Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma

To estimate the sensitivity and specificity of each technique for determining 1p/19q codeletion status in glioma, with a view to determining the most sensitive and specific technique(s).

If sufficient studies are identified, we aim to break down each technique by relevant features, for example the region analysed/probes used and the cut-off used to classify 1p/19q status.

To critically appraise and summarise current evidence on the resource use, costs and cost-effectiveness of techniques for determining 1p/19q status in gliomas (conduct a full integrated review of economic evidence) and assess the cost-effectiveness of the different approaches of determining 1p/19q status using a decision model.

This is a protocol.