Low birth weight babies have a higher chance or survival if they are kept warm. The right conditions can be made by placing the baby in an incubator. The air can be heated to a desired temperature, or radiant heat lamps inside the incubator can adjust to the baby’s body temperature (servo-control). The review of trials found that keeping a baby’s skin temperature at 36C degrees by servo-control reduces the newborn death rate in low birth weight babies rather than setting a constant incubator temperature of 31.8C. More research is needed.
阅读完整摘要
Randomized trials have shown that the neonatal mortality rate of low birth-weight babies can be reduced by keeping them warm. For low birth-weight babies nursed in incubators, warm conditions may be achieved either by heating the air to a desired temperature, or by servo-controlling the baby's body temperature at a desired set-point.
研究目的
In low birth weight infants, to determine the effect on death and other important clinical outcomes of targeting body temperature rather than air temperature as the end-point of control of incubator heating.
检索策略
Standard search strategy of the Cochrane Neonatal Review Group. Searches were made of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 3, 2004) and MEDLINE, 1966 to April 2008.
纳入排除标准
Randomized or quasi-randomized trials which test the effects of having the heat output of the incubator servo-controlled from body temperature compared with setting a constant incubator air temperature.
资料收集与分析
Trial methodologic quality was systematically assessed. Outcome measures included death, timing of death, cause of death, and other clinical outcomes. Categorical outcomes were analyzed using relative risk and risk difference. Meta-analysis assumed a fixed effect model.
主要结果
Two eligible trials were found. In total, they included 283 babies and 112 deaths. Compared to setting a constant incubator air temperature of 31.8C, servo-control of abdominal skin temperature at 36C reduces the neonatal death rate among low birth weight infants: relative risk 0.72 (95% CI 0.54, 0.97); risk difference -12.7% (95% CI -1.6, -23.9). This effect is even greater among VLBW infants.
作者结论
During at least the first week after birth, low birth weight babies should be provided with a carefully regulated thermal environment that is near the thermoneutral point. For LBW babies in incubators, this can be achieved by adjusting incubator temperature to maintain an anterior abdominal skin temperature of at least 36C, using either servo-control or frequent manual adjustment of incubator air temperature.
