Cochrane Clinical Answers

Cochrane Clinical Answers

Readable, clinically-focused, actionable answers to inform point-of-care decision-making for health professionals. 

Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically-focused entry point to rigorous research from Cochrane Reviews. They are designed to be actionable and to inform point-of-care decision-making. Each CCA contains a clinical question, a short answer, and data for the outcomes from the Cochrane Review deemed most relevant to practising healthcare professionals. The evidence is displayed in a user-friendly tabulated format that includes narratives, data, and links to graphics.

CCAs are available with a Cochrane Library subscription or national license.

The following CCAs will be free until 31 March 2020:

The following CCAs will be free until 30 April  2020:

The following CCAs are free as part of our Special Collection on the Coronavirus (COVID-19): evidence relevant to critical care:

Fluid and vasopressor therapy: Initial resuscitation for hypotension typically includes administration of intravenous fluids, followed by initiation of vasopressors when hypotension persists.

Respiratory support and mechanical ventilation: Patients with severe acute respiratory infection may require supplemental oxygen and mechanical ventilatory support.

Weaning mechanical ventilation: Reducing weaning time is desirable in minimizing potential complications from mechanical ventilation.

Managing hypoxaemia: Acute or chronic hypoxaemia is a common reason for admission to intensive care and for provision of mechanical ventilation. Various refinements of mechanical ventilation or adjuncts are employed to improve patient outcomes.

Pharmacological treatment: Although fluid resuscitation and ventilatory support are the mainstays of treatment for patients with SARI requiring critical care, various pharmacological interventions have been suggested, yet the benefits and harms remain uncertain.

Managing delirium: Delirium is defined as a disturbance in attention, awareness, and cognition, with reduced ability to direct, focus, sustain, and shift attention, and reduced orientation to the environment.

Nutrition in intensive care: Critically ill people are at increased risk of malnutrition. Acute and chronic illness, trauma and inflammation induce stress‐related catabolism, and drug‐induced adverse effects may reduce appetite or increase nausea and vomiting. In addition, patient management in the intensive care unit (ICU) may also interrupt feeding routines.

The following CCAs are free as part of our Special Collection on the Coronavirus (COVID-19): infection control and prevention measures

Get involved: The clinical answer is written either by a practicing clinician or by a CCA Editor, with the answer being peer-reviewed by a practicing clinician. If you would like to join the Clinical Answers authoring team, please contact the team at We are specifically looking for clinicians in the following areas: respiratory medicine; care of the elderly; cardiovascular medicine; pregnancy and childbirth; neurology - especially epilepsy; infectious disease; paediatrics; rheumatology; ENT; and urology.

Friday, March 6, 2020