Treatment of enteric fever (typhoid and paratyphoid fever) with third and fourth generation cephalosporins

To evaluate third and fourth generation cephalosporins in the treatment of enteric fever in children and adults compared with other antibiotics. The primary objectives are:

  • to identify whether the drugs under scrutiny are clinically effective
  • which is the optimal agent and at what dose
  • what is the most appropriate route of administration
  • what is the ideal treatment duration

Therefore, we will perform within-class comparisons and an assessment of third and fourth generation cephalosporin treatment duration.

This is a protocol.