Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn


To determine whether the use of prophylactic calcium reduces the risk of hypocalcaemia-related morbidities and death among newborn infants receiving EBT.


We will perform subgroup analysis to address:

  1. preterm (< 37 weeks gestation) versus term (≥ 37 weeks gestation);
  2. the type of anticoagulant in the blood transfused (comparison will be made between citrate and heparin);
  3. the volume of blood used (comparison will be made between single-volume and double-volume EBT);
  4. timing of administration of calcium (comparison will be made between administration during EBT or administration immediately after EBT).

This is a protocol.