Oncoplastic breast-conserving surgery (O-BCS) for women with primary breast cancer

Background

Traditional surgery for early breast cancer is standard breast-conserving surgery (S-BCS) which aims to keep as much of the breast as possible. For women with large tumours compared to their breast size it can be difficult to conserve the breast whilst ensuring all the tumour is removed and may mean that mastectomy is needed. The most important part of surgical treatment for breast cancer is removing all cancer. In recent years, oncoplastic breast surgery techniques have been used to conserve the breast whilst removing breast cancer by applying the principles of plastic surgery, resulting in better cosmetic results. Oncoplastic breast-conserving surgery (O-BCS) may also result in better patient satisfaction and quality of life.

Traditionally, surgeons have either preserved the breast tissue by removing the cancerous lump (S-BCS) or reconstructing immediately after mastectomy. O-BCS involves removing cancer and either moving/adjusting the remaining breast tissue around (volume displacement) or bringing in tissue from elsewhere to fill the defect after breast cancer removal (volume replacement). There are many techniques that fall under O-BCS that we have listed in full in other parts of the review; however, all are similar in their principle.

Review question

We reviewed the evidence about the effects of O-BCS (that is, removing some of the breast tissue and then reconstructing the remaining breast by either mobilising the breast tissue (mammaplasty or volume displacement) or bringing the tissue from elsewhere (partial breast reconstruction or volume replacement)) compared to other S-BCS (that is, removing the tumour in the breast without the need for further breast adjustment) or mastectomy (that is, removing all the breast tissue with or without reconstruction). We studied the effect on cancer-related (local recurrence, disease-free survival and overall survival), quality of life and cosmetic outcomes in women with breast cancer.

Study characteristics

The evidence is current to August 2020. We included 78 studies involving 178,813 patients with breast cancer. We split the studies into those that compared O-BCS to S-BCS, O-BCS to mastectomy alone and O-BCS to mastectomy with reconstruction. Some studies contributed to more than one comparison.

Key results

It seemed that O-BCS resulted in similar rates of local recurrence (that is, whether cancer returned in the same breast) and disease-free survival (free of any breast cancer after initial treatment) when compared to S-BCS, and resulted in less need for a second re-excision surgery (which may be required if the tumour is not fully removed in the first operation). O-BCS may result in more complications and more biopsies in the years after the surgery compared to S-BCS. It seems that O-BCS may give better patient satisfaction and surgeon rating for the look of the breast, but the evidence for this is of poor quality, and due to lack of numerical data, it was not possible to pool the results of different studies.

It was not possible to conclude whether or not cancer outcomes of local recurrence and disease-free survival for O-BCS were similar to mastectomy with or without reconstruction as there were not many good-quality studies. It seems O-BCS has fewer complications than surgeries involving mastectomy.

In practice, the decision to select O-BCS should be done through shared decision making with the surgeon, discussing the potential risks and benefits.

Certainty of evidence

The certainty of the evidence in this review was very low. The studies had several methodological flaws. Differences between groups in cancer stage and other cancer treatments that were used may have affected the results. This is likely to have an impact on the findings, and future research is needed to investigate the topic further.

Authors' conclusions: 

The evidence is very uncertain regarding oncological outcomes following O-BCS compared to S-BCS, though O-BCS has not been shown to be inferior. O-BCS may result in less need for a second re-excision surgery but may result in more complications and a greater recall rate than S-BCS. It seems that O-BCS may give better patient satisfaction and surgeon rating for the look of the breast, but the evidence for this is of poor quality, and due to lack of numerical data, it was not possible to pool the results of different studies. It seems O-BCS results in fewer complications compared with surgeries involving mastectomy.

Based on this review, no certain conclusions can be made to help inform policymakers. The surgical decision for what operation to proceed with should be made jointly between clinician and patient after an appropriate discussion about the risks and benefits of O-BCS personalised to the patient, taking into account clinicopathological factors. This review highlighted the deficiency of well-conducted studies to evaluate efficacy, safety and patient-reported outcomes following O-BCS.

Read the full abstract...
Background: 

Oncoplastic breast-conserving surgery (O-BCS) involves removing the tumour in the breast and using plastic surgery techniques to reconstruct the breast. The adequacy of published evidence on the safety and efficacy of O-BCS for the treatment of breast cancer compared to other surgical options for breast cancer is still debatable. It is estimated that the local recurrence rate is similar to standard breast-conserving surgery (S-BCS) and also mastectomy, but the aesthetic and patient-reported outcomes may be improved with oncoplastic techniques.

Objectives: 

Our primary objective was to assess oncological control outcomes following O-BCS compared with other surgical options for women with breast cancer. Our secondary objective was to assess surgical complications, recall rates, need for further surgery to achieve adequate oncological resection, patient satisfaction through patient-reported outcomes, and cosmetic outcomes through objective measures or clinician-reported outcomes.

Search strategy: 

We searched the Cochrane Breast Cancer Group's Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL),
MEDLINE (via OVID), Embase (via OVID), the World Health Organization's International Clinical Trials Registry
Platform and ClinicalTrials.gov on 7 August 2020. We did not apply any language restrictions.

Selection criteria: 

We selected randomised controlled trials (RCTs) and non-randomised comparative studies (cohort and case-control studies). Studies evaluated any O-BCS technique, including volume displacement techniques and partial breast volume replacement techniques compared to any other surgical treatment (partial resection or mastectomy) for the treatment of breast cancer.

Data collection and analysis: 

Four review authors performed data extraction and resolved disagreements. We used ROBINS-I to assess the risk of bias by outcome. We performed descriptive data analysis and meta-analysis and evaluated the quality of the evidence using GRADE criteria. The outcomes included local recurrence, breast cancer-specific disease-free survival, re-excision rates, complications, recall rates, and patient-reported outcome measures.

Main results: 

We included 78 non-randomised cohort studies evaluating 178,813 women. Overall, we assessed the risk of bias per outcome as being at serious risk of bias due to confounding; where studies adjusted for confounding, we deemed these at moderate risk.

Comparison 1: oncoplastic breast-conserving surgery (O-BCS) versus standard-BCS (S-BCS)

The evidence in the review found that O-BCS when compared to S-BCS, may make little or no difference to local recurrence; either when measured as local recurrence-free survival (hazard ratio (HR) 0.90, 95% confidence interval (CI) 0.61 to 1.34; 4 studies, 7600 participants; very low-certainty evidence) or local recurrence rate (HR 1.33, 95% CI 0.96 to 1.83; 4 studies, 2433 participants; low-certainty evidence), but the evidence is very uncertain due to most studies not controlling for confounding clinicopathological factors. O-BCS compared to S-BCS may make little to no difference to disease-free survival (HR 1.06, 95% CI 0.89 to 1.26; 7 studies, 5532 participants; low-certainty evidence). O-BCS may reduce the rate of re-excisions needed for oncological resection (risk ratio (RR) 0.76, 95% CI 0.69 to 0.85; 38 studies, 13,341 participants; very low-certainty evidence), but the evidence is very uncertain. O-BCS may increase the number of women who have at least one complication (RR 1.19, 95% CI 1.10 to 1.27; 20 studies, 118,005 participants; very low-certainty evidence) and increase the recall to biopsy rate (RR 2.39, 95% CI 1.67 to 3.42; 6 studies, 715 participants; low-certainty evidence). Meta-analysis was not possible when assessing patient-reported outcomes or cosmetic evaluation; in general, O-BCS reported a similar or more favourable result, however, the evidence is very uncertain due to risk of bias in the measurement methods.

Comparison 2: oncoplastic breast-conserving surgery (O-BCS) versus mastectomy alone

O-BCS may increase local recurrence-free survival compared to mastectomy but the evidence is very uncertain (HR 0.55, 95% CI 0.34 to 0.91; 2 studies, 4713 participants; very low-certainty evidence). The evidence is very uncertain about the effect of O-BCS on disease-free survival as there were only data from one study. O-BCS may reduce complications compared to mastectomy, but the evidence is very uncertain due to high risk of bias mainly resulting from confounding (RR 0.75, 95% CI 0.67 to 0.83; 4 studies, 4839 participants; very low-certainty evidence). Data on patient-reported outcome measures came from single studies; it was not possible to meta-analyse the data.

Comparison 3: oncoplastic breast-conserving surgery (O-BCS) versus mastectomy with reconstruction

O-BCS may make little or no difference to local recurrence-free survival (HR 1.37, 95% CI 0.72 to 2.62; 1 study, 3785 participants; very low-certainty evidence) or disease-free survival (HR 0.45, 95% CI 0.09 to 2.22; 1 study, 317 participants; very low-certainty evidence) when compared to mastectomy with reconstruction, but the evidence is very uncertain. O-BCS may reduce the complication rate compared to mastectomy with reconstruction (RR 0.49, 95% CI 0.45 to 0.54; 5 studies, 4973 participants; very low-certainty evidence) but the evidence is very uncertain due to high risk of bias from confounding and inconsistency of results. The evidence is very uncertain for patient-reported outcome measures and cosmetic evaluation.

Health topics: