Symptoms, ultrasound imaging and biochemical markers alone or in combination for the diagnosis of ovarian cancer in women with symptoms suspicious of ovarian cancer

To establish the accuracy of symptoms, ultrasound and biomarkers alone or in combination for the diagnosis of ovarian cancer in pre- and postmenopausal women.

To compare the accuracy of different tests or test combinations.

We will investigate the following sources of heterogeneity:

Population
  • Clinical setting (generalist/primary care/community/family practice) versus specialist setting (cancer unit/cancer centre/gynaecological oncology)
  • Menopausal status
Index tests
  • Test positivity threshold
  • Experience of the ultrasound test operator (general sonographers versus specialist interest)
Target condition
  • Histological subtype
Study quality
  • Case-control versus other study designs
  • Study quality: for study participants not receiving surgery initially following a negative index test result: 12 months follow-up versus less than 12 months follow-up

This is a protocol.

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