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Antibiotics for treating osteomyelitis in people with sickle cell diseaseMartí-Carvajal AJ, Agreda-Pérez LH, Cortés-Jofré M
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SummaryAntibiotics for treating osteomyelitis in people with sickle cell diseaseSickle cell disease affects millions of people throughout the world. Osteomyelitis, a bone infection, is one of the major complications. Antibiotics are given to treat it, but there is no worldwide standard treatment. We searched for randomised controlled trials which compared antibiotics (alone or in combination) with other antibiotics. We wanted to know if the different antibiotic treatments were effective, if they were safe, and which doses worked best for osteomyelitis in people with sickle cell disease. We did not find any trials to include in this review. We conclude that a randomised controlled trial should attempt to answer these questions.
This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2009 Issue 4, Copyright © 2009 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
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April 15. 2009 AbstractBackgroundOsteomyelitis (both acute and chronic) is one of the most common infectious complications in people with sickle cell disease. There is no standardized approach to antibiotic therapy and treatment is likely to vary from country to country. Thus, there is a need to identify the efficacy and safety of different antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis. ObjectivesTo determine whether an empirical antibiotic treatment approach (monotherapy or combination therapy) is effective and safe as compared to pathogen-directed antibiotic treatment and whether this effectiveness and safety is dependent on different treatment regimens, age or setting. Search strategyWe searched The Group's Haemoglobinopathies Trials Register, which comprises references identified from comprehensive electronic database searches and handsearching of relevant journals and abstract books of conference proceedings. We also searched the LILACS database (1982 to 14 January 2009) and www.clinicaltrials.gov (June 2008). Date of most recent search of the Haemoglobinopathies Trials Register: 14 November 2008. Selection criteriaWe searched for published or unpublished randomised and quasi-randomised controlled trials. Data collection and analysisEach author intended to independently extract data and assess trial quality by standard Cochrane Collaboration methodologies, but no eligible randomised controlled trials were identified. Main resultsWe were unable to find any randomised or quasi-randomised controlled trials on antibiotic treatment approaches for osteomyelitis in people with sickle cell disease. Authors' conclusionsWe were unable to identify any relevant trials on the efficacy and safety of the antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis. Randomised controlled trials are needed to establish the optimum antibiotic treatment for this condition. |