Blood pressure lowering efficacy of clonidine for primary hypertension

Primary objectives

To assess the dose-related effect of clonidine as compared to placebo in patients with primary hypertension as well as in patients without primary hypertension (postmenopausal women with hot flashes; patients treated for opioid withdrawal; and patients treated for alcohol addiction) on:

  1. Systolic blood pressure
  2. Diastolic blood pressure
  3. Withdrawals due to adverse effects
Secondary objectives
  1. Heart rate
  2. Pulse pressure
  3. Blood pressure variability

This is a protocol.