High versus standard protein content of human milk fortifier for promoting growth and neurological development in preterm infants

The primary objective of this review is to determine the effects of high protein content (=> 1 g per 100 ml of human milk) vs. standard protein content (< 1 g per 100 ml of human milk) of human milk fortifier on growth and neurological development in preterm infants.

A series of subgroup analyses will be undertaken to assess the effect of protein dose on primary outcomes as follows:
1. in more vulnerable, less mature infants (defined as < 1250 g or < 28 weeks gestation)
2. by compliance (when intake of fortified human milk is > 80% of intake).
3. by use of hydrolysed protein.

This is a protocol.

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