Cochrane

What is Crohn's disease? Crohn’s disease is a life-long (chronic), inflammatory disease of the gastrointestinal tract characterized by abdominal pain (cramping), rectal bleeding, diarrhoea, weight loss, and tiredness. The disease has a changing course with periods of symptoms (called 'active' disease or relapse) and periods without symptoms (called ...

Protocol: To determine whether antibiotic therapy is safe and effective for induction or maintenance of remission in CD.

What is lymphocytic colitis? Lymphocytic colitis is a type of microscopic colitis, a condition characterized by chronic non-bloody watery diarrhea. People with lymphocytic colitis have a normal appearing bowel when assessed by an endoscope (a camera used to look at the bowel) or an X-ray; but have microscopic (histological) inflammation of the bowel ...

Protocol: Primary objectives 1. To assess the efficacy and safety of antidepressants for managing anxiety and depression in IBD 2. To assess the efficacy and safety of antidepressants for managing quality of life in IBD Secondary objectives 1. To assess the efficacy and safety of antidepressants for managing disease activity in IBD

Protocol: The primary objective of this study is to systematically review the effect of surgical interventions for IBD on female fertility and to investigate whether these procedures result in a post-operative reduction in fertility. Secondly, we will evaluate the impact of surgical interventions on the use of assisted reproductive technologies ...

Protocol: The objective of this systematic review is to determine the efficacy and safety of biologics for inducing mucosal healing in CD.

Protocol: The objectives of this systematic review are to determine the efficacy and safety of biologics for maintaining mucosal healing in CD.

What is ulcerative colitis? Ulcerative colitis is a life-long (chronic) inflammatory bowel disease that causes inflammation and ulceration (sores) in the large intestine (colon). Patients with ulcerative colitis often experience diarrhoea, bloody stools, weight loss and abdominal pain. When patients experience symptoms, the disease is considered ...

Protocol: The primary objective is to assess the efficacy and safety of infliximab for induction of remission in patients with active CD.

Protocol: The primary aim of this systematic review is to determine the efficacy and safety of infliximab for maintaining remission in patients with CD.