To determine the diagnostic accuracy of pulse oximetry as a screening method for the detection of critical congenital heart defects in asymptomatic newborn infants. Diagnostic accuracy is described by the proportion of asymptomatic newborn infants with CCHD detected by a positive pulse oximetry result (sensitivity), and the proportion of asymptomatic newborn infants with a negative pulse oximetry result who did not have CCHD (specificity).
To assess potential sources of heterogeneity including:
- study design: retrospective vs prospective design, consecutive vs non consecutive series
- timing of testing: < 24 hours vs ≥ 24 hours after birth
- site of testing: right hand and foot (pre-ductal and post-ductal) vs foot only (post-ductal)
- oxygen saturation: functional vs fractional
- characteristics of the population: antenatal screening.
This is a protocol.