective and safe for social and communication skills deficits in people with ASD? |
| Is dance movement therapy an effective intervention for dementia? |
| Is dance movement therapy an effective intervention for dementia? A review of the evidence |
| Is dance movement therapy an effective treatment for depression? A review of the evidence |
| Is dexmedetomidine a good option for patients undergoing awake fibreoptic intubation? |
| Is e-learning more effective than traditional learning for health professionals? |
| Is early or late tracheostomy more effective in critically ill COVID-19 patients who are expected to require long-term artificial ventilation? |
| Is electrical stimulation effective for treating pressure ulcers? |
| Is endometrial resection or ablation more effective, safer or more acceptable than different routes of hysterectomy? |
| Is entecavir better than no treatment or placebo for treating people with chronic hepatitis B? |
| Is evacuation proctogram still the reference standard for diagnosis of posterior pelvic floor disorders in women with obstructed defaecation syndrome? |
| Is exercise an effective therapy to treat knee osteoarthritis? |
| Is exercise of the pelvic floor muscles more effective for treating unintentional passing of urine (incontinence) in women when feedback or biofeedback are added? |
| Is extending the treatment time by specialist mental health teams better for people with recent-onset psychosis? |
| Is face-down positioning better than other positioning after vitrectomy and gas tamponade for macula-involving rhegmatogenous retinal detachments? |
| Is favipiravir useful in treating people with COVID‐19? |
| Is fenofibrate effective for diabetic retinopathy? |
| Is general anesthesia or loco-regional anesthesia better for people needing an endovascular repair of an aortic aneurysm? |
| Is giving breathing support through the nose effective in babies that need help breathing at birth? |
| Is home haemodialysis better than in-centre haemodialysis for people with kidney failure? |
| Is home or hospital treatment better for people with blood clots in the lungs? |
| Is immunotherapy plus chemotherapy better than chemotherapy alone for older people with non-small cell lung cancer? |
| Is inhaled magnesium sulfate a safe and effective treatment for people with asthma attacks? |
| Is intravenous immunoglobulin safe and effective for people with chronic inflammatory demyelinating polyradiculoneuropathy? |
| Is it better for a baby to be born immediately or to wait for labour to start spontaneously when waters break at or after 37 weeks? |
| Is it better for the baby to be born immediately or wait for labour to start if the waters break without contractions before 37 weeks of pregnancy? |
| Is it better to add long-acting muscarinic antagonists or long-acting beta2-agonists to inhaled corticosteroids for people with uncontrolled asthma? |
| Is it better to do strabismus (squint) surgery before or after completing amblyopia (lazy eye) treatment? |
| Is it better to eat food early or wait for at least 24 hours after major gynaecologic surgery? |
| Is it better to insert an implant or intrauterine device (coil) for contraception within days of childbirth or wait 4 to 6 weeks? |
| Is it better to take blood pressure-lowering medicines in the morning or evening to treat high blood pressure? |
| Is it better to take statins before undergoing heart-related surgery? |
| Is it safe to use lower blood counts (haemoglobin levels) as a trigger for blood transfusion in order to give fewer blood transfusions? |
| Is it safe to use lower blood counts as a trigger for blood transfusion? |
| Is it safer to deliver a baby immediately or wait if the mother has high blood pressure after 34 weeks of pregnancy that is not persistently severe? |
| Is keeping the azygos vein intact during surgery for newborns with esophageal atresia beneficial? |
| Is L-acetylcarnitine an effective treatment for fragile X syndrome? |
| Is limiting the amount of fluid given to adults during surgery as good as using haemodynamic monitoring, which continuously measures changes in blood pressure or speed of blood flow inside the arteries, to guide fluid administration? |
| Is LipiFlow more effective than other dry eye disease treatments? |
| Is local or general anaesthesia better during surgery to widen the main blood vessel to the brain when it becomes narrowed (carotid endarterectomy)? |
| Is local or major surgery better for treating early rectal cancer with or without additional treatments before or after surgery? |
| Is magnesium sulfate effective for chronic obstructive pulmonary disease (COPD) flare-ups? |
| Is magnesium sulphate for women at risk of preterm birth better than placebo for protecting their babies' brains? |
| Is magnesium sulphate for women at risk of preterm birth better than placebo for protecting their babies' brains? |
| Is magnetic seizure therapy an effective add-on treatment for people with treatment-resistant depression? |
| Is maintenance therapy following previous treatment better than observation or placebo for treating chronic lymphocytic leukaemia in adults? |
| Is measuring bilirubin levels through the skin a reliable alternative to measuring bilirubin levels in the blood of newborns? |
| Is metformin an effective treatment for adults with type 2 diabetes? |
| Is methylphenidate an effective treatment for children and adolescents with attention deficit hyperactivity disorder (ADHD) and does it cause unwanted effects? |
| Is methylphenidate an effective treatment for children and adolescents with attention deficit hyperactivity disorder (ADHD) and does it cause unwanted effects? |
| Is omega-3 polyunsaturated fatty acid supplementation better than a placebo for treating depression among children and adolescents? |
| Is once-daily ICS/LABA combined in one inhaler more beneficial than inhaled LAMA for treatment of people with COPD? |
| Is plasma from the blood of people who have recovered from COVID-19 an effective treatment for other people with COVID-19? |
| Is prostate MRI, with or without MRI-targeted biopsy, better than systematic biopsy for detecting prostate cancer in men? |
| Is recent-onset psychosis best treated by a specialist mental health team? |
| Is repetitive transcranial magnetic stimulation (rTMS) an effective and safe treatment for adults with post-traumatic stress disorder (PTSD)? |
| Is resistance training an effective treatment for fatigue in people diagnosed with cancer? |
| Is rituximab better for people with multiple sclerosis than other disease-modifying medicines? |
| Is routine veno-venous bypass necessary in liver transplantation? |
| Is shock wave treatment better than surgical procedures for removing kidney stones? |
| Is shock wave treatment better than surgical procedures for removing kidney stones? |
| Is silver diamine fluoride varnish an effective treatment for preventing and managing tooth decay in children and adults? |
| Is siponimod an effective treatment for multiple sclerosis (MS) and does it cause unwanted effects? |
| Is skin puncture better than exposing the femoral artery for minimally invasive repairs of abdominal aortic aneurysms? |
| Is skin-sparing mastectomy an effective and safe surgical procedure for the treatment of breast cancer? |
| Is sodium bicarbonate therapy helpful for people with acute kidney problems? |
| Is stretch effective for treating and preventing joint deformities? |
| Is supervised maintenance after pulmonary rehabilitation effective compared to usual treatment in people with chronic obstructive pulmonary disease? |
| Is supplemental nutrition before surgery better than a regular diet for people having surgery on the digestive system? |
| Is surgery or observation better for people who have a severe blunt injury to the liver? |
| Is surgery with a high-pressure water jet (hydrosurgery) better than conventional surgery for early treatment of mid-depth burns? |
| Is switching to a different antipsychotic medicine better than continuing with the same one for people with non-responsive schizophrenia? |
| Is taking an immunostimulant on top of standard medications beneficial for people with chronic obstructive pulmonary disease, chronic bronchitis, or both? |
| Is taking inhaled corticosteroids only when asthma symptoms get worse as safe and effective as taking inhaled corticosteroids every day? |
| Is the blood pressure lowering effect of dihydropyridine calcium channel blockers consistent or variable throughout 24 hours? |
| Is the blood pressure-lowering effect of beta-blockers with partial agonist activity consistent or variable throughout the day? |
| Is the combination of nirmatrelvir plus ritonavir effective for treating or preventing COVID-19? |
| Is the McKenzie method effective for the treatment of (sub)acute non-specific low back pain? |
| Is the outcome of severe postoperative eye infection improved by early surgery to remove the vitreous gel? |
| Is the use of a constricting device (tourniquet) during amputation safe and effective in reducing complications? |
| Is the use of antibiotics beneficial for treating leptospirosis? |
| Is the use of continuous infusion of loop diuretics better than bolus injections for acute heart failure? |
| Is the workplace an effective setting for helping people to stop smoking |
| Is there a benefit of implanting a mobile disc prosthesis over traditional fusion surgery for treatment of a herniated disc in the neck? |
| Is there a benefit of using a lower red blood cell level (restrictive) compared to a higher red blood cell level (liberal) to determine the need for red blood cell transfusion in patients diagnosed with blood cancers (e.g. leukaemia, lymphoma, myeloma) re |
| Is there a best way to remove dead tissue from surgical wounds? |
| Is there a difference between pars plana vitrectomy with internal limiting membrane flap and pars plana vitrectomy with internal limiting membrane peeling for large macular holes? |
| Is there a difference in outcome when a surgeon makes a single cut rather than several cuts to perform keyhole surgery to remove an appendix for suspected appendicitis? |
| Is there an increased risk of ovarian cancer in women treated with drugs for subfertility? |
| Is three-dimensional saline infusion sonography (3D SIS) better than two-dimensional (2D) SIS for detecting polyps and fibroids? |
| Is transarterial (chemo)embolisation better than systemic chemotherapy for treating bowel cancer that has spread to the liver? |
| Is treatment with corticosteroids beneficial and safe for people with pneumonia? |
| Is ultrasound alone or in combination with other methods useful for confirmation of gastric tube placement? |
| Is ultrasound guidance a good option for peripheral intravenous cannulation in adults? |
| Is ultrasound guidance a good option for peripheral intravenous cannulation in adults? |
| Is urgent-start peritoneal dialysis safe for patients with chronic kidney disease? |
| Is vitamin D an effective and safe addition to antibiotics for treating children with acute pneumonia? |
| Is vitamin D an effective and safe treatment for COVID-19? |
| Is voriconazole better than amphotericin B or fluconazole to prevent and treat fungal infections in cancer patients with poor immune defence systems |
| Is water fluoridation effective in preventing tooth decay? |
| Is water-based exercise an effective and safe type of exercise for adults with asthma? |
| Is withdrawal of drug therapy feasible in patients with CD who have achieved remission? |
| Is X-ray treatment (radiotherapy) after removal of breast tissue (mastectomy) better than no X-ray treatment in women diagnosed with breast cancer that has spread to one to three armpit lymph nodes? |
| Is zinc supplementation effective for preventing death and disease, and for promoting growth, in children aged 6 months to 12 years and does it cause unwanted effects? |
| Is ‘prophylactic transarterial embolization’ (blocking blood vessels as a precaution) effective to prevent a peptic (stomach) ulcer bleeding again following earlier successful endoscopic treatment (with a tube through the mouth into the stomach)? |
| Is “eating for two” a good idea? Maintaining a healthy weight during pregnancy helps mother and baby |
| Ischaemic preconditioning for heart surgery |
| Isocaloric balanced protein supplementation in pregnancy |
| Isoflavones for hypercholesterolaemia |
| Isokinetic exercise for improving knee flexor and extensor muscles |
| Isolation as a strategy for controlling the transmission of hepatitis C virus (HCV) infection in haemodialysis units |
| Isometric exercise training for hypertension |
| Isoniazid is effective in helping to prevent tuberculosis in people not infected with HIV |
| Isoniazid prophylaxis for preventing active tuberculosis and death in HIV-positive children |
| Isoprinosine for chronic hepatitis B |
| Isoprinosine versus other antiviral drugs for chronic hepatitis B |
| iStent for open-angle glaucoma |
| It is not yet clear whether adding chemotherapy (anti-cancer drugs) to another treatment for a recurrence of breast cancer in the same area improves survival |
| It is premature to draw conclusions about the effectiveness of MST compared with other services |
| Ivabradine as adjuvant treatment for chronic heart failure |
| Ivabradine as adjuvant treatment for chronic heart failure |
| Ivacaftor (marketed as Kalydeco®), a new specific therapy for cystic fibrosis |
| Ivermectin and permethrin for treating scabies |
| Ivermectin for preventing and treating COVID-19 |
| Ivermectin for preventing and treating COVID-19 |
| Ivermectin for preventing and treating COVID-19 |
| Ivermectin for river blindness (onchocerciasis) |
| Ivermectin versus benzimidazoles for treating Strongyloides stercoralis infection |
| Ivermectin: Cochrane’s most talked about review so far, ever. Why? |
| Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis |
| Jimmy Volmink recognized for his “exceptional lifelong contribution to medical research and public health" |
| Join Cochrane |
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| Joint Cochrane Oral Health Co-ordinating Editor, Helen Worthington, awarded BDA's 2019 John Tomes Medal |
| Joint corticosteroid injection for knee osteoarthritis |
| Joint lavage for osteoarthritis of the knee |
| Jolt accentuation of headache as a test for acute meningitis in emergency settings |
| Jordi Pardo Pardo announced as new Cochrane Governing Board interim Chair |
| Kangaroo mother care to reduce morbidity and mortality in low birthweight infants |
| Kava extract for treating anxiety |
| Keeping Cochrane evidence up-to-date |
| Ketamine and other glutamate receptor modulators for bipolar depression |
| Ketamine and other glutamate receptor modulators for depression in adults |
| Ketamine and other NMDA receptor antagonists for chronic pain |
| Ketamine and propofol in combination for adult procedural sedation and analgesia in the emergency department |
| Ketamine venous injection for acute pain after operation in adults |
| Ketanserin is a drug that has been studied in the treatment of Raynaud's phenomenon and associated conditions. It is not widely used however. |
| Ketogenic diet for primary brain and spinal cord tumours |
| Ketogenic diets for drug-resistant epilepsy |
| Ketorolac for short-term pain after surgery in children |
| Ketotifen alone or as additional medication for long-term control of asthma and wheeze in children |
| Key hole-assisted vaginal extended (radical) hysterectomy versus open radical hysterectomy for the treatment of early cervical cancer |
| Key-hole (laparoscopic) versus standard access (open) abdominal operation for people with pancreatic cancer |
| Key-hole (laparoscopic) versus standard cut (open) abdominal surgery for people with food-pipe (oesophageal) cancer |
| Keyhole (laparoscopic) surgery through the abdomen for treating urinary incontinence in women |
| Keyhole (laparoscopic) versus traditional (open) surgery for people donating a kidney |
| Keyhole laparoscopic or open surgery for rectal cancer |
| Keyhole surgery versus medical treatment for adults with heart burn or acid regurgitation |
| Killed whole cell or other inactive subunit vaccines (injected) for preventing cholera |
| Kinesio taping for rotator cuff disease |
| Kinesthetic stimulation for preventing apnea in preterm infants |
| Kinesthetic stimulation for treating apnea in preterm infants |
| Kinesthetic stimulation versus theophylline for apnea in preterm infants |
| Kinin-enhancing drugs for unexplained subfertility in men |
| Kinship care for the safety, permanency, and well-being of maltreated children |
| Knee braces, sleeves or straps for treating anterior knee pain (patellofemoral pain syndrome) |
| Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in postoperative surgical patients |
| Knowledge Translation in Cochrane Request for Proposal - Principles of Dissemination |
| Knowledge translation interventions for facilitating evidence-informed decision-making amongst health policymakers |
| L-carnitine for cognitive enhancement in people without cognitive impairment |
| L-ornithine L-aspartate for people with chronic liver disease and hepatic encephalopathy (poor brain functioning) |
| L-ornithine-L-aspartate for hepatic encephalopathy |
| LAAM may be more effective at reducing heroin dependence than methadone, but it is associated with adverse effects, some of which may be life-threatening |
| Laboratory blood, urine tests and liver biopsy used for the diagnosis of Wilson's disease in children and adults |
| Laboratory tests for diagnosis of congenital Zika virus in fetuses and neonates |
| Labour assessment programs to delay admission to labour wards |
| Laceback ligatures for controlling anchorage in patients undergoing fixed orthodontic treatment |
| Lacosamide add-on therapy for focal epilepsy |
| Lacosamide for neuropathic pain and fibromyalgia in adults |
| Lacosamide monotherapy for epilepsy |
| Lactase treated feeds to promote growth and feeding tolerance in preterm infants |
| Lactational amenorrhoea method for family planning |
| Laetrile treatment for cancer |
| Lamivudine during pregnancy for preventing hepatitis B virus infection in newborns |
| Lamivudine for chronic hepatitis B in adults |
| Lamivudine for preventing reactivation of hepatitis B infection in patients planned to undergo immunosuppressive therapy |
| Lamivudine with or without adefovir dipivoxil for postoperative hepatocellular carcinoma |
| Lamotrigine (an antiepileptic drug) for chronic neuropathic pain or fibromyalgia |
| Lamotrigine add-on therapy for drug-resistant focal epilepsy |
| Lamotrigine as a treatment for prevention of recurrence of bipolar disorder |
| Lamotrigine as add-on therapy for drug-resistant generalised tonic-clonic seizures |
| Lamotrigine for schizophrenia |
| Lamotrigine versus carbamazepine monotherapy (single medication treatment) for epilepsy |
| Laparoendoscopic single-site donor nephrectomy (LESS-DN) versus standard laparoscopic donor nephrectomy |
| Laparoscopic (key hole) operation versus open operation for treatment of people with stomach cancer |
| Laparoscopic (minimally invasive) repair for perforated peptic ulcer disease |
| Laparoscopic and open cholecystectomy seem equivalent considering complications and operative time, but laparoscopic cholecystectomy is associated with quicker recovery |
| Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer |
| Laparoscopic and small-incision cholecystectomy seem equivalent in complications and recovery, but small-incision cholecystectomy is quicker to perform |
| Laparoscopic application of heat or laser to the ovaries to cause ovulation in women with polycystic ovary syndrome who do not ovulate |
| Laparoscopic cardiomyotomy versus endoscopic pneumatic dilation for primary achalasia |
| Laparoscopic entry techniques |
| Laparoscopic fundoplication for gastro-oesophageal reflux disease (GORD) in adults |
| Laparoscopic radical cystectomy for bladder cancer |
| Laparoscopic surgery compared to open surgery for suspected appendicitis |
| Laparoscopic surgery for abdominal aortic aneurysm |
| Laparoscopic surgery for benign ovarian tumours is associated with less pain, shorter hospital stay, and fewer adverse events than with laparotomy |
| Laparoscopic surgery for pain and infertility associated with endometriosis |
| Laparoscopic surgery for presumed benign ovarian tumor during pregnancy |
| Laparoscopic surgery may be of benefit in treating subfertility associated with mild to moderate endometriosis |
| Laparoscopic surgery reduces pelvic pain caused by endometriosis. |
| Laparoscopic surgery versus open surgery for acute sigmoid diverticulitis |
| Laparoscopic surgical box model training for surgical trainees with limited prior laparoscopic experience |
| Laparoscopic surgical box model training for surgical trainees with no prior laparoscopic experience |
| Laparoscopic techniques versus open techniques for repair of a hernia in the groin |
| Laparoscopic versus open liver resection for benign and malignant hepatic lesions in adults |
