This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:

To determine the diagnostic accuracy of tuberculosis loop-mediated isothermal amplification (TB-LAMP) for the detection of pulmonary tuberculosis in children with presumptive pulmonary tuberculosis.

To compare the diagnostic accuracy of TB-LAMP and Xpert MTB/RIF Ultra for the detection of pulmonary tuberculosis in children with presumptive pulmonary tuberculosis.

To compare the diagnostic accuracy of TB-LAMP and smear microscopy for detecting pulmonary tuberculosis in children when TB-LAMP is considered as a replacement test for smear microscopy.

To determine the diagnostic accuracy of TB-LAMP for the detection of pulmonary tuberculosis if used as an add-on test amongst sputum smear-negative children.

To investigate potential sources of heterogeneity in the diagnostic accuracy of TB-LAMP due to factors such as smear status, age, gender, HIV status, setting, and tuberculosis burden.