Cochrane

Background To stop further damage and restore function of primary molar teeth that are decayed or malformed, a dentist will usually use a filling (a soft material that is placed in the cavity and hardened) to restore the tooth to its original shape. Alternatively the dentist may place a crown over the tooth to cover it. This usually requires an injection ...

Review question We reviewed the evidence on new localization techniques against the gold standard (wire-guided) for the surgical removal of non-palpable breast lumps. Background Breast cancer screening has brought a shift towards earlier detection of non-palpable breast lumps (i.e. lumps that cannot be felt by palpation by a doctor). Surgical ...

Protocol: To establish the effects of grommet insertion (with or without concurrent adenoidectomy) for children with rAOM.

When the immune system of a patient is unable to fight infections (for example because of prolonged corticosteroid therapy, immunosuppressive drugs, haematological malignancies or HIV/AIDS) invasive or systemic aspergillosis can be a life-threatening mycotic (fungal) infection. Establishing a diagnosis of invasive aspergillosis at an early stage of ...

Background: Drinking is influenced by youth perceptions of how their peers drink. These perceptions are often incorrect, overestimating peer drinking norms. If inaccurate perceptions can be corrected, with social norms information or feedback, young people may drink less. Search date: To July 2015. Study characteristics: 70 studies were included ...

Background Migraine and cluster headaches are severe and disabling. Hyperbaric oxygen therapy (HBOT, that is the breathing of pure oxygen at pressures greater than one atmosphere in a pressurised chamber) and normal pressure oxygen therapy (NBOT) can be delivered via a mask at home or in a clinic. These treatments may help to end acute attacks and ...

Protocol: To compare the effectiveness and safety of weekly paclitaxel with that of three-weekly paclitaxel, in combination with carboplatin, as first-line chemotherapy treatment for ovarian cancer.

Review question We reviewed the evidence about whether antifibrinolytic medicine (drugs that promote blood clotting) such as tranexamic acid or epsilon aminocaproic acid, can prevent oral bleeding in people with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions. Background Haemophilia and Von Willebrand disease ...

Protocol: The aim of this review is to assess the efficacy and safety of interventions for fatigue in IBD.

Background Epilepsy is spectrum of disorders in which a person may have seizures (fits) that are unpredictable in frequency. Most seizures are well controlled with medicines and other types of treatments but epilepsy can cause problems in social, school and work situations, and make independent living difficult. People with seizures tend to have physical ...