Cochrane

What is Crohn's disease? Crohn’s disease is a life-long (chronic), inflammatory disease of the gastrointestinal tract characterized by abdominal pain (cramping), rectal bleeding, diarrhoea, weight loss, and tiredness. The disease has a changing course with periods of symptoms (called 'active' disease or relapse) and periods without symptoms (called ...

What is lymphocytic colitis? Lymphocytic colitis is a type of microscopic colitis, a condition characterized by chronic non-bloody watery diarrhea. People with lymphocytic colitis have a normal appearing bowel when assessed by an endoscope (a camera used to look at the bowel) or an X-ray; but have microscopic (histological) inflammation of the bowel ...

Protocol: Primary objectives 1. To assess the efficacy and safety of antidepressants for managing anxiety and depression in IBD 2. To assess the efficacy and safety of antidepressants for managing quality of life in IBD Secondary objectives 1. To assess the efficacy and safety of antidepressants for managing disease activity in IBD

Protocol: The primary objective of this study is to systematically review the effect of surgical interventions for IBD on female fertility and to investigate whether these procedures result in a post-operative reduction in fertility. Secondly, we will evaluate the impact of surgical interventions on the use of assisted reproductive technologies ...

Background Cancer of the colon or rectum that has spread to other organs (metastatic colorectal cancer) is a commonly occurring disease that usually cannot be surgically removed. The main treatment is chemotherapy, targeted therapy (such as EGFR inhibitors, the subject of this review), or both. The epidermal growth factor receptor (EGFR) is a protein ...

Review question What are the benefits and harms of various gases for insufflation (inflation with gas) of the abdominal (tummy) cavity to allow easier access to organs during laparoscopic (key-hole) abdominal surgery? Background Laparoscopic (key hole) surgery is now widely performed to treat various abdominal diseases. An ideal gas for insufflation ...

Background Cirrhosis is a chronic disorder of the liver where scar tissue replaces the normal liver. People with cirrhosis can develop a kidney disease known as hepatorenal syndrome. The disease may develop when the blood flow to the kidneys becomes insufficient. Increasing the blood flow to the kidneys may therefore benefit people with hepatorenal ...

Protocol: To evaluate the beneficial and harmful effects of endoscopic therapy and beta-blockers used as a combination therapy versus monotherapy with either endoscopic therapy or beta-blockers for secondary prevention in people with cirrhosis and oesophageal varices.

Protocol: Primary Effectiveness of antacids, sucralfate and bismuth salts in reducing overall functional dyspepsia symptoms in dyspeptic people. Secondary Quality of life Individual dyspepsia symptom change Adverse events and complications

Background Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Numerous previous interventions have been used for hepatitis C, but none of these interventions have proven effective on patient-centred outcomes. DAAs are relatively new but expensive interventions for hepatitis C, and ...