In this PhD, Individual Participant Data will be collected from eligible RCTs of add-on treatment in patients with refractory epilepsy. Statistical issues for the analysis of these trials will be explored and a network meta-analysis undertaken using the most efficient and statistically reliable methods. It is anticipated that the characteristics of trials and their participants will have changed over time due to the changing global nature of epilepsy research, the widening population of available AEDs, and changes in the classification and management of epilepsy. Patients within, and across, trials will also differ in the adjunctive AEDs taken alongside the experimental add-on AED or placebo. Such differences are likely to impact upon the underlying assumptions made in a network meta-analysis and the value of having IPD to thoroughly explore such issues will be fully exploited. The research would be completed with support from the Cochrane Epilepsy Group.
- You should have, or expect to hold an MSc in Statistics or relevant discipline.
- For European/UK Students only.
- The English Language Requirement for EU Students is an IELTS score of 6.5 with no band score lower than 5.5.
- The studentship would be funded for three years at Home/EU rate, with a RCUK Stipend of 14,553 per annum.
The research would be completed with support from the Cochrane Epilepsy Group. Cochrane is a global, independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesizing research findings to produce the best available evidence on what can work, what might harm and where more research is needed. Our work is recognised as the international gold standard for high quality, trusted information.