Our primary objective is to determine the diagnostic accuracy of the APOE-ε4 allele in detecting AD dementia and other types of dementia in people with MCI in a secondary care setting.
Our secondary objective is to investigate the following potential sources of heterogeneity of test accuracy, where reported:
- characteristics of participants, namely, baseline MMSE score, age, and gender;
- APOE-ε4 background prevalence;
- MCI definition;
- length of follow-up; and
- reference standards.
This is a protocol.