Cochrane

Review question We reviewed the evidence about the effect of high-dose chemotherapy (medicines to kill the cancer) followed by autologous hematopoietic stem cell transplantation compared to standard-dose chemotherapy on overall survival (time from cancer diagnosis, or treatment, to death from any cause) in people with nonrhabdomyosarcoma soft tissue ...

Sarcomas are tumours that arise from bone and soft tissues. They can occur in all ages. As a result of the introduction of polychemotherapy, the survival of children and young adults with different types of sarcoma has improved dramatically. Alkylating agents, such as cyclophosphamide and ifosfamide, have played a major role in this improvement. However, ...

Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Fifteen percent of  rhabdomyosarcoma patients already have metastases when the disease is discovered. With conventional dose chemotherapy survival generally is poor, therefore using 'high-dose' chemotherapy has been studied to see if this can improve survival. This type of chemotherapy ...

Doxorubicin is commonly used as palliative chemotherapy for patients with advanced or metastatic soft tissue sarcoma (cancer of muscle/tendon/fat/blood vessel). This review was conducted to find out if combining doxorubicin with other drugs is more effective than doxorubicin alone. Eight studies were considered together, which showed if combination ...