| Intracervical prostaglandins for induction of labour |
| Intracystic bleomycin for children with cystic craniopharyngiomas |
| Intracytoplasmic sperm injection versus conventional techniques for oocyte insemination during in vitro fertilisation in couples with non-male subfertility |
| Intragastric balloon for obesity |
| Intrahepatic shunts in adults with kidney failure due to liver disease |
| Intramedullary nailing for femoral shaft fractures in adults |
| Intramedullary nailing treat tibial shaft fractures in adults |
| Intramedullary nails for extracapsular hip fractures in adults |
| Intramuscular and intravenous opioid pain relieving drugs in labour |
| Intramuscular arteether to treat severe malaria |
| Intramuscular penicillin for the prevention of early onset group B streptococcal infection in newborn infants |
| Intramuscular versus intravenous anti-D for preventing Rhesus alloimmunization during pregnancy |
| Intramuscular versus oral corticosteroids for acute asthma |
| Intranasal corticosteroids for asthma control in people with coexisting asthma and rhinitis |
| Intranasal corticosteroids for non-allergic rhinitis |
| Intranasal fentanyl for the treatment of children in acute pain |
| Intranasal oxytocin for autism spectrum disorders (ASD) |
| Intranasal phototherapy for allergic rhinitis |
| Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis |
| Intraoperative fluid irrigation for traumatic wounds |
| Intraoperative neuromonitoring for the prevention of iatrogenic injury during cervical and thoracic spine surgery |
| Intraoperative sub-areolar frozen section analysis for detecting nipple involvement in candidates for nipple-sparing mastectomy |
| Intraoperative ventilation strategies for obese patients undergoing bariatric surgery |
| Intrapartum antibiotics for Group B streptococcal colonisation |
| Intrapartum antibiotics for known maternal Group B streptococcal colonization |
| Intrapartum interventions for preventing shoulder dystocia |
| Intraperitoneal chemotherapy (administered into the peritoneal cavity) for advanced ovarian cancer improves both overall and disease-free survival |
| Intraperitoneal chemotherapy for gastric carcinoma |
| Intraperitoneal chemotherapy for primary gastric cancer |
| Intrarectal quinine versus intravenous or intramuscular quinine for treating Plasmodium falciparum malaria |
| Intrastromal corneal ring segments for keratoconus |
| Intrathecal baclofen for treating spasticity in children with cerebral palsy |
| Intratracheal Clara cell secretory protein (CCSP) administration in preterm infants with or at risk of respiratory distress syndrome |
| Intratracheal instillation of corticosteroids using surfactant as a vehicle for the prevention of chronic lung disease in preterm infants with respiratory distress syndrome |
| Intratympanic gentamicin for Ménière's disease or syndrome |
| Intratympanic steroids for Ménière's disease or syndrome |
| Intrauterine contraception soon after childbirth |
| Intrauterine devices for contraception in nulliparous women |
| Intrauterine insemination versus fallopian tube sperm perfusion for non-tubal infertility |
| Intrauterine insemination versus intracervical insemination in donor sperm treatment |
| Intrauterine progesterone-releasing system for treatment of endometrial hyperplasia |
| Intravascular brachytherapy (radiation treatment), inside arteries or bypass grafts, after angioplasty or stent surgery |
| Intravascular low-level helium-neon laser irradiation on blood for acute ischemic stroke |
| Intravenous alpha-1 antitrypsin augmentation therapy for treating patients with alpha-1 antitrypsin deficiency and lung disease |
| Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators |
| Intravenous antibiotics can be delivered through a variety of devices |
| Intravenous antibiotics given at home for people with cystic fibrosis |
| Intravenous beta2-agonists and intravenous aminophylline for acute asthma |
| Intravenous beta2-agonists for acute asthma in the emergency department |
| Intravenous chemotherapy versus intra-arterial chemotherapy for retinoblastoma |
| Intravenous dexamethasone for extubation of newborn infants |
| Intravenous fluid therapy for management of acute infections |
| Intravenous fluids compared to nasogastric or orogastric tube hydration for children hospitalised with bronchiolitis |
| Intravenous fluids for body fluid management during abdominal aortic surgery |
| Intravenous fluids for preventing prolonged labour in women giving birth to their first baby |
| Intravenous heparin during ruptured abdominal aortic aneurysmal repair |
| Intravenous hyoscine-N-butyl bromide for aiding colonoscopy |
| Intravenous immunoglobulin for Alzheimer's disease |
| Intravenous immunoglobulin for Guillain-Barré syndrome |
| Intravenous immunoglobulin for juvenile idiopathic arthritis |
| Intravenous immunoglobulin for multifocal motor neuropathy |
| Intravenous immunoglobulin for myasthenia gravis |
| Intravenous immunoglobulin for presumed viral myocarditis in children and adults |
| Intravenous immunoglobulin for preventing infection in preterm and/or low birth weight infants |
| Intravenous immunoglobulin for suspected or proven infection in neonates |
| Intravenous immunoglobulin for the treatment of Kawasaki disease in children |
| Intravenous immunoglobulin in addition to standard treatments for Wegener's granulomatosis |
| Intravenous immunoglobulin to prevent relapses during pregnancy and postpartum in multiple sclerosis |
| Intravenous immunoglobulins for epilepsy |
| Intravenous immunoglobulins for the treatment of infections in patients with haematological cancers |
| Intravenous immunoglobulins for treating patients with severe sepsis and septic shock |
| Intravenous in-line filters for preventing morbidity and mortality in neonates |
| Intravenous infusion of lidocaine starting at the time of surgery for reduction of pain and improvement of recovery after surgery |
| Intravenous iron for the treatment of non-anaemic iron deficiency in adults |
| Intravenous magnesium for acute myocardial infarction |
| Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit |
| Intravenous N-acetylcysteine compared to placebo for treatment of systemic inflammatory response syndrome and sepsis in seriously ill adults |
| Intravenous naftidrofuryl for treating critical limb ischaemia |
| Intravenous or enteral loop diuretics for preterm infants with (or developing) chronic lung disease |
| Intravenous or inhalational anaesthesia for abdominal surgery assisted by a computerized surgical robot |
| Intravenous paracetamol (acetaminophen) for pain after surgery in adults and children |
| Intravenous plasma expanders for preventing ovarian hyperstimulation syndrome (OHSS) |
| Intravenous prostaglandin for induction of labour |
| Intravenous secretin for autism spectrum disorders (ASD) |
| Intravenous versus inhalation anaesthesia for one-lung ventilation |
| Intravenous versus inhalation anaesthesia for patients undergoing on-pump or off-pump coronary artery bypass grafting |
| Intravenous versus inhaled anaesthesia for children having day surgery procedures |
| Intravenous zoledronate for postmenopausal osteoporosis |
| Intraventricular antibiotics for bacterial meningitis in neonates |
| Intraventricular streptokinase after intraventricular hemorrhage in newborn infants |
| Intravesical Bacillus Calmette-Guérin versus epirubicin for Ta and T1 bladder cancer |
| Intravesical doxorubicin versus epirubicin for superficial bladder cancer |
| Intravesical gemcitabine for non-muscle invasive bladder cancer |
| Intravesical therapy for non-muscle invasive bladder cancer: a network meta-analysis |
| Intravesical treatments for painful bladder syndrome/interstitial cystitis(PBS/IC). |
| Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy after retinal reattachment surgery |
| Introducing Cochrane Global Ageing |
| Introducing Cochrane Heart, Stroke and Circulation |
| Introducing Cochrane People, Health Systems and Public Health |
| Introducing Karla Soares-Weiser, Editor in Chief of the Cochrane Library |
| Introducing salt solution into the womb (amnioinfusion) to reduce complications associated with pregnancy fluid and sac infection (chorioamnionitis) |
| Introducing the Cochrane Thai translation project |
| Introducing the new Cochrane Handbook for Diagnostic Test Accuracy |
| Intubation methods for obese patients requiring general anaesthesia |
| Invasive management for patent ductus arteriosus in preterm infants |
| Invasive urodynamic studies for the management of lower urinary tract symptoms (LUTS) in men with voiding dysfunction |
| Invasive versus non-invasive ventilation for acute respiratory failure in neuromuscular disease and chest wall disorders |
| Inverted T versus vertical scar incision technique for women undergoing breast reduction surgery |
| Investing in the world's future researchers - Covidence Scholarship and Selection Panel |
| Invitation to stand for election to the Governing Board |
| Involving adults who use mental health services as providers of mental health services to others |
| Involving service users as researchers for the evaluation of adult statutory mental health services |
| Involving service users as trainers for professionals working in adult statutory mental health services |
| Iodine supplementation for preventing iodine deficiency disorders in children |
| Iodine supplementation for preventing iodine deficiency disorders in children and adolescents |
| Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants |
| Iodine supplementation for women before, during or after pregnancy |
| Iodine-131-meta-iodobenzylguanidine therapy for patients with newly diagnosed high-risk neuroblastoma |
| Iodised salt for preventing iodine deficiency disorders |
| Ionisers for chronic asthma |
| Ipratropium bromide for stable chronic obstructive pulmonary disease |
| Ipratropium bromide versus long-acting beta-2 agonists for stable chronic obstructive pulmonary disease |
| Ipratropium bromide versus short acting beta-2 agonists for stable chronic obstructive pulmonary disease |
| IR methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults |
| Iridectomy or iridotomy for preventing angle-closure glaucoma |
| Iridotomy to slow progression of visual field loss in angle-closure glaucoma |
| Irinotecan chemotherapy combined with fluoropyrimidines versus irinotecan alone for overall survival and progression-free survival in patients with advanced and/or metastatic colorectal cancer |
| Iron and folate supplementation in pregnancy |
| Iron for the treatment of restless legs syndrome |
| Iron nutriture for colorectal cancer |
| Iron supplementation for iron deficiency anemia in children |
| Iron supplementation for sickle cell disease during pregnancy |
| Iron supplementation for the treatment of breath-holding attacks in children |
| Iron supplementation in pregnancy |
| Iron supplementation taken daily for improving health in menstruating women |
| Iron supplements for children living in malaria-endemic countries |
| Iron supplements taken one, two or three times a week for preventing anaemia, and its consequences in menstruating women |
| Iron therapy for improving physical and intellectual development in children under the age of three who are anaemic due to a lack of iron |
| Iron treatment for adults and children with reduced kidney function |
| Iron treatment for low red blood cell count prior to surgery |
| Iron treatment in adults without kidney disease |
| Iron-chelating agents for treating malaria |
| Irrigating solutions for use in root canal treatment of teeth |
| Is a 'quick diagnosis' test on an ovarian mass during surgery accurate? |
| Is adding an anti-leukotriene to an inhaled corticosteroid better than using an inhaled corticosteroid alone for persistent asthma? |
| Is adding an anti-leukotriene to an inhaled corticosteroid better than using an inhaled corticosteroid alone in children with persistent asthma? |
| Is adding focused radiation (radiosurgery) to whole brain radiation therapy beneficial to people with brain metastases? |
| Is alpha-lipoic acid (a natural antioxidant) better than no treatment or dummy treatment for nerve damage in people with diabetes? |
| Is alpha-lipoic acid (a natural antioxidant) better than no treatment or dummy treatment for nerve damage in people with diabetes? |
| Is antibiotic prophylaxis effective or safe for women undergoing operative vaginal delivery? |
| Is attachment of the excretory duct of the pancreas to the second part of the small intestine better than other reconstruction methods to reduce leakage of juice from the pancreas to the abdominal tissues? |
| Is bed sharing an effective and safe method in the care of healthy term neonates? |
| Is breathing retraining useful in the treatment of children with dysfunctional breathing/hyperventilation syndrome? |
| Is carvedilol more effective or safer than traditional, non-selective beta-blockers for people with cirrhosis and gastroesophageal varices? |
| Is changing dietary fat intake beneficial or harmful for people with gallstones? |
| Is chemotherapy beneficial to patients with brain metastases from small cell lung cancer? |
| Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus? |
| Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus? |
| Is Cognitive behavioural therapy as effective as other psychosocial treatments for people with schizophrenia |
| Is Cognitive behavioural therapy as effective as standard care for people with schizophrenia |
| Is colchicine an effective treatment for people with COVID-19? |
| Is continuous positive airway pressure (CPAP) during the postoperative period useful? |
| Is continuous renal replacement therapy beneficial for people with rhabdomyolysis? |
| Is Cyclamen europaeum extract effective for people with acute sinusitis? |
| Is D-cycloserine effective and safe for social and communication skills deficits in people with ASD? |
| Is dance movement therapy an effective intervention for dementia? |
| Is dance movement therapy an effective intervention for dementia? A review of the evidence |
| Is dance movement therapy an effective treatment for depression? A review of the evidence |
| Is dexmedetomidine a good option for patients undergoing awake fibreoptic intubation? |
| Is e-learning more effective than traditional learning for health professionals? |
| Is early or late tracheostomy more effective in critically ill COVID-19 patients who are expected to require long-term artificial ventilation? |
| Is electrical stimulation effective for treating pressure ulcers? |
| Is endometrial resection or ablation more effective, safer or more acceptable than different routes of hysterectomy? |
| Is evacuation proctogram still the reference standard for diagnosis of posterior pelvic floor disorders in women with obstructed defaecation syndrome? |
| Is extending the treatment time by specialist mental health teams better for people with recent-onset psychosis? |
| Is face-down positioning better than other positioning after vitrectomy and gas tamponade for macula-involving rhegmatogenous retinal detachments? |
| Is favipiravir useful in treating people with COVID‐19? |
| Is fenofibrate effective for diabetic retinopathy? |
| Is general anesthesia or loco-regional anesthesia better for people needing an endovascular repair of an aortic aneurysm? |
| Is giving breathing support through the nose effective in babies that need help breathing at birth? |
| Is home haemodialysis better than in-centre haemodialysis for people with kidney failure? |
| Is home or hospital treatment better for people with blood clots in the lungs? |
| Is inhaled magnesium sulfate a safe and effective treatment for people with asthma attacks? |
| Is intravenous immunoglobulin safe and effective for people with chronic inflammatory demyelinating polyradiculoneuropathy? |
| Is it better for a baby to be born immediately or to wait for labour to start spontaneously when waters break at or after 37 weeks? |
| Is it better for the baby to be born immediately or wait for labour to start if the waters break without contractions before 37 weeks of pregnancy? |
| Is it better to add long-acting muscarinic antagonists or long-acting beta2-agonists to inhaled corticosteroids for people with uncontrolled asthma? |
| Is it better to do strabismus (squint) surgery before or after completing amblyopia (lazy eye) treatment? |
| Is it better to insert an implant or intrauterine device (coil) for contraception within days of childbirth or wait 4 to 6 weeks? |
| Is it better to take blood pressure-lowering medicines in the morning or evening to treat high blood pressure? |
| Is it safe to use lower blood counts (haemoglobin levels) as a trigger for blood transfusion in order to give fewer blood transfusions? |
| Is it safe to use lower blood counts as a trigger for blood transfusion? |
| Is it safer to deliver a baby immediately or wait if the mother has high blood pressure after 34 weeks of pregnancy that is not persistently severe? |
| Is L-acetylcarnitine an effective treatment for fragile X syndrome? |
| Is limiting the amount of fluid given to adults during surgery as good as using haemodynamic monitoring, which continuously measures changes in blood pressure or speed of blood flow inside the arteries, to guide fluid administration? |
| Is LipiFlow more effective than other dry eye disease treatments? |
| Is local or general anaesthesia better during surgery to widen the main blood vessel to the brain when it becomes narrowed (carotid endarterectomy)? |
| Is local or major surgery better for treating early rectal cancer with or without additional treatments before or after surgery? |
| Is magnesium sulfate effective for chronic obstructive pulmonary disease (COPD) flare-ups? |
| Is magnesium sulphate for women at risk of preterm birth better than placebo for protecting their babies' brains? |
| Is magnetic seizure therapy an effective add-on treatment for people with treatment-resistant depression? |
| Is maintenance therapy following previous treatment better than observation or placebo for treating chronic lymphocytic leukaemia in adults? |
| Is measuring bilirubin levels through the skin a reliable alternative to measuring bilirubin levels in the blood of newborns? |
| Is metformin an effective treatment for adults with type 2 diabetes? |
| Is methylphenidate an effective treatment for children and adolescents with attention deficit hyperactivity disorder (ADHD) and does it cause unwanted effects? |
| Is methylphenidate an effective treatment for children and adolescents with attention deficit hyperactivity disorder (ADHD) and does it cause unwanted effects? |
| Is once-daily ICS/LABA combined in one inhaler more beneficial than inhaled LAMA for treatment of people with COPD? |
| Is plasma from the blood of people who have recovered from COVID-19 an effective treatment for other people with COVID-19? |
| Is prostate MRI, with or without MRI-targeted biopsy, better than systematic biopsy for detecting prostate cancer in men? |
| Is recent-onset psychosis best treated by a specialist mental health team? |
| Is routine veno-venous bypass necessary in liver transplantation? |
| Is shock wave treatment better than surgical procedures for removing kidney stones? |
| Is shock wave treatment better than surgical procedures for removing kidney stones? |
| Is siponimod an effective treatment for multiple sclerosis (MS) and does it cause unwanted effects? |
| Is skin puncture better than exposing the femoral artery for minimally invasive repairs of abdominal aortic aneurysms? |
| Is skin-sparing mastectomy an effective and safe surgical procedure for the treatment of breast cancer? |
| Is sodium bicarbonate therapy helpful for people with acute kidney problems? |
| Is stretch effective for treating and preventing joint deformities? |
| Is supervised maintenance after pulmonary rehabilitation effective compared to usual treatment in people with chronic obstructive pulmonary disease? |
| Is supplemental nutrition before surgery better than a regular diet for people having surgery on the digestive system? |
| Is surgery or observation better for people who have a severe blunt injury to the liver? |
| Is surgery with a high-pressure water jet (hydrosurgery) better than conventional surgery for early treatment of mid-depth burns? |
| Is taking an immunostimulant on top of standard medications beneficial for people with chronic obstructive pulmonary disease, chronic bronchitis, or both? |
| Is taking inhaled corticosteroids only when asthma symptoms get worse as safe and effective as taking inhaled corticosteroids every day? |
| Is the blood pressure lowering effect of dihydropyridine calcium channel blockers consistent or variable throughout 24 hours? |
| Is the blood pressure-lowering effect of beta-blockers with partial agonist activity consistent or variable throughout the day? |
| Is the combination of nirmatrelvir plus ritonavir effective for treating or preventing COVID-19? |
| Is the McKenzie method effective for the treatment of (sub)acute non-specific low back pain? |
| Is the outcome of severe postoperative eye infection improved by early surgery to remove the vitreous gel? |
| Is the use of a constricting device (tourniquet) during amputation safe and effective in reducing complications? |
| Is the use of antibiotics beneficial for treating leptospirosis? |
| Is the use of fluoride toothpaste during early childhood associated with discolouration/mottling of teeth? |
| Is the workplace an effective setting for helping people to stop smoking |
| Is there a benefit of implanting a mobile disc prosthesis over traditional fusion surgery for treatment of a herniated disc in the neck? |
| Is there a best way to remove dead tissue from surgical wounds? |
| Is there a difference between pars plana vitrectomy with internal limiting membrane flap and pars plana vitrectomy with internal limiting membrane peeling for large macular holes? |
| Is there an increased risk of ovarian cancer in women treated with drugs for subfertility? |
| Is three-dimensional saline infusion sonography (3D SIS) better than two-dimensional (2D) SIS for detecting polyps and fibroids? |
| Is treatment with corticosteroids beneficial and safe for people with pneumonia? |
| Is ultrasound guidance a good option for peripheral intravenous cannulation in adults? |
| Is ultrasound guidance a good option for peripheral intravenous cannulation in adults? |
| Is urgent-start peritoneal dialysis safe for patients with chronic kidney disease? |
| Is vitamin D an effective and safe addition to antibiotics for treating children with acute pneumonia? |
| Is vitamin D an effective and safe treatment for COVID-19? |
| Is vitamin D supplementation beneficial or harmful for women during pregnancy? |
| Is voriconazole better than amphotericin B or fluconazole to prevent and treat fungal infections in cancer patients with poor immune defence systems |
| Is water fluoridation effective in preventing tooth decay? |
| Is water-based exercise an effective and safe type of exercise for adults with asthma? |
| Is withdrawal of drug therapy feasible in patients with CD who have achieved remission? |
| Is X-ray treatment (radiotherapy) after removal of breast tissue (mastectomy) better than no X-ray treatment in women diagnosed with breast cancer that has spread to one to three armpit lymph nodes? |
