This is a protocol for a Cochrane Review (intervention). The objectives are as follows:

To assess the effects of telehealth-based parent-mediated interventions, for both children with ASD and their parents, compared with no treatment, wait-list control, treatment as usual, an alternative parent-mediated intervention not delivered by telehealth, or an alternative telehealth-based intervention not mediated by parents.

A secondary objective is to explore the potential moderators of treatment effect.