Cochrane

What is the issue? Calcineurin inhibitors (CNI, cyclosporin and tacrolimus) are an important part of treatment to suppress the immune system to prevent rejection of transplanted kidneys. However, CNI can cause high blood pressure and kidney scarring which contribute to worsening of risk factors for heart attack, stroke, and loss of the transplanted ...

What is the issue? Kidney transplantation is the treatment of choice for most patients with end-stage kidney disease. Strategies to increase donor organ availability and to prolong the transplanted kidney's survival have become priorities in kidney transplantation. About 10% to 35% of all kidney transplant recipients will experience one episode of ...

What is Crohn's disease? Crohn’s disease is a life-long (chronic), inflammatory disease of the gastrointestinal tract characterized by abdominal pain (cramping), rectal bleeding, diarrhoea, weight loss, and tiredness. The disease has a changing course with periods of symptoms (called 'active' disease or relapse) and periods without symptoms (called ...

Protocol: To determine whether antibiotic therapy is safe and effective for induction or maintenance of remission in CD.

Protocol: To determine whether administration of prebiotics reduces the incidence of hyperbilirubinaemia among term and preterm infants compared with enteral supplementation of milk with distilled water or no supplementation.

Protocol: To review the clinical effectiveness and safety of haloperidol compared with risperidone for people with schizophrenia.

Review question We wanted to find out if one type of artificial breathing device used in adults during anaesthesia is more effective and safer than another. Background Patients anaesthetized for surgical procedures often need to be put on artificial breathing machines (ventilators) to help their breathing. This involves putting into the patient's ...

Review question: Does head midline position reduce the risk of intraventricular hemorrhage (i.e., bleeding in the brain) and mortality in very preterm infants? Background: Intraventricular hemorrhage (i.e., bleeding in the brain) occurs in 25% of very low birth weight infants and may be caused by multiple factors. Head position may affect how the ...

The purpose of consumer involvement in Cochrane Cochrane is a global independent network of researchers, professionals, and people interested in health, including healthcare consumers. Cochrane's healthcare consumers are made up from a wide range of ...

Review question What are the effects of occupational therapy for adults with stroke on activities of daily living? Background Different parts of the brain carry out different functions: seeing, sensation, balance, movement, understanding language, behaviour, problem solving, and emotion. A stroke occurs when the blood supply to part of the brain is ...