Guaiac-based faecal occult blood tests versus faecal immunochemical tests for colorectal cancer screening in average-risk individuals

The primary objective of this review will be to compare diagnostic accuracy of gFOBT and FIT screening for detecting advanced colorectal neoplasia in average-risk individuals.

Not applicable

We will investigate the following sources of heterogeneity:

A. Heterogeneity related to characteristics of the study population (i.e. sex, age limits, ethnicity, selection of invitees (identified from general practitioner records or population registers), average-risk or high risk individuals, tumour stage distribution and tumour location. High-risk individuals are defined as all CRC patients; subjects with a personal history of adenoma; individuals scheduled for diagnostic colonoscopy because of hereditary CRC syndromes or a positive family history of CRC; symptomatic subjects with complaints suspicious for CRC such as rectal blood loss, changed bowel habits, or weight loss; and all patients with a history of inflammatory bowel disease.

B. Heterogeneity related to number of tests per screening round

C. Heterogeneity related to the cut-off value used for FIT or the number of positive spots used to refer a gFOBT screened person for colonoscopy.

D. Heterogeneity related to the first or successive screening round

This is a protocol.