Computerised cognitive training for maintaining cognitive function in cognitively healthy people in late life


The terms 'cognition' and 'cognitive function' describe all of the mental activities related to thinking, learning, remembering, and communicating. Normal changes in cognition occur with ageing. There are also diseases that affect cognition, principally dementia, which becomes increasingly common with increasing age from about 65 years onwards. It is known that being mentally active throughout life is associated with lower risk of dementia. Therefore, it has been suggested that encouraging mental activity might be an effective way of maintaining good cognitive function as people age. Cognitive training comprises a set of standardised tasks intended to 'exercise the brain' in various ways. Programmes of cognitive training are often delivered by computers or mobile technology, so that people can do this training on their own at home. Increasingly, these are available as commercial packages that are advertised to the general public. We wanted to know whether long-term use of computerised cognitive training (CCT) is an effective way for people aged 65 and older to maintain good cognitive function as they age.

What we did

We searched the medical literature up to 15 March 2018 for trials that compared cognitive function of people aged 65 or older who had taken part in computerised cognitive training for a minimum of 12 weeks with cognitive function of a control group that had not done so. All participants should have been cognitively healthy at the start of the trials. For the comparison to be as fair as possible, it should have been decided randomly whether participants were in the cognitive training group or in the control group. We were primarily interested in overall measures of cognition. The choice of three months for the intervention was somewhat arbitrary, but we thought very short interventions were unlikely to have lasting effects, and we were interested in interventions that could be sustained over time.

What we found

We found eight trials with a total of 1183 participants to include in the review. Five trials provided CCT for three months, two for four months, and one for six months. We compared CCT with other activities, such as watching educational videos, and with no activity. We looked for effects on overall cognitive function and on specific cognitive functions, such as memory and thinking speed. All of the included studies had some design problems, which could have biased the results. Overall, we thought the quality of the evidence that we found was low or very low. This means we cannot be confident in the results, and that future research might well find something different. CCT may slightly improve overall cognitive function after 12 weeks of training; however, we found no evidence of a persistent effect 12 months after the intervention. We were unable to comment or found little evidence that CCT when compared with other activities may have a relevant effect on most of the specific cognitive functions that we examined. The longest trial found that compared to doing nothing, completing six months of CCT may have had a beneficial effect on memory. None of the included trials reported effects of cognitive training on quality of life or on daily activities, and none reported harmful effects of training.

Our conclusions

Compared to other activities, CCT may lead to slightly better overall cognitive function at the end of 12 weeks of training, but we found no evidence that the effect persists a year later. Compared to doing nothing, CCT may slightly improve memory at the end of six months of training. Although we excluded trials with less than 12 weeks of training, the trials that we included were still quite short for examining long-term effects as people age. A limitation of our review is that we did not include some trials with shorter training periods that did look for long-lasting effects, so it is possible that we missed some useful evidence. Many published studies have looked at computer training. Making sense of this substantial literature is difficult. It may be more helpful in the future to categorise trials by the duration of effects of training rather than by the duration of the training itself.

Authors' conclusions: 

We found low-quality evidence suggesting that immediately after completion of the intervention, small benefits of CCT may be seen for global cognitive function when compared with active controls, and for episodic memory when compared with an inactive control. These benefits are of uncertain clinical importance. We found no evidence that the effect on global cognitive function persisted 12 months later. Our confidence in the results was low, reflecting the overall quality of the evidence. In five of the eight trials, the duration of the intervention was just three months. The possibility that more extensive training could yield larger benefit remains to be more fully explored.

We found substantial literature on cognitive training, and collating all available scientific information posed problems. Duration of treatment may not be the best way to categorise interventions for inclusion. As the primary interest of older people and of guideline writers and policymakers involves sustained cognitive benefit, an alternative would be to categorise by length of follow-up after selecting studies that assess longer-term effects.

Read the full abstract...

Increasing age is associated with a natural decline in cognitive function and is the greatest risk factor for dementia. Cognitive decline and dementia are significant threats to independence and quality of life in older adults. Therefore, identifying interventions that help to maintain cognitive function in older adults or that reduce the risk of dementia is a research priority. Cognitive training uses repeated practice on standardised exercises targeting one or more cognitive domains and may be intended to improve or maintain optimal cognitive function. This review examines the effects of computerised cognitive training interventions lasting at least 12 weeks on the cognitive function of healthy adults aged 65 or older and has formed part of a wider project about modifying lifestyle to maintain cognitive function. We chose a minimum 12 weeks duration as a trade-off between adequate exposure to a sustainable intervention and feasibility in a trial setting.


To evaluate the effects of computerised cognitive training interventions lasting at least 12 weeks on cognitive function in cognitively healthy people in late life.

Search strategy: 

We searched to 31 March 2018 in ALOIS (, and we performed additional searches of MEDLINE, Embase, PsycINFO, CINAHL,, and the WHO Portal/ICTRP (, to ensure that the search was as comprehensive and as up-to-date as possible to identify published, unpublished, and ongoing trials.

Selection criteria: 

We included randomised controlled trials (RCTs) and quasi-RCTs, published or unpublished, reported in any language. Participants were cognitively healthy people, and at least 80% of the study population had to be aged 65 or older. Experimental interventions adhered to the following criteria: intervention was any form of interactive computerised cognitive intervention - including computer exercises, computer games, mobile devices, gaming console, and virtual reality - that involved repeated practice on standardised exercises of specified cognitive domain(s) for the purpose of enhancing cognitive function; the duration of the intervention was at least 12 weeks; cognitive outcomes were measured; and cognitive training interventions were compared with active or inactive control interventions.

Data collection and analysis: 

We performed preliminary screening of search results using a 'crowdsourcing' method to identify RCTs. At least two review authors working independently screened the remaining citations against inclusion criteria. At least two review authors also independently extracted data and assessed the risk of bias of included RCTs. Where appropriate, we synthesised data in random-effects meta-analyses, comparing computerised cognitive training (CCT) separately with active and inactive controls. We expressed treatment effects as standardised mean differences (SMDs) with 95% confidence intervals (CIs). We used GRADE methods to describe the overall quality of the evidence for each outcome.

Main results: 

We identified eight RCTs with a total of 1183 participants. The duration of the interventions ranged from 12 to 26 weeks; in five trials, the duration of intervention was 12 or 13 weeks. The included studies had moderate risk of bias, and the overall quality of evidence was low or very low for all outcomes.

We compared CCT first against active control interventions, such as watching educational videos. Negative SMDs favour CCT over control. Trial results suggest slight improvement in global cognitive function at the end of the intervention period (12 weeks) (standardised mean difference (SMD) -0.31, 95% confidence interval (CI) -0.57 to -0.05; 232 participants; 2 studies; low-quality evidence). One of these trials also assessed global cognitive function 12 months after the end of the intervention; this trial provided no clear evidence of a persistent effect (SMD -0.21, 95% CI -0.66 to 0.24; 77 participants; 1 study; low-quality evidence). CCT may result in little or no difference at the end of the intervention period in episodic memory (12 to 17 weeks) (SMD 0.06, 95% CI -0.14 to 0.26; 439 participants; 4 studies; low-quality evidence) or working memory (12 to 16 weeks) (SMD -0.17, 95% CI -0.36 to 0.02; 392 participants; 3 studies; low-quality evidence). Because of the very low quality of the evidence, we are very uncertain about the effects of CCT on speed of processing and executive function.

We also compared CCT to inactive control (no interventions). We found no data on our primary outcome of global cognitive function. At the end of the intervention, CCT may lead to slight improvement in episodic memory (6 months) (mean difference (MD) in Rivermead Behavioural Memory Test (RBMT) -0.90 points, 95% confidence interval (CI) -1.73 to -0.07; 150 participants; 1 study; low-quality evidence) but can have little or no effect on executive function (12 weeks to 6 months) (SMD -0.08, 95% CI -0.31 to 0.15; 292 participants; 2 studies; low-quality evidence), working memory (16 weeks) (MD -0.08, 95% CI -0.43 to 0.27; 60 participants; 1 study; low-quality evidence), or verbal fluency (6 months) (MD -0.11, 95% CI -1.58 to 1.36; 150 participants; 1 study; low-quality evidence). We could not determine any effects on speed of processing because the evidence was of very low quality.

We found no evidence on quality of life, activities of daily living, or adverse effects in either comparison.