Interventions for previously untreated AIDS-associated Hodgkin´s lymphoma in adults

There is a lack of evidence from randomised controlled trials for the efficacy and safety of different interventions for treating AIDS-associated Hodgkin's disease, regarding both overall survival and disease-free survival in treatment-naive adults with AIDS. Lymphoma is a cancer of the lymphatic system. Lymphomas are classified into two general types: Hodgkin's disease and non-Hodgkin's lymphomas. Hodgkin's disease is the most common non-AIDS-defining malignancy in HIV-infected patients. Randomised controlled trials for the efficacy and safety of different interventions for treating AIDS-associated Hodgkin's disease on overall survival and disease-free survival in treatment-naive adults with AIDS could not be found.

Authors' conclusions: 

Randomised controlled trials are needed to establish the efficacy and safety of interventions for treating AIDS-associated HD in treatment-naive adults with AIDS.

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Background: 

Hodgkin's disease (HD) is the most common non-AIDS-defining malignancy in HIV-infected patients. Its unusually aggressive tumour behaviour includes a higher frequency of unfavourable histologic subtypes, high-stage and extranodal involvement by the time of presentation (anal canal, stomach), and poor therapeutic outcome, in comparison with HD outside the HIV setting. The optimal therapeutic strategy is still controversial, and median overall survival is short, ranging from 12 to 18 months. Thus, there is a need to identify the efficacy and safety of different interventions for AIDS-associated HD on overall survival and disease-free survival in treatment-naive adults with AIDS.

Objectives: 

To assess the effects of different interventions for treating AIDS-associated Hodgkin's disease including chemotherapy, bone marrow transplantation (BMT), and gene therapy on overall survival and disease-free survival in treatment-naive adults with AIDS.

Search strategy: 

We searched The Cochrane HIV/AIDS Group Trials Register (September 2006), which comprises references identified from comprehensive electronic database searches and handsearching of relevant journals and abstract books of conference proceedings. We also searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (Issue 3, 2006), MEDLINE (1966 to September 2006), EMBASE (1974 to September 2006) LILACS (1982 to September 2006), ISI Web of Knowledge (1993 to September 2006), and AIDSearch (1980 to December 2006).

Date of most recent search: December 2006.

Selection criteria: 

We searched for published or unpublished randomised controlled trials.

Data collection and analysis: 

We intended to summarise data by standard Cochrane Collaboration methodologies, but no eligible randomised controlled trials were identified.

Main results: 

We were unable to find any randomised controlled trials of interventions for treating AIDS-associated HD in treatment-naive adults with AIDS.

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