Background
Restless legs syndrome (RLS) is a common and distressing disease affecting 5% to 15% of the population. Many physicians are still unaware of the disease and do not recognize its symptoms. This disease can affect sleep significantly, impairing quality of life. There is a need for safe and effective treatment for RLS. Current treatments include dopamine agonists, anticonvulsants, and opioids.
Question
Are benzodiazepines effective and safe for people with RLS?
Methods
We searched the literature for studies in any language, published or not, that considered benzodiazepines for the treatment of RLS.
Results
No studies were included in the review.
Discussion
Benzodiazepines have been used for a long time in people with RLS, because these drugs help sleep initiation and maintenance. As there was no properly conducted systematic review on the effectiveness of benzodiazepines, we performed one on this topic.
Conclusion
This systematic review shows that there is no good data to support or refute the use of benzodiazepines to treat symptoms of RLS.
閱讀完整摘要
Restless legs syndrome (RLS) is a common disease affecting about 5% to 15% of the population. Symptoms of RLS can be severe in a minority of and can have a major impact on sleep, mostly sleep initiation, and quality of life. Benzodiazepines are drugs that can induce and maintain sleep and, hence, intuitively are thought to be beneficial to people with RLS. Altough benzodiazepines, particularly clonazepam, are used to treat RLS symptoms, a systematic review done by the American Academy of Sleep Medicine stated that benzodiazepines should not be used as a first-line treatment, although could be used as a coadjuvant therapy.
目的
To evaluate the efficacy and safety of benzodiazepine compared to placebo or other treatment for idiopathic RLS, including unconfounded trials comparing benzodiazepines versus open control.
搜尋策略
In March 2016 we searched CENTRAL, MEDLINE, Embase and LILACS We checked the references of each study and contacted study authors to identify any additional studies. We considered studies published in any language.
選擇標準
Randomised clinical trials of benzodiazepine treatment in idiopathic RLS.
資料收集與分析
We did not perform data collection and analysis, since we did not include any studies,
主要結果
We did not identify any studies that met the inclusion criteria of the review. Two cross-over studies are awaiting classification because the cross-over trials did not give data at the end of the first cross-over period.
作者結論
The effectiveness of benzodiazepines for RLS treatment is currently unknown.
