Cochrane

Background Medulloblastoma is one of the most common malignant brain tumours in children. Chemotherapy is used to improve survival and diminish potential radiotherapy-induced side effects. The reduction of radiotherapy-induced side effects is achieved in very young children by not treating them with radiotherapy and in older children by diminishing ...

Background Anaemia is common, affecting about a quarter of the world's population. Anaemia can be defined as a reduction in the number of circulating red cells or in the quantity of haemoglobin (both of which carry oxygen) in the blood. An estimated 50% of anaemic people have anaemia due to iron deficiency. We wanted to assess the safety and usefulness ...

In many countries a large investment is being made in technology to computerize patient medical records. One potential of electronic health records (EHR) is that they could be used to remind doctors and other clinic staff to record tobacco use, to give brief advice to quit, to prescribe medications and to refer to stop smoking counselling. They could ...

Protocol: To evaluate whether and to what extent grapefruit juice interacts with individual calcium channel blockers in healthy adults.

Protocol: To assess the clinical benefits and harms of acetyl-L-carnitine for treating patients with hepatic encephalopathy.

Review question Is uterine artery embolization a safe and effective alternative treatment in women with symptomatic fibroids? Background Uterine fibroids (benign tumours) can cause varied symptoms such as heavy bleeding, pain and reduced likelihood of pregnancy. Surgery (hysterectomy or myomectomy) has traditionally been the main treatment option ...

Protocol: To assess the effects of adhesive bonded restorations in reducing dentine hypersensitivity in adults compared with any non-adhesive interventions or no treatment.

Review question We examined the evidence regarding the effect of herbal medicine on pain in people with non-specific low-back pain (LBP). Background Back pain is common and up to 35% of the population can be affected in a given month. Non-specific LBP is defined as pain between the lowest rib and the bottom of the buttocks that is not caused by serious, ...

Review question We wanted to know if honey can reduce cough symptoms caused by bacteria and viruses in children. Background Cough is a cause for concern for parents and a major cause of outpatient visits in most clinics for both children and adults. Cough can affect quality of life, cause anxiety and affect sleep for parents and children. An ...

With burn injuries involving a large total body surface area, damage and breakdown of tissues can result in a condition similar to that seen with severe malnourishment. In addition, destruction of the effective skin barrier leads to body temperature dysregulation and increased susceptibility to infection and fluid loss. Previous studies have investigated ...