Cochrane

What is Crohn's disease? Crohn’s disease is a life-long (chronic), inflammatory disease of the gastrointestinal tract characterized by abdominal pain (cramping), rectal bleeding, diarrhoea, weight loss, and tiredness. The disease has a changing course with periods of symptoms (called 'active' disease or relapse) and periods without symptoms (called ...

Review question: Does head midline position reduce the risk of intraventricular hemorrhage (i.e., bleeding in the brain) and mortality in very preterm infants? Background: Intraventricular hemorrhage (i.e., bleeding in the brain) occurs in 25% of very low birth weight infants and may be caused by multiple factors. Head position may affect how the ...

Review question: How does saline irrigation or saline irrigation with prior hyaluronidase compare with no intervention or normal wound care for improving tissue healing in neonates with extravasation injury? Background: Preterm and sick term infants requiring intravenous fluids and medications are vulnerable to tissue injury secondary to extravasation, ...

Bottom line There is no evidence from randomised controlled trials to support or contradict the suggestion that opioids in any dose will reduce cancer-related pain in children or adolescents. Background Childhood cancer is one of the leading causes of disease and death for children and adolescents in the world today. Its associated pain is a ...

Review question This review aimed to assess whether felbamate has an impact on people with refractory partial-onset epilepsy when used with other antiepileptic drugs. Background Up to 30% people with epilepsy still suffer epileptic seizures despite the use of multiple treatments. Felbamate is a second-generation antiepileptic drug. However, it is ...

Protocol: To compare the effectiveness and safety of conventional and complex shunt devices for CSF diversion in people with hydrocephalus.

Review question Does the use of prolonged (or sustained, > 1 second duration) lung inflation rather than standard inflations (≤ 1 second) improve survival and other important outcomes among newly born babies receiving resuscitation at birth? Background At birth, the lungs are filled with fluid, which must be replaced by air for babies to breathe ...

Protocol: To evaluate the comparative effectiveness and safety of various materials used in frontalis sling surgery for congenital ptosis.

Review question We reviewed the evidence about whether antiseptics are safe and effective for treating burn wounds. Background Burn wounds cause many injuries and deaths worldwide. People with burn wounds are especially vulnerable to infections. Antiseptics prevent the growth of micro-organisms such as bacteria. They can be applied to burn wounds ...

Protocol: To assess the effects of silver diamine fluoride in arresting and preventing caries in deciduous and permanent teeth (coronal and root caries) compared to any other intervention including placebo or no treatment.