Some asthma sufferers rely on oral corticosteroids to control their disease. Corticosteroids help reduce the inflammation of the airways associated with asthma. Long-term use of these drugs has serious side effects, so other ways to reduce the need for corticosteroids are sometimes tried. Dapsone does have anti-inflammatory properties, and may have an effect on asthma symptoms and steroid doses taken. However, this review found that there was no evidence for or against the use of dapsone in the treatment of corticosteroid-dependent asthmatic patients. More research is needed.
閱讀完整摘要
Oral corticosteroids are used as a treatment for asthma, however they are often associated with serious side effects. Dapsone is a sulfone with anti-inflammatory properties, therefore it may have a beneficial effect in the treatment of asthma and act as a corticosteroid-sparing agent.
目的
The objective of this review is to assess the safety and efficacy of adding dapsone to oral corticosteroids in adults with stable asthma who are dependent on oral corticosteroids with the intention of eventually minimizing or eliminating the use of these steroids.
搜尋策略
We searched the Cochrane Airways Group Specialised Register and reference lists of potential articles. Date of last search: February 2011
選擇標準
Randomised controlled trials investigating the addition of dapsone compared to placebo in stable corticosteroid dependent asthmatics.
資料收集與分析
No trials were found that met the selection criteria.
主要結果
No meta-analyses could be performed.
作者結論
No randomised controlled trials have been published, so there is no reliable evidence to show whether dapsone is beneficial or otherwise in the management of steroid-dependent asthmatic patients. There is a need for well designed randomised controlled trials to be performed. These must be carried out double-blind, since oral corticosteroid reduction requires a judgement on the part of the physician, who may be open to bias if the treatment allocation is known.
