Cochrane

What is the aim of this review? The aim of this Cochrane Review was to find out if using topical sunscreen and physical barrier methods (such as sun-protective clothing, hats, sunglasses, and the active search for shade when outdoors) compared with no specific precautionary activity prevented the development of basal cell carcinoma (BCC) and cutaneous ...

Background Melanoma arises from the uncontrollable growth of cells in the skin that produce the pigment melanin; it is the leading cause of skin cancer-associated mortality. In invasive melanoma, the tumour has infiltrated into the dermis (a deep layer in the skin). For invasive skin cancer that is localised, the treatment of choice is complete surgical ...

Background Melanoma in situ (MIS) is the earliest stage of malignant melanoma. Over the past two decades, the incidence of MIS has increased. Lentigo maligna (LM) is a subtype of pre-invasive melanoma associated with chronic exposure to ultraviolet radiation, primarily affecting the head and neck. It accounts for 79% to 83% of all MIS tumours. Delayed ...

Review questionTo compare the effectiveness, cost, complications and acceptability of two different surgical techniques for treating basal cell carcinoma (BCC) around the eyes. BackgroundBCC is the commonest skin cancer and the most common cancer in people of white origin. It is usually seen on the sun exposed parts of the body like the face, neck, ...

Kaposi’s sarcoma was the first tumor to be described in association with HIV infection and is an AIDS-defining condition. It is also known as Kaposi's sarcoma-associated herpes virus (KSHV) as Herpes virus 8 (HHV8) is recognized as an essential and necessary factor in the pathogenesis of KS. Nonetheless, not all HHV-8-infected individuals will develop ...

Bowen's disease is the clinical term for a particular precancerous skin lesion. These lesions rarely cause patients any symptoms, but appear as well-defined scaly patches on sun-exposed skin, commonly in those over 60 years. They occur more in women and most frequently involve the lower legs of those affected in the UK. It is not known why, but the ...

Cutaneous melanoma is one of the deadliest types of skin cancer, and its incidence is rising in all Western countries. Furthermore, melanoma is one of the solid tumours most resistant to treatment with chemotherapy, which means that the outlook for people whose cancer has spread through their body (distant metastatic disease) is dismal, with only 10% ...

Actinic keratoses are a skin disease caused by long-term sun exposure. Damaged skin shows small, red, rough, scaly, flat spots called actinic keratoses or lesions, which feel like patches of dry skin. Symptoms such as bleeding and pain can be associated with actinic keratoses. Moreover, actinic keratoses have the potential to develop into skin cancer ...

Squamous cell carcinoma (SCC) of the skin is the second most common skin cancer in people of white origin, most frequently occurring on sun-exposed areas of the body. People with fair skin and those with certain genetic conditions or an impaired immune system are at greater risk of developing SCC of the skin. Clinically, SCC often appears as a persistent ...

Whilst melanoma accounts for only 5% of skin cancers, it is important because it is the cause of 75% of all skin cancer deaths. For primary cutaneous melanoma, standard treatment is complete surgical removal of the melanoma with a safety margin some distance from the visible edges of the primary tumour. The purpose of the safety margin is to remove ...