The objective of this review is to determine the effectiveness and toxicity of calcium channel blockers for the treatment of RP in scleroderma.
The specific hypotheses to be tested are that these therapies can:
1) reduce the frequency of attacks
2) reduce the severity of attacks
3) increase digital skin temperature
4) improve the patient and physician's global assessment of the impact of RP
5) prevent new ulcers/gangrene/heal existing ulcers
This is a protocol.