This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:
To determine the prognostic value of the Decipher gene assay in men with biopsy-confirmed clinically localized prostate cancer before and after receiving treatment.
This objective can be framed in two questions following the population, index prognostic factor, comparator prognostic factor(s), outcome, timing, and setting (PICOTS) format as illustrated in Table 1.
Table 1. Review question in PICOTS format
Men with newly diagnosed, biopsy-confirmed clinically localized prostate cancer
Men who have undergone radical prostatectomy for clinically localized prostate cancer
Index prognostic factor
Decipher gene assay
Existing clinical prediction models
Overall survival and prostate-cancer survival
The outcome is to be predicted at any point after diagnosis
Before primary, local treatment with curative intent
Following primary surgical treatment with curative intent
This is a protocol.