Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia

This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:

Primary objective

  • To assess whether anticholinergic burden, as defined at the level of each individual scale, is a prognostic factor for further cognitive decline or neuropsychiatric disturbances in people with mild cognitive impairment (MCI) or dementia.

Secondary objective

  • To compare the prognostic validity of different anticholinergic burden scales.

  • To examine the effect of type of dementia and severity of dementia on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances.

  • To examine the effect of setting (care home versus non-care home) on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances.

  • To examine whether anticholinergic burden is a prognostic factor for other clinical outcomes in people with MCI or dementia

This is a protocol.