Calcitonin testing for detection of medullary thyroid cancer in patients with thyroid nodules

The objective of this review is to determine the diagnostic accuracy of calcitonin testing in the detection of MTC in patients with thyroid nodules.

We will investigate whether calcitonin screening should be performed in all patients with thyroid nodules or whether screening should be limited to subgroups of patients. Firstly we will test differences in cut-off values, assay types and different verification methods as these are likely to have the most influence on heterogeneity. Depending on the number of included studies, we will perform further subgroup analyses.

  • Age.
  • Gender.
  • Nodules detected by palpation or ultrasound.
  • Nodule size.
  • Number of nodules.
  • Sonographic morphology of thyroid nodules.
  • FNA procedures performed through ultrasound guidance versus palpation.
  • Basal versus stimulated calcitonin testing.

This is a protocol.