Cochrane Handbook for Systematic Reviews of Interventions contains essential guidance for preparing and maintaining Cochrane Reviews of the effects of health interventions. GRADE approach is covered especially in the following chapters:

• Chapter 14: Completing ‘Summary of findings’ tables and grading the certainty of the evidence and
• Chapter 15: Interpreting results and drawing conclusions

Oher sections of the Cochrane Handbook addressing the GRADE approach:

• 11.5 Evaluating confidence in the results of a network meta-analysis
• 24.7.2 Evaluating the strength of evidence provided by reviews that include non-randomized studies