Blood pressure targets for hypertension in patients with chronic renal disease

Primary objective

To determine if there is a reduction in total mortality and morbidity associated with treatment of blood pressure to "lower targets" as compared with "standard targets" in the management of patients with chronic renal disease and elevated arterial blood pressure.  "Lower targets" are defined as blood pressure targets less than or equal to 130/80 mmHg.  "Standard targets" are defined as blood pressure targets less than or equal to 140-160 mmHg systolic and/or blood pressure targets less than or equal to 90-100 mmHg diastolic. 

Secondary objectives
  1. To determine if there is a change in mean achieved systolic and diastolic blood pressure associated with "lower targets" as compared with "standard targets" in patients with chronic renal disease with elevated blood pressure.  
  2. To determine if there is a change in withdrawals due to adverse events with "lower targets" as compared with "standard targets", in patients with chronic renal disease with elevated blood pressure.
  3. To determine if there is a change in mean decline in glomerular filtration rate with "lower targets" as compared with "standard targets", in patients with chronic renal disease with elevated blood pressure.  

This is a protocol.

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