Blood pressure lowering effect of diuretics as second line therapy for primary hypertension in crossover trials

Primary objective
  • To quantify the additional reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) of diuretics as second-line therapy in patients with primary hypertension based on cross-over trials.
Secondary objectives
  • To quantify the effects of a second-line diuretic on heart rate (HR).
  • To quantify the effects of a second-line diuretic on withdrawals due to adverse effects (WDAE).

This is a protocol.

Share/Save