First-line therapy for adults with advanced renal cell carcinoma: a systematic review and network meta-analysis

The primary objective of this systematic review with network meta-analysis is to evaluate and compare the benefits and harms of first-line therapies for adults with advanced renal cell carcinoma, and thereby produce a clinically relevant hierarchy of therapies.

The secondary objectives are to maintain the currency of the evidence and provide continuous updates by using a living systematic review approach, as well as to incorporate data available from CSR.

This is a protocol.