High flow nasal cannula for respiratory support in term infants

To assess the safety and efficacy of high flow nasal cannula oxygen therapy for respiratory support in term infants. We will compare HFNC with other forms of non-invasive support including:

  • low flow nasal cannula oxygen
  • head box oxygen
  • nasal continuous positive airway pressure
  • non-invasive positive pressure ventilation
  • alternative forms of HFNC (such as non humidified or humidified)

Subgroup analysis will be undertaken to determine efficacy of HFNC in term infants with different underlying conditions. These conditions include congestive heart failure, pneumonia/pneumonitis (aspiration, bacterial, or viral)

This is a protocol.