| Laparoscopic surgery versus open surgery for acute sigmoid diverticulitis |
| Laparoscopic surgical box model training for surgical trainees with limited prior laparoscopic experience |
| Laparoscopic surgical box model training for surgical trainees with no prior laparoscopic experience |
| Laparoscopic techniques versus open techniques for repair of a hernia in the groin |
| Laparoscopic versus open liver resection for benign and malignant hepatic lesions in adults |
| Laparoscopic versus open resection for gastric gastrointestinal stromal tumours (GISTs) |
| Laparoscopic-endoscopic rendezvous or preoperative endoscopic sphincterotomy before removing the gallbladder for gall stones or bile duct stones |
| Laparoscopy ( "keyhole" surgery ) has fewer complications than other forms of tubal ligation ( tying the tubes for contraception ), but requires more skills and equipment |
| Laparoscopy in diagnosing extensiveness of ovarian cancer |
| Laparoscopy versus laparotomy (open surgery) for early-stage ovarian cancer |
| Laparoscopy versus laparotomy for the management of presumed early stage endometrial cancer |
| Lapatinib for advanced breast cancer overexpressing HER2 |
| Laquinimod, a new oral disease-modifying drug for multiple sclerosis (MS) |
| Larger versus smaller dose of the same drug/s regimen for metastatic breast cancer |
| Larger versus smaller red blood cell volume per transfusion in hospitalized adults, children, and preterm neonates |
| Larviciding to control malaria |
| Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants with, or at risk of, respiratory distress syndrome |
| Laryngeal mask airway versus bag-mask ventilation or endotracheal intubation for neonatal resuscitation |
| Laryngeal mask airway versus endotracheal tube for percutaneous dilatational tracheostomy in critically ill adults |
| Laser or vitrectomy for vitreous floaters |
| Laser photocoagulation for diabetic retinopathy |
| Laser photocoagulation for proliferative diabetic retinopathy |
| Laser photocoagulation for treating choroidal new vessels near the centre of the retina in people with high myopia |
| Laser photocoagulation for treating neovascular age-related macular degeneration |
| Laser photocoagulation versus transscleral cryotherapy for threshold retinopathy of prematurity |
| Laser prostatectomy for benign prostatic obstruction |
| Laser surgery for glaucoma that lowers eye pressure by destroying a part of the eye responsible for production of fluid inside the eye |
| Laser surgery that lowers eye pressure by destroying a part of the eye that produces fluid inside the eye for people with uncontrolled glaucoma |
| Laser therapy for carpal tunnel syndrome |
| Laser therapy for hypertrophic and keloid scars |
| Laser therapy for hypertrophic and keloid scars |
| Laser therapy for retinopathy in sickle cell disease |
| Laser trabeculoplasty for open-angle glaucoma |
| Laser treatment for acne scars |
| Laser treatment of drusen to prevent progression to advanced age-related macular degeneration |
| Laser versus non-laser endonasal dacryocystorhinostomy |
| Laser-assisted cataract surgery versus standard ultrasound phacoemulsification cataract surgery |
| Laser-assisted in-situ keratomileusis (LASIK) compared to photorefractive keratectomy (PRK) for correcting short-sightedness |
| Lasers for the removal of decay in first and permanent teeth |
| Late (from the age of seven days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants |
| Late erythropoiesis-stimulating agents to prevent red blood cell transfusion in preterm or low birth weight infants |
| Late versus early surgical correction for congenital diaphragmatic hernia in newborn infants |
| Later school start times for supporting the education, health, and well-being of high school students |
| Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in people living with HIV |
| Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation |
| Lateral positioning for critically ill adult patients |
| Lateral tilt for caesarean section |
| Latest Cochrane Review finds high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapy (NRT) in helping people quit smoking |
| Latest health evidence shows that making changes to diet, physical activity and behaviour may reduce obesity in children and adolescents |
| Launch of Cochrane Cameroon celebrated |
| Launch of Cochrane Colombia to support the use of high quality, trusted health information |
| Launch of Cochrane Dominican Republic |
| Launch of Cochrane First Aid |
| Launch of Cochrane Global Mental Health |
| Launch of Cochrane Indonesia to boost production and use of trusted health evidence in Indonesia |
| Launch of Cochrane US Network |
| Launch of Cochrane’s Dissemination Checklist and Guidance |
| Launch of Evidence Essentials 5: Consumer involvement in Cochrane |
| Launch of new Cochrane Sustainable Healthcare Field |
| Launching Cochrane methods guidance in Russian |
| Launching Cochrane methods guidance in Spanish and Japanese |
| Launching Cochrane Portugal to support the use of high quality, trusted health information |
| Laxatives for the management of childhood constipation |
| Laxatives for the management of constipation in people receiving palliative care |
| Laxatives for the treatment of hemorrhoids |
| LCZ696 (sacubitril/valsartan) for patients with heart failure |
| Lead author of ‘Interventions for increasing the use of shared decision making by healthcare professionals’ discusses Cochrane Review |
| Lean management in health care: effects on patient outcomes, professional practice, and healthcare systems |
| Learning about Cochrane in 6 South Asian languages |
| Leeches (Hirudinea) for osteoarthritis |
| Leflunomide for the treatment of rheumatoid arthritis |
| Left atrial appendage closure versus oral anticoagulation for preventing stroke in people with atrial fibrillation |
| Legal banning of asbestos for preventing asbestos exposure |
| Lenalidomide for red blood cell transfusion dependent IPSS low- or intermediate-1-risk myelodysplastic syndromes |
| Length of stay in hospital for people with severe mental illness |
| Length of time needed for antibiotic treatment given directly into the blood stream to clear acute chest infections in people with cystic fibrosis |
| Length of treatment with vitamin K antagonists and prevention of recurrence in patients with venous thromboembolism |
| Lens extraction compared with laser peripheral iridotomy to treat acute primary angle closure |
| Leptin for overweight and obesity |
| Less extensive surgery for vulvar cancer appears safe and limits mutilation |
| Less intensive versus conventional haemodialysis for people with end-stage kidney disease |
| Let's talk e-cigarettes Podcast |
| Leukodepletion for patients undergoing heart valve surgery |
| Leukotriene inhibitors for bronchiolitis in infants and young children |
| Leukotriene receptor antagonist for prolonged non-specific cough in children |
| Leukotriene receptor antagonists for non-cystic fibrosis bronchiectasis |
| Leukotriene receptor antagonists for rhinosinusitis |
| Levamisole for chronic hepatitis B |
| Levels of interleukin-6 in identifying severely ill adult patients with sepsis |
| Levetiracetam add-on for drug-resistant focal epilepsy |
| Levetiracetam for neuropathic pain in adults |
| Levetiracetam monotherapy for epilepsy |
| Levodopa for restless legs syndrome |
| Levomepromazine for schizophrenia |
| Levomepromazine for the treatment of nausea and vomiting in people with advanced disease |
| Levonorgestrel intrauterine system (LNG-IUS) for endometrial protection in women with breast cancer taking tamoxifen to prevent recurrence |
| Levosimendan to prevent reduced heart function and death after heart surgery in infants and children with congenital heart disease |
| Lexipafant for acute pancreatitis |
| Lidocaine for pain relief in people with burns |
| Lidocaine for prevention of a sore throat following an operation under general anaesthetic |
| Lidocaine for reducing propofol-induced pain on anaesthesia in adults |
| Lidocaine-prilocaine cream for analgesia during circumcision in newborn boys |
| Life After Stroke |
| Life skills programmes for chronic mental illnesses |
| Life-style modification, non-pharmacological and pharmacological strategies for obese subfertile women |
| Lifestyle changes for treating psoriasis |
| Lifestyle interventions for chronic gout |
| Lifestyle interventions for the treatment of urinary incontinence in adults |
| Lifestyle interventions for treating acute gout attacks |
| Lifestyle interventions for treating women with gestational diabetes (or diabetes in pregnancy) |
| Lifestyle modification strategies for managing obstructive sleep apnoea |
| Lifestyle modifications for people with nonalcohol-related fatty liver disease |
| Ligasure vessel-sealing system or harmonic scalpel versus conventional vessel ligation for thyroidectomy |
| Light therapy for prevention of winter depression |
| Light treatment for non-seasonal depression |
| Light-based tests for the detection and diagnosis of early tooth decay |
| Lightweight versus Heavyweight mesh for laparoscopic repair of inguinal hernia |
| Lightweight versus Heavyweight mesh for open repair of inguinal hernia |
| Limb salvage for treating pathological fracture at diagnosis in children and adolescents with localized high grade osteosarcoma |
| Limited (information only) patient education programs for adults with asthma |
| Limited data supports use of urinary alkalinisation for the treatment of acute chlorophenoxy herbicide poisoning. |
| Limited evidence of effectiveness of physostigmine for the symptomatic treatment of Alzheimer's disease |
| Limited evidence that propentofylline benefits cognition, global function and activities of daily living in people with Alzheimer's disease and/or vascular dementia |
| Limited resections versus lobectomy for stage I non-small cell lung cancer |
| Limited symptom relief is available for women with chronic pelvic pain |
| Linezolid for managing people with drug-resistant tuberculosis |
| Linked color imaging versus conventional white light colonoscopy for the detection of colorectal polyps |
| Lipid-lowering agents for nephrotic syndrome |
| Lipid-lowering for peripheral arterial disease of the lower limb |
| Liposomal bupivacaine as a nerve block to treat pain after surgery |
| Liposomal bupivacaine at the site of surgery to treat pain |
| List of countries eligible for free one-click access to the Cochrane Library in 2019 |
| Lisuride for levodopa-induced complications in Parkinson's disease |
| Lisuride versus bromocriptine for levodopa-induced complications in Parkinson's disease |
| Lithium for maintenance treatment of mood disorders |
| Lithium for schizophrenia |
| Lithium for the treatment of acute mania |
| Lithium versus antidepressants in the long-term treatment of unipolar affective disorder |
| Little evidence that antibiotics or alpha-blocker drugs help to relieve chronic abacterial prostatitis, but heat treatments might be effective and more research is needed. |
| Little evidence that burns patients benefit from hyperbaric oxygen therapy |
| Live micro-organisms for prevention or treatment of diarrhoea in people with cancer who are treated with chemotherapy or radiotherapy |
| Liver and spleen stiffness as assessed by vibration controlled transient elastography for diagnosing clinically significant portal hypertension in comparison with other elastography-based techniques in adults with chronic liver disease |
| Liver and spleen stiffness for the diagnosis of oesophageal varices in adults with chronic liver disease |
| Liver support systems for adults with acute liver failure |
| Liver support systems for adults with acute-on-chronic liver failure |
| Livestock development programmes for communities in low- and middle-income countries |
| Living Systematic Review: Interventions for increasing fruit and vegetable consumption in children aged five years and under |
| Living Systematic Review: Pharmacological treatments for psoriasis, network meta analysis |
| Local anaesthesia (numbing medicine) that is directly applied to the skin can provide pain control for repair of skin lacerations |
| Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity |
| Local anaesthetic nerve block for pain management in labour |
| Local anaesthetic sympathetic blockade for complex regional pain syndrome |
| Local anaesthetic wound infiltration and abdominal nerves block during caesarean section for postoperative pain relief |
| Local anaesthetics applied during removal of the tonsils may not reduce pain following the operation |
| Local anaesthetics in cataract surgery: do eye drops work better with, or without, an injection of anaesthetic? |
| Local and regional anaesthesia at the time of surgery to prevent longer-term persistent pain after surgery |
| Local anesthetics for intrauterine device placement |
| Local antibiotics or antibiotics that target the whole body: which works better to treat chronic suppurative otitis media (persistent or recurring ear infection with discharge)? |
| Local consensus processes: effects on professional practice and health care outcomes |
| Local cooling for relieving pain from perineal trauma sustained during childbirth |
| Local corticosteroid injection compared to surgery for carpal tunnel syndrome |
| Local corticosteroid injection for carpal tunnel syndrome |
| Local corticosteroid injection for trigger finger |
| Local corticosteroid injection is effective in the short-term for the treatment of carpal tunnel syndrome |
| Local delivery antimicrobials for chronic periodontitis |
| Local nasal immunotherapy for allergic rhinitis |
| Local steroid injection for carpal tunnel syndrome |
| Local steroid injection for carpal tunnel syndrome |
| Local steroid injection for carpal tunnel syndrome |
| Local treatment of non-muscle-invasive bladder cancer with Bacillus Calmette-Guérin with or without interferon-alpha |
| Local treatment with Bacillus Calmette-Guérin following surgery for superficial bladder cancer reduces the risk of the cancer returning. |
| Local versus general anaesthesia for adults undergoing vitrectomy surgery |
| Local versus general anaesthesia for nasal fracture manipulation and reduction in adults |
| Local warming therapy for treating chronic wounds |
| Local wound analgesia in infants undergoing thoracic or abdominal surgery |
| Locally applied haemostatic agents in the management of acute epistaxis (nosebleeds) |
| Location of rehabilitation services for the elderly |
| Long chain polyunsaturated fatty acid supplementation in infants born at term |
| Long chain polyunsaturated fatty acid supplements for mothers who breastfeed |
| Long term antibiotics taken at regular intervals by people with bronchiectasis |
| Long term proton pump inhibitor (PPI) use and incidence of gastric (pre) malignant lesions. |
| Long versus short course treatment with Metformin + Clomiphene Citrate for ovulation induction in women with PCOS |
| Long versus short inspiratory times in neonates receiving mechanical ventilation |
| Long-acting aripiprazole (depot) versus placebo for schizophrenia |
| Long-acting beta-agonists and long-acting muscarinic antagonists in a combined inhaler versus either agent alone or placebo for chronic obstructive pulmonary disease |
| Long-acting beta2-agonists as an inhaled corticosteroid-sparing agent for chronic asthma in adults and children |
| Long-acting beta2-agonists for bronchiectasis |
| Long-acting beta2-agonists for chronic asthma in adults and children where background therapy contains varied or no inhaled corticosteroid |
| Long-acting beta2-agonists for chronic obstructive pulmonary disease: serious adverse events |
| Long-acting beta2-agonists for people with COPD |
| Long-acting beta2-agonists for poorly reversible chronic obstructive pulmonary disease |
| Long-acting beta2-agonists versus placebo in addition to inhaled corticosteroids in children and adults with chronic asthma |
| Long-acting beta2-agonists versus theophylline for maintenance treatment of asthma |
| Long-acting FSH versus daily FSH for women undergoing assisted reproduction |
| Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: an overview and network meta-analysis |
| Long-acting inhaled treatment to open up the airways in cystic fibrosis |
| Long-acting preparation of risperidone for schizophrenia |
| Long-term antibiotics for preventing recurrent urinary tract infection in children |
| Long-term antithrombotic therapy for patients with atrial fibrillation and stable coronary artery disease |
| Long-term blood transfusions to prevent a stroke in people with sickle cell disease |
| Long-term drug pharmacotherapy for obesity and overweight |
| Long-term effects of radiotherapy for glioma treatment on brain functioning |
| Long-term glucocorticoids for rheumatoid arthritis |
| Long-term hormone therapy for perimenopausal and postmenopausal women |
| Long-term mono- or dual-combination empagliflozin treatment for adults with type 2 diabetes mellitus |
| Long-term non-pharmacological weight loss interventions for adults with prediabetes |
| Long-term non-pharmacological weight loss interventions for adults with type 2 diabetes mellitus |
| Long-term pituitary down-regulation before in vitro fertilisation (IVF) for women with endometriosis |
| Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis |
| Long-term prognosis of low language proficiency in children |
| Long-term treatment for depression in older people |
| Long-term treatment for people with persistent depression |
| Longchain polyunsaturated fatty acid supplementation in preterm infants |
| Looking after our volunteers |
| Looking back, looking forward: Cochrane’s Editor in Chief’s end of year editorial out today |
| Loop diuretics cause modest blood pressure lowering |
| Loop diuretics during blood transfusion for anemia in preterm infants |
| Loop diuretics for acute kidney injury in adults and children |
| Loop diuretics for patients receiving blood transfusions |
| Lorcaserin for overweight or obese adults |
| Losigamone add-on therapy for focal epilepsy |
| Lovastatin for lowering lipids |
| Low bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia |
| Low blood oxygen levels versus normal blood oxygen levels in ventilated severely ill people |
| Low cost versus other screening tests to detect cervical cancer or precancer in developing countries |
| Low dose cytarabine monotherapy for acute myeloid leukaemia |
| Low dose cytarabine monotherapy for myelodysplastic syndromes |
| Low dose naltrexone for treatment of active Crohn’s disease |
| Low dose tricyclic antidepressants (TCAs) for depression |
| Low dose versus high dose stavudine for treating people with HIV infection |
| Low doses of aspirin do help prevent pre-eclampsia, but there is little information about whether they are of benefit for treatment of established pre-eclampsia. |
| LOW FAT DIETS ARE NO BETTER THAN OTHER WEIGHT REDUCING DIETS IN ACHIEVING LONG-TERM WEIGHT LOSS |
| Low FODMAP diet for treatment of irritable bowel syndrome |
| Low glycaemic index diets for cardiovascular disease |
| Low glycaemic index, or low glycaemic load, diets for diabetes mellitus |
| Low level laser therapy (Classes III) for treating osteoarthritis |
| Low level laser therapy for low-back pain |
| Low level laser therapy for rheumatoid arthritis |
| Low level laser therapy for treating venous leg ulcers |
| Low levels of sugar to prevent cardiovascular disease |
| Low molecular weight heparin (LMWH) versus unfractionated heparin (UFH) for haemodialysis anticoagulation |
| Low molecular weight heparin for preventing blockage of blood vessels in replanted fingers or toes after amputation injuries |
| Low molecular weight heparin for prevention of venous thromboembolism in adults with lower-limb immobilization in an outpatient setting |
| Low molecular weight heparins reduce the number of heart attacks and cause fewer complications after an acute coronary syndrome compared to unfractionated heparin |
| Low oxygen concentrations for embryo culture in In vitro fertilisation |
| Low pressure pneumoperitoneum versus standard pressure pneumoperitoneum in laparoscopic cholecystectomy |
| Low protein diets for adults with diabetic kidney disease |
| Low protein diets for non-diabetic adults with chronic kidney disease |
| Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants |
| Low vision rehabilitation for better quality of life in visually impaired adults |
