Prediction of disease specific and overall survival in men with prostate cancer using the Decipher assay

This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:

To determine the prognostic value of the Decipher gene assay in men with biopsy-confirmed clinically localized prostate cancer before and after receiving treatment.

This objective can be framed in two questions following the population, index prognostic factor, comparator prognostic factor(s), outcome, timing, and setting (PICOTS) format as illustrated in Table 1.

Table 1. Review question in PICOTS format


Before treatment

After treatment


Men with newly diagnosed, biopsy-confirmed clinically localized prostate cancer

Men who have undergone radical prostatectomy for clinically localized prostate cancer

Index prognostic factor

Decipher gene assay


Existing clinical prediction models


Overall survival and prostate-cancer survival


The outcome is to be predicted at any point after diagnosis


Before primary, local treatment with curative intent

Following primary surgical treatment with curative intent

This is a protocol.

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