Cochrane

Review question This review aimed to assess whether felbamate has an impact on people with refractory partial-onset epilepsy when used with other antiepileptic drugs. Background Up to 30% people with epilepsy still suffer epileptic seizures despite the use of multiple treatments. Felbamate is a second-generation antiepileptic drug. However, it is ...

Background Despite many antiepileptic drugs being available, about 30% of epilepsy patients are not seizure-free. Electrical stimulation through implanted electrodes in contact with the brain (i.e. intracranial electrical stimulation, referring to 'deep brain stimulation' and 'cortical brain stimulation') has been proposed as an alternative treatment ...

Protocol: To assess the effects of medications for daytime sleepiness and related symptoms in individuals with idiopathic hypersomnia, and in particular whether medications may: reduce subjective measures of sleepiness; reduce objective measures of sleepiness; reduce symptoms of cognitive dysfunction; improve quality of life; and be associated ...

Background Epilepsy is a disorder where recurrent seizures are caused by abnormal electrical discharges in the brain. People with epilepsy may present with various types of immunological abnormalities. Most seizures can be controlled by antiepileptic drugs, but sometimes seizures develop which are resistant to these drugs. People may require other ...

Background Epilepsy is a common neurological disorder in which abnormal electrical discharges from the brain cause recurrent seizures. We studied two types of epileptic seizures in this review: partial seizures that start in one area of the brain, and generalised onset tonic-clonic seizures that start in both cerebral hemispheres simultaneously. For ...

Protocol: To assess the effects of gabapentin monotherapy for people with epileptic partial seizures with and without secondary generalisation.

Background Severe myoclonic epilepsy in infants (SMEI), also known as Dravet syndrome, is a rare, drug-resistant form of epilepsy, for which stiripentol (STP) has been recently licensed for treatment when given in combination with other antiepileptic drugs. In this review, we evaluated the efficacy and tolerability of STP and other antiepileptic drugs ...

Epilepsy Group Victoria Walter Title Wednesday, May 3, 2017 ...

Background Juvenile myoclonic epilepsy (JME) is characterized by involuntary (uncontrolled) twitching of muscles in shoulders and arms after awakening, often starting in childhood. Study characteristics We searched scientific databases for clinical trials comparing the antiepileptic drug, topiramate, with placebo (a pretend treatment) or another ...

Epilepsy Group Francesco Brigo Title Thursday, March 2, 2017 ...