Infusion techniques for peripheral arterial thrombolysis

Background

Thrombolytic therapy is a useful tool in the management of acute peripheral arterial ischaemia. Fibrinolytic drugs are used to disperse blood clot to clear arterial occlusion. A variety of techniques are used to deliver these agents.

Objectives

To determine the optimal technique for infusion of fibrinolytic drugs in peripheral arterial ischaemia.

Search strategy

The Cochrane Peripheral Vascular Diseases Group searched for randomised controlled trials (RCTs) in their Specialised Register (February 6, 2006) and CENTRAL in The Cochrane Library (Issue 1, 2006). We searched Vascular Surgical and Radiological Societies' meetings proceedings. Reference lists of identified studies were also searched for relevant trials. Major pharmaceutical firms and trialists were asked about unpublished trials.

Selection criteria

Two authors independently selected RCTs comparing infusion techniques of fibrinolytic agents in the treatment of acute peripheral arterial ischaemia. Trials with poor quality methodology were excluded.

Data collection and analysis

We included the following data: limb salvage, amputation, death, vessel patency, time to achieve thrombolysis, and reduction in the need for surgical intervention. We compared complication rates for major haemorrhage, cerebrovascular accident and distal embolization.

Main results

Intra-arterial delivery of thrombolytic agents appeared to be more effective than intravenous administration. Thrombolysis was more effective when the angiographic catheter was placed within the thrombus. Although 'high dose' and 'forced infusion' techniques achieved vessel patency in less time than 'low dose infusion', there were more bleeding complications, and no increase in patency rates or improvement in limb salvage at 30 days.

Authors' conclusions

Implications for practice

Thrombolysis should be reserved for patients with limb threatening ischaemia, due to the high risk of haemorrhage or death.
Greater benefit is seen when the thrombolytic agent is delivered into the thrombus. Systemic intravenous thrombolysis is less effective than intra-arterial thrombolysis and is associated with an increase in bleeding complications.
'High dose' and 'forced infusion' techniques, or adjunctive agents such as platelet glycoprotein IIb/IIIa inhibitors may speed up thrombolysis, but these are not accompanied by lower amputation rates or a decreased need for adjunctive endovascular or surgical procedures.
'Low dose continuous infusion', following initial lacing of the thrombus with a high dose of the thrombolytic agent, is the least labour intensive technique.

Implications for research

Only large multicentre trials with carefully controlled inclusion criteria will be sufficiently powerful to demonstrate genuine benefit for a particular thrombolytic regime.