A perianal abscess produces severe pain at or near the back passage (anus) due to an infection with collection of pus (abscess). The treatment is an urgent operation to incise the skin near the anus and drain the pus which relieves the pain. Some patients with a perianal abscess have an associated tunnel called a fistula which connects the anus to the adjacent skin. A fistula can cause problems such as leakage (discharge) from the skin near the anus or may produce a recurrent abscess, and therefore usually requires a repeat operation for its treatment. For this reason it has been proposed that fistula treatment at the same time as drainage of a perianal abscess may be better for patients. This systematic review assesses randomised trials that have addressed the benefits and risks of combined treatment of perianal abscesses and fistulae. Six studies have been published on this topic. The analyses show that combined treatment reduces the risk of persistent abscess or fistula, or repeat surgery without a statistically significant increase in postoperative incontinence.
阅读完整摘要
The perianal abscess is a common surgical problem. A third of perianal abscesses may manifest a fistula-in-ano which increases the risk of abscess recurrence requiring repeat surgical drainage. Treating the fistula at the same time as incision and drainage of the abscess may reduce the likelihood of recurrent abscess and the need for repeat surgery. However, this could affect sphincter function in some patients who may not have later developed a fistula-in-ano.
研究目的
We aimed to review the available randomised controlled trial evidence comparing incision and drainage of perianal abscess with or without fistula treatment.
检索策略
Randomised trials were identified from MEDLINE, EMBASE, the Cochrane Library, and reference lists of published papers and reviews.
纳入排除标准
Trials comparing outcome after fistula surgery with drainage of perianal abscess compared with drainage alone were included in the review.
资料收集与分析
The primary outcomes were recurrent or persistent abscess/fistula which may require repeat surgery and short-term and long-term incontinence. Secondary outcomes were duration of hospitalisation, duration of wound healing, postoperative pain, quality of life scores. For dichotomous variables, relative risks and their confidence intervals were calculated.
主要结果
We identified six trials, involving 479 subjects, comparing incision and drainage of perianal abscess alone versus incision and drainage with fistula treatment. Metaanalysis showed a significant reduction in recurrence, persistent abscess/fistula or repeat surgery in favour of fistula surgery at the time of abscess incision and drainage (RR=0.13, 95% Confidence Interval of RR = 0.07-0.24). Transient manometric reduction in anal sphincter pressures, without clinical incontinence, may occur after treatment of low fistulae with abscess drainage. Incontinence at one year following drainage with fistula surgery was not statistically significant (pooled RR 3.06, 95% Confidence Interval 0.7-13.45) with heterogeneity demonstrable between the trials (Chi2 =5.39,df=3, p=0.14, I2 =44.4%).
作者结论
The published evidence shows fistula surgery with abscess drainage significantly reduces recurrence or persistence of abscess/fistula, or the need for repeat surgery. There was no statistically significant evidence of incontinence following fistula surgery with abscess drainage. This intervention may be recommended in carefully selected patients.
