Addenbrooke’s Cognitive Examination III (ACE-III) and mini-ACE for the detection of dementia and mild cognitive impairment

To assess the diagnostic test accuracy of the Addenbrooke’s Cognitive Examination-III (ACE-III) and the mini-ACE, for the screening of all-cause dementia, dementia subtypes (Alzheimer’s disease, vascular dementia, frontotemporal dementia, Lewy body dementia), and mild cognitive impairment, across all healthcare settings at all prespecified thresholds.

1) To identify the quality and quantity of the research evidence on the diagnostic test accuracy of the ACE-III and mini-ACE for the assessment of all-cause dementia, dementia subtypes (Alzheimer’s disease, vascular dementia, frontotemporal dementia, Lewy body dementia), and mild cognitive impairment, across all healthcare settings at all reported thresholds.

2) To identify sources of heterogeneity (age, sex, education, severity or stage of the target condition, operator characteristic of the index test and reference standard) in the included studies.

3) To identify gaps in the evidence where further research is required.

This is a protocol.

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